Hidden Infarcts Detected by a High b-Value Diffusion-Weighted Imaging: A Parameter-Optimized Study

2019 ◽  
Vol 9 (2) ◽  
pp. 308-313
Author(s):  
Xiubao Song ◽  
Xi Xu ◽  
Yufeng Ye ◽  
Jianye Liang ◽  
Mengjie Ma ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Diffusion Weighted Imaging ◽  
Contrast Ratio ◽  
B Value ◽  
Acute Cerebral Infarction ◽  
Matrix Size ◽  
Diffusion Weighted ◽  
The Matrix ◽  
Adc Values ◽  
Noise Ratio

Objective: Small infarcts are easily missed on conventional sequences or a standard b-value diffusion-weighted imaging (DWI). This study aims to investigate the signal characteristics of DWI with different b-values and matrixes in acute cerebral infarction, and evaluate the feasibility of high b-values used in DWI. Methods: Twenty-nine cases of clinically diagnosed acute cerebral infarction were included prospectively in this study. The patients underwent MRI examinations, including routine T1WI, T2WI, T2 Flair, and different b-value DWIs (b = 1000, 1500, and 2000 s/mm2 with matrix 160 × 160. In addition, b = 1000 DWI was divided into two groups with different matrixes of 128 × 128 and 160 × 160. The differences of the signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), contrast ratio (CR), and apparent diffusion coefficient (ADC) values between the different b-values and matrixes DWI were compared. Results: Visually, b =1500 and b = 2000 DWI showed more scattering and micro-lesions than a standard DWI. The lesions shown in the high b-value DWI were more conspicuous and brighter. Quantitatively, with the increase in b-values, the SNR, CNR, and ADC values decreased gradually, but the CR increased gradually. With a reduction in the matrix size, the SNR and CNR improved (all the results were statistically significant with good inter-observer reliability). Conclusions: A high b-value for DWI is beneficial for the detection of micro- and hyperacute infarction, but the image quality declines. However, reducing the matrix size appropriately could make up for this deficiency.

Usefulness of high-b-value diffusion-weighted imaging in acute cerebral infarction

2006 ◽  
Vol 17 (5) ◽  
pp. 1212-1220 ◽  
Author(s):  
Keiko Toyoda ◽  
Satomi Kitai ◽  
Masahiro Ida ◽  
Sadao Suga ◽  
Yutaka Aoyagi ◽  
...  
Keyword(s):  
Cerebral Infarction ◽  
Diffusion Weighted Imaging ◽  
B Value ◽  
Acute Cerebral Infarction ◽  
High B Value ◽  
Diffusion Weighted

The utility of diffusion-weighted imaging and ADC values in the characterization of mumps orchitis and seminoma

2021 ◽  
pp. 028418512199198
Author(s):  
Renwei Liu ◽  
Jianhua Li ◽  
Yixiang Jiang ◽  
Zhiqing Wu ◽  
Jiayin Ji ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Testicular Tissue ◽  
B Value ◽  
Youden Index ◽  
Characteristic Analysis ◽  
Adc Value ◽  
High B Value ◽  
Diffusion Weighted ◽  
Hyperintense Signal ◽  
Adc Values

Background Diffusion-weighted imaging (DWI) can quantitatively reflect the diffusion characteristics of tissues, providing a theoretical basis for qualitative diagnosis and quantitative analysis of a disease. Purpose To characterize testicular lesions that present as a hypointense signal on magnetic resonance imaging (MRI) T2-weighted images using DWI. Material and Methods Study participants were divided into three groups. Group A were healthy controls (n = 35), group B included patients with mumps orchitis (n = 20), and group C included patients with seminoma (n = 15). DWI sequences used b-values of 0, 1000, and 2000 s/mm2. Apparent diffusion coefficient (ADC) values between 1000 and 2000 s/mm2 were calculated by MRI postprocessing software. The Kruskal–Wallis test and receiver operating characteristic analysis were performed to evaluate how well ADC values distinguished between mumps orchitis and seminoma. Results Normal testicular tissue showed a hyperintense signal on DWI and hypointensity on the ADC map: mean ADC value was 0.77 (0.69–0.85) ± 0.08 ×10−3 mm2/s. Mumps orchitis and seminoma showed slight hyperintensity on DWI: mean ADC values were 0.85 (0.71–0.99) ± 0.15 ×10−3 mm2/s and 0.43 (0.39–0.47) ± 0.04 × 10−3 mm2/s, respectively. There were statistically significant differences in mean ADC values between normal testicular tissue and seminoma and between mumps orchitis and seminoma. The cutoff ADC value for differentiating seminoma from mumps orchitis was 0.54 × 10−3 mm2/s. The sensitivity, specificity, and Youden Index for diagnosing seminoma were 99%, 31%, and 30%, respectively. Conclusion High b-value DWI has potential utility for differentiating mumps orchitis from seminoma in the clinical setting.

Study of Multi-b-Value Diffusion-Weighted Imaging at 3.0 T for Measuring Renal Function of Patients with Chronic Renal Failure

2014 ◽  
Vol 998-999 ◽  
pp. 320-324
Author(s):  
Jun Lai Xue ◽  
Meng Chao Zhang ◽  
Mao Hua Zhang ◽  
Dong Tong ◽  
Wu Qiang
Keyword(s):  
Renal Function ◽  
Diffusion Weighted Imaging ◽  
Impaired Renal Function ◽  
Filtration Rate ◽  
B Value ◽  
Renal Imaging ◽  
Diffusion Weighted ◽  
Apparent Diffusion ◽  
Adc Values ◽  
3.0 T

To investigate the relationship between apparent diffusion coefficient (ADC) values measured by diffusion-weighted imaging (DWI) on a 3.0T MR unit and glomerular filtration rate (GFR) determined by renal imaging using Nuclear Medicine 99 Tcm-DTPA. 3.0T MRI DWI and 99 Tcm-DTPA renal imaging were simultaneously performed in 30 patients with chronic renal failure. The b values set for DWI imaging were 0, 200, 400, 600, 800 and 1000 s/mm2 and the ADC values of renal cortex were measured. 60 kidneys from the patients were classified into three groups according to the measurements of GFR: mildly impaired renal function, moderately impaired renal function and severely impaired renal function. ADC values of the three groups were compared to determine whether there existed statistic difference and the correlation between ADC values and GFR was also measured. Statistical difference was found in ADC values of the three groups and a positive correlation was identified between ADC values and GFR (r = 0.623). Multi-b-value diffusion-weighted MR imaging at 3.0 T can be used to assess renal filtration function.Abbreviation used: DWI, diffusion-weighted imaging; ADC, apparent diffusion coefficient; GFR, glomerular filtration rate; NEX, number of excitation.

scholarly journals Quantitative evaluation of computed and voxelwise computed diffusion-weighted imaging in breast cancer

2019 ◽  
Vol 92 (1100) ◽  
pp. 20180978
Author(s):  
Qingyuan Cheng ◽  
Shuxin Ye ◽  
Chuqi Fu ◽  
Jiejie Zhou ◽  
Xiaxia He ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Diffusion Weighted Imaging ◽  
Signal To Noise Ratio ◽  
Contrast Ratio ◽  
B Value ◽  
B Values ◽  
Diffusion Weighted ◽  
Malignant Lesions ◽  
The Mean ◽  
Age Range

Objectives: To assess the value of computed diffusion-weighted imaging (cDWI) and voxelwise computed diffusion-weighted imaging (vcDWI) in breast cancer. Methods: This retrospective study involved 130 patients (age range, 25–70 years; mean age ± standard deviation, 48.6 ± 10.5 years) with 130 malignant lesions, who underwent MRI examinations, including a DWI sequence, prior to needle biopsy or surgery. cDWIs with higher b-values of 1500, 2000, 2500, 3000, 3500, and 4000 s/mm2, and vcDWI were generated from measured (m) DWI with two lower b-values of 0/600, 0/800, or 0/1000 s/mm2. The signal-to-noise ratio (SNR) and contrast ratio (CR) of all image sets were computed and compared among different DWIs by two experienced radiologists independently. To better compare the CR with the SNR, the CR value was multiplied by 100 (CR100). Results: The CR of vcDWI, and cDWIs, except for cDWI1000, differed significantly from that of measured diffusion-weighted imaging (mDWI) (cDWI1000: CR = 0.4904, p = 0.394; cDWI1500: CR = 0.5503, p = 0.006; cDWI2000: CR = 0.5889, p < 0.001; cDWI2500: CR = 0.6109, p < 0.001; cDWI3000: mean = 0.6214, p < 0.001; cDWI3500: CR = 0.6245, p < 0.001; cDWI4000: CR = 0.6228, p < 0.001). The vcDWI provided the highest CR, while the CRs of all cDWI image sets improved with increased b-values. The SNR of neither cDWI1000 nor vcDWI differed significantly from that of mDWI, but the mean SNRs of the remaining cDWIs were significantly lower than that of mDWI. The SNRs of cDWIs declined with increasing b-values, and the initial decrease at low b-values was steeper than the gradual attenuation at higher b-values; the CR100 rose gradually, and the two converged on the b-value interval of 1500–2000 s/mm2 . Conclusions: The highest CR was achieved with vcDWI; this could be a promising approach easier detection of breast cancer. Advances in knowledge: This study comprehensively compared and evaluated the value of the emerging post-processing DWI techniques (including a set of cDWIs and vcDWI) in breast cancer.

The Diagnosis of Early Cerebral Infarction Ischemic Penumbra in Compression Sensing Magnetic Resonance Diffusion Weighted Imaging and Perfusion Weighted Imaging (Preprint)

2020 ◽  
Author(s):  
Hui Sheng ◽  
Xueling Wang ◽  
Meiping Jiang ◽  
Zhongsheng Zhang ◽  
Joh Nowen
Keyword(s):  
Magnetic Resonance ◽  
Cerebral Infarction ◽  
Diffusion Weighted Imaging ◽  
B Value ◽  
Ischemic Penumbra ◽  
Resonance Imaging ◽  
Perfusion Weighted Imaging ◽  
Apparent Diffusion ◽  
Adc Values ◽  
Compression Sensing

UNSTRUCTURED To investigate the diagnostic effect of compression-sensing-based magnetic resonance diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI) on the ischemic penumbra (IP) of early cerebral infarction in New Zealand rabbits, the New Zealand rabbit was selected as the research object, which was divided into the experiment group and the control group by constructing animal models. Rabbit models in both groups were subjected to magnetic resonance imaging (MRI) scans at different time nodes for the examination and observation of relevant indicators. In addition, the brain tissues of each group of rabbits were further stained and analyzed. The comparative analysis results of forehead cortex and basal ganglia in rabbit models indicated that with the increase of b value (the diffusion sensitivity coefficient of magnetic resonance), the signal of the frontal cortex was weakened, while the signal of the basal ganglia was enhanced; in addition, the overall image was gradually blurred, and the signal-to-noise ratio was increasing. The comparison results of signal intensity indicated that the larger the b value was, the more obvious the signal enhancement was. The analysis results of the changes in values of apparent diffusion coefficient (ADC) and the relative apparent diffusion coefficient (rADC) indicated that in the central lesion side of the basal node abnormal signals, the ADC and the rADC values first increased then decreased as the time increased. In addition, the ADC values in the mismatched area of DWI and PWI decreased to zero 6 h after cerebral ischemia, indicating that 6 h after ischemia, the sizes of DWI and PWI were the same, and the mismatched area disappeared. Further pathological examinations showed that with the increase of ischemia time, the neuronal deformation became more apparent. In addition, the mitochondrial membrane was lysed. Eventually, the mitochondria of vascular endothelial cells also showed edema, and the sputum disappeared. Compared with the traditional method, the dynamic magnetic resonance imaging method based on the compression sensing theory could better reconstruct the dynamic magnetic resonance images. Therefore, the experimental results suggested that the b value had obvious effects on the early detection and treatment of cerebral infarction. In addition, the existence of IP could be inferred based on ADC values. Despite the deficiencies in the experimental process, the results have provided experimental evidence for the clinical treatment of cerebral infarction diseases in the future.

Early Analysis of Acute Cerebral Infarction by Magnetic Resonance Diffusion Weighted Imaging

2019 ◽  
Vol 9 (2) ◽  
pp. 293-296
Author(s):  
Benju Liang ◽  
Lan Xia ◽  
Juan Su ◽  
Yaoyao Xu ◽  
Liping Chu ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cerebral Infarction ◽  
Diffusion Weighted Imaging ◽  
Acute Stage ◽  
Acute Cerebral Infarction ◽  
High Signal ◽  
Early Analysis ◽  
Adc Value ◽  
Conventional Mri ◽  
Diffusion Weighted

Objective: The mortality and disability rate of cerebral infarction are high. Early diagnosis and early treatment can improve the prognosis of patients. Conventional computed tomography (CT) and magnetic resonance imaging (MRI) is lack of sufficient sensitivity. The purpose of this study was to investigate the effect of MRI diffusion weighted imaging (DWI) in the early analysis of acute cerebral infarction. Methods: Forty patients with acute cerebral infarction admitted to the Second Affiliated Hospital of Anhui Medical University were examined in this study. With the cooperation of nursing staff, the routine MRI scan sequence and DWI was performed. The ADC values were analyzed and compared in different patients. Results: All the patients completed the examination successfully. In conventional MRI, equal signal was found in hyperacute cerebral infarction, while high signal on T2WI was found in 66% of patients with acute cerebral infarction. Both hyperacute and acute cerebral infarction showed the high signal in DWI. Compared with the contralateral normal tissues, the ADC value in cerebral infarction area was significantly decreased, especially in patients with hyperacute cerebral infarction. Conclusions: The nursing cooperation is helpful for the MRI examination. The DWI is more sensitive than conventional MRI in the analysis of acute cerebral infarction and can distinguish the hyperacute and acute stage, thus providing evidence for effective individualized treatment of patients.

scholarly journals Integrated slice-specific dynamic shimming diffusion weighted imaging (DWI) for rectal Cancer detection and characterization

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Jianxing Qiu ◽  
Jing Liu ◽  
Zhongxu Bi ◽  
Xiaowei Sun ◽  
Xin Wang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Image Quality ◽  
Diffusion Weighted Imaging ◽  
Rectal Tumor ◽  
B Values ◽  
Primary Rectal Cancer ◽  
Diffusion Weighted ◽  
Adc Values ◽  
Group 2 ◽  
Group 1

Abstract Purpose To compare integrated slice-specific dynamic shimming (iShim) diffusion weighted imaging (DWI) and single-shot echo-planar imaging (SS-EPI) DWI in image quality and pathological characterization of rectal cancer. Materials and methods A total of 193 consecutive rectal tumor patients were enrolled for retrospective analysis. Among them, 101 patients underwent iShim-DWI (b = 0, 800, and 1600 s/mm2) and 92 patients underwent SS-EPI-DWI (b = 0, and 1000 s/mm2). Qualitative analyses of both DWI techniques was performed by two independent readers; including adequate fat suppression, the presence of artifacts and image quality. Quantitative analysis was performed by calculating standard deviation (SD) of the gluteus maximus, signal intensity (SI) of lesion and residual normal rectal wall, apparent diffusion coefficient (ADC) values (generated by b values of 0, 800 and 1600 s/mm2 for iShim-DWI, and by b values of 0 and 1000 s/mm2 for SS-EPI-DWI) and image quality parameters, such as signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of primary rectal tumor. For the primary rectal cancer, two pathological groups were divided according to pathological results: Group 1 (well-differentiated) and Group 2 (poorly differentiated). Statistical analyses were performed with p < 0.05 as significant difference. Results Compared with SS-EPI-DWI, significantly higher scores of image quality were obtained in iShim-DWI cases (P < 0.001). The SDbackground was significantly reduced on b = 1600 s/mm2 images and ADC maps of iShim-DWI. Both SNR and CNR of b = 800 s/mm2 and b = 1600 s/mm2 images in iShim-DWI were higher than those of b = 1000 s/mm2 images in SS-EPI-DWI. In primary rectal cancer of iShim-DWI cohort, SIlesion was significantly higher than SIrectum in both b = 800 and 1600 s/mm2 images. ADC values were significantly lower in Group 2 (0.732 ± 0.08) × 10− 3 mm2/s) than those in Group 1 ((0.912 ± 0.21) × 10− 3 mm2/s). ROC analyses showed significance of ADC values and SIlesion between the two groups. Conclusion iShim-DWI with b values of 0, 800 and 1600 s/mm2 is a promising technique of high image quality in rectal tumor imaging, and has potential ability to differentiate rectal cancer from normal wall and predicting pathological characterization.

Sign in / Sign up

Export Citation Format

Share Document