D-Glucuronic Acid-Coated Ultrasmall Bi2O3 Nanoparticles for CT Imaging

2020 ◽  
Vol 20 (8) ◽  
pp. 4638-4642
Author(s):  
Adibehalsadat Ghazanfari ◽  
Shanti Marasini ◽  
Huan Yue ◽  
Son Long Ho ◽  
Xu Miao ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Glucuronic Acid ◽  
Number Density ◽  
Atomic Concentration ◽  
Attenuation Coefficients ◽  
X Ray ◽  
Ct Contrast Agent ◽  
One Step ◽  
First Time ◽  
Ct Contrast

Ultrasmall Bi2O3 nanoparticles (davg = 1.5 nm) coated with biocompatible and hydrophilic D-glucuronic acid were prepared for the first time through a simple one-step polyol process and their potential as CT contrast agents were investigated by measuring their X-ray attenuation properties. Their observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent at the same atomic concentration, as consistent with the magnitudes of atomic X-ray attenuation coefficients (i.e., Bi > I), and much stronger at the same number density. The results indicate that the nanoparticle sample is a potential CT contrast agent.

X-ray Attenuation Properties of Ultrasmall Yb2O3 Nanoparticles as a High-Performance CT Contrast Agent

2019 ◽  
Vol 74 (3) ◽  
pp. 286-291 ◽  
Author(s):  
Adibehalsadat Ghazanfari ◽  
Shanti Marasini ◽  
Tirusew Tegafaw ◽  
Son Long Ho ◽  
Xu Miao ◽  
...  
Keyword(s):  
Contrast Agent ◽  
High Performance ◽  
X Ray ◽  
Ct Contrast Agent ◽  
Ct Contrast

Contrast enhancement of iohexol-cisplatin-gelatin complex under computed tomography imaging

2014 ◽  
Vol 34 (3) ◽  
pp. 267-271
Author(s):  
Wei-Hung Liu ◽  
Yang-Kao Wang ◽  
Chi-Chang Wu ◽  
Win-Pin Deng ◽  
Kuang-Hsun Lin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agent ◽  
Diagnostic Techniques ◽  
The Body ◽  
X Ray ◽  
Non Invasive ◽  
Ct Contrast Agent ◽  
X Ray Computed ◽  
Ct Contrast

Abstract X-ray computed tomography (CT) is one of the most powerful non-invasive diagnostic techniques nowadays. The iodinated molecules used as CT contrast agents in the clinic have short circulation times in the body, which significantly restrict its applications. Furthermore, some patients are hypersensitive to iodine. So, researchers have made tremendous efforts to improve the property of iodine. Besides, cis-diammineplatinum (II) dichloride (cisplatin), a major chemo agent for cancer treatment, possess higher X-ray attenuation coefficient being a CT contrast agent. The incorporation of cisplatin with an iodinated agent could facilitate the quality of CT images and damage cancer cells simultaneously. To reduce toxicity of a contrast agent, polymer matrix, gelatin, was incorporated for avoiding contact with nontarget cells. In this study, we combined the iodine contrast agent, 1,3-N-bis (2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide (iohexol), with cisplatin, and then examined them in a micro CT with different X-ray tube voltages (50 kV, 80 kV, 100 kV) to find optimal scanning conditions for imaging. As expected, iohexol combined with cisplatin enhanced X-ray attenuation and image contrast. The optimal CT image could be acquired at iohexol and cisplatin concentrations of 50 mg/ml and 3 mg/ml, respectively, under 80 kV irradiation. Finally, the iohexol-cisplatin-gelatin solution was then fabricated into nanoparticles of sizes about 240 nm, which may suitable for in vivo delivery.

scholarly journals Synthesis, characterization, in vitro phantom imaging, and cytotoxicity of a novel graphene-based multimodal magnetic resonance imaging-X-ray computed tomography contrast agent

2014 ◽  
Vol 2 (22) ◽  
pp. 3519-3530 ◽  
Author(s):  
Gaurav Lalwani ◽  
Joe Livingston Sundararaj ◽  
Kenneth Schaefer ◽  
Terry Button ◽  
Balaji Sitharaman
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Contrast Agent ◽  
Resonance Imaging ◽  
X Ray ◽  
Ct Contrast Agent ◽  
X Ray Computed ◽  
Multimodal Mri ◽  
Ct Contrast

Development of a novel graphene-based multimodal MRI-CT contrast agent.

SU-E-I-13: A Model for CT Contrast Agent Evaluation

2011 ◽  
Vol 38 (6Part4) ◽  
pp. 3398-3398
Author(s):  
M Bonvento ◽  
S Jambawalikar ◽  
T Button
Keyword(s):  
Contrast Agent ◽  
Ct Contrast Agent ◽  
Ct Contrast

cRGD-modified and disulfide bond-crosslinked polymer nanoparticles based on iopamidol as a tumor-targeted CT contrast agent

2020 ◽  
Vol 11 (4) ◽  
pp. 889-899 ◽  
Author(s):  
Chunhui Gao ◽  
Yinghua Zhang ◽  
Yan Zhang ◽  
Shaoyong Li ◽  
Xinlin Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Contrast Agent ◽  
Disulfide Bond ◽  
Polymer Nanoparticles ◽  
Targeted Imaging ◽  
Crosslinked Polymer ◽  
Ct Contrast Agent ◽  
Surface Modified ◽  
Ct Contrast

The disulfide bond-crosslinked polymer nanoparticles based on iopamidol were prepared and then surface-modified with cRGD peptide through the linkages of PEG to acquire a CT contrast agent for breast cancer-targeted imaging.

An assessment of Gd-DTPA as a CT contrast agent in the renal tract

1993 ◽  
Vol 47 (4) ◽  
pp. 278-279 ◽  
Author(s):  
R.J. Gibson ◽  
C.I. Meanock ◽  
E.P.H. Torrie ◽  
T.M. Walker
Keyword(s):  
Contrast Agent ◽  
Ct Contrast Agent ◽  
Ct Contrast

Gadolinium as a CT Contrast Agent: Assessment in a Porcine Model

Radiology ◽  
1999 ◽  
Vol 210 (3) ◽  
pp. 829-834 ◽  
Author(s):  
David S. Gierada ◽  
Kyongtae T. Bae
Keyword(s):  
Contrast Agent ◽  
Porcine Model ◽  
Ct Contrast Agent ◽  
Ct Contrast
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