Extracellular Nucleotides and Interleukin-8 Production by ARPE Cells: Potential Role of Danger Signals in Blood–Retinal Barrier Activation

2009 ◽  
Vol 50 (3) ◽  
pp. 1241 ◽  
Author(s):  
Lia Judice M. Relvas ◽  
Christophe Bouffioux ◽  
Brice Marcet ◽  
Didier Communi ◽  
Maya Makhoul ◽  
...  
Keyword(s):  
Potential Role ◽  
Interleukin 8 ◽  
Extracellular Nucleotides ◽  
Blood Retinal Barrier ◽  
Danger Signals

The potential role of Interleukin-8 in human malignant mesothelioma progression

Lung Cancer ◽  
1999 ◽  
Vol 25 ◽  
pp. S25 ◽  
Author(s):  
Gabriella GaIffy ◽  
Kamal A. Mohammed ◽  
Patrick A. Dowling ◽  
Najmunnisa Nasreen ◽  
Melissa J. Ward ◽  
...  
Keyword(s):  
Malignant Mesothelioma ◽  
Potential Role ◽  
Interleukin 8

scholarly journals Viral infection and neurological disorders—potential role of extracellular nucleotides in neuroinflammation

ExRNA ◽  
2019 ◽  
Vol 1 (1) ◽  
Author(s):  
Liang Li ◽  
Susu Mao ◽  
Jin Wang ◽  
Xin Ding ◽  
Jane Y. Zen
Keyword(s):  
Viral Infection ◽  
Neurological Disorders ◽  
Potential Role ◽  
Extracellular Nucleotides

The Potential Role of Neutrophils in Promoting the Metastatic Phenotype of Tumors Releasing Interleukin-8

2004 ◽  
Vol 10 (15) ◽  
pp. 4895-4900 ◽  
Author(s):  
Joseph E. De Larco ◽  
Beverly R. K. Wuertz ◽  
Leo T. Furcht
Keyword(s):  
Potential Role ◽  
Interleukin 8 ◽  
Metastatic Phenotype

scholarly journals Involvement of Cytokines in the Pathogenesis of Diabetic Macular Edema

2021 ◽  
Vol 22 (7) ◽  
pp. 3427
Author(s):  
Hidetaka Noma ◽  
Kanako Yasuda ◽  
Masahiko Shimura
Keyword(s):  
Macular Edema ◽  
Diabetic Macular Edema ◽  
Potential Role ◽  
Vascular Endothelial ◽  
Blood Retinal Barrier ◽  
Feedback Mechanisms ◽  
Novel Treatments ◽  
Endothelial Growth Factor ◽  
Consequent Increase

Diabetic macular edema (DME) is a critical complication of diabetic retinopathy, a condition that arises from the breakdown of the blood–retinal barrier and the consequent increase in vascular permeability. Over the years, attempts have been made to treat DME by various approaches, including laser photocoagulation, steroid triamcinolone acetonide, and vitrectomy. However, treatment was unsatisfactory until research identified vascular endothelial growth factor (VEGF) as a factor in the pathogenesis of DME. Intraocular anti-VEGF agents show good efficacy in DME. Nevertheless, in some patients the condition recurs or becomes resistant to treatment, suggesting that other factors may be involved. Because inflammation and retinal hypoxia are seen in DME, research has examined the potential role of cytokines and other inflammatory mediators. In this review, we provide an overview of this research and describe feedback mechanisms that may represent a target for novel treatments.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

1255: Potential Role of Postoperative Azotemia in Predicting Response to Interleukin-2 (IL-2) Immunotherapy Following Cytoreductive Nephrectomy for Metastatic Renal Cell Carcinoma

2007 ◽  
Vol 177 (4S) ◽  
pp. 414-414
Author(s):  
John S. Lam ◽  
Rakhee H. Gael ◽  
Tobias Klatte ◽  
Fairooz F. Kabbinavar ◽  
Arie S. Belldegrun ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Potential Role ◽  
Interleukin 2 ◽  
Cytoreductive Nephrectomy

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

The Potential Role of the Cytochrome P-450 2D6 Pharmacogenetic Polymorphism in Drug Abuse

1997 ◽  
Author(s):  
Edward M. Sellers ◽  
S. Victoria Otton ◽  
Rachel F. Tyndale
Keyword(s):  
Drug Abuse ◽  
Potential Role ◽  
Cytochrome P 450

Potential Role of Sex-Steroid Depletion in Dementia: Implications for Treatment

2009 ◽  
Author(s):  
Channing Harris
Keyword(s):  
Potential Role ◽  
Sex Steroid
Sign in / Sign up

Export Citation Format

Share Document