Quantitative Analysis of the Ellipsoid Zone Intensity in Phenotypic Variations of Intermediate Age-Related Macular Degeneration

Purpose: To report the clinical findings in patients ≥100 years old who have age-related macular degeneration (AMD). Methods: We identified patients ≥100 years old who had non-neovascular AMD, neovascular AMD or both. Results: Sixty-two patients were included. The mean (SD) age was 102 (1.4) years (range, 100-106 years). Most patients were white (n = 51, 82%), women (n = 51, 82%), and had at least 1 eye affected by neovascular AMD (n = 55, 89%). The mean Snellen visual acuity (VA) among eyes with neovascular AMD was worse than that for eyes with non-neovascular AMD (20/600 [range, 20/40-hand motions] vs 20/250 [range, 20/20-hand motions], respectively, P = .03). Eyes with an intact subfoveal ellipsoid zone (EZ) had much better mean VA than eyes with an absent or disrupted EZ (20/50 vs 20/500, P = .002). Conclusion: Most centenarians with AMD in our cohort had the neovascular form, and these individuals tended to have poorer vision than those with non-neovascular AMD. The presence of an intact subfoveal EZ is associated with better VA in eyes with neovascular or non-neovascular AMD compared to eyes with an absent or disrupted EZ.

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Quantitative Analysis of Outer Retinal Tubulation in Age-Related Macular Degeneration From Spectral-Domain Optical Coherence Tomography and Histology

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.16-19262 ◽

2016 ◽

Vol 57 (6) ◽

pp. 2647 ◽

Cited By ~ 19

Author(s):

Katie M. Litts ◽

Thomas Ach ◽

Kristen M. Hammack ◽

Kenneth R. Sloan ◽

Yuhua Zhang ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Quantitative Analysis ◽

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Spectral Domain ◽

Optical Coherence ◽

Age Related ◽

Outer Retinal Tubulation

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Predictors of functional outcome of antiangiogenic therapy in neovascular age-related macular degeneration

Ophthalmology journal ◽

10.17816/ov46198 ◽

2020 ◽

Vol 13 (4) ◽

pp. 7-13

Author(s):

Alexandr S. Kharakozov ◽

Alexey N. Kulikov ◽

Dmitrii S. Maltsev

Keyword(s):

Visual Acuity ◽

Macular Degeneration ◽

Functional Outcome ◽

Disease Duration ◽

Antiangiogenic Therapy ◽

Age Related Macular Degeneration ◽

Ellipsoid Zone ◽

Age Related ◽

Treatment Naïve

Aim.To study predictive factors for functional outcome of aflibercept intravitreal antiangiogenic therapy in patients with neovascular age-related macular degeneration (nAMD). Material and methods.Thirty-six treatment naive nAMD patients (45 eyes, 26 females and 10 males, with a mean age of 74.4 10.9 years) were included in this study. All patients received 3 monthly aflibercept injections followed by 4 bimonthly aflibercept injections. Demographic characteristics, baseline best corrected visual acuity (BCVA), central retinal thickness (CRT), and structural retinal changes on optical coherence tomography (OCT) scans were evaluated for the correlation with BCVA after 10 months follow-up. Results.At the end of the follow-up period, the mean BCVA increased statistically significantly from 31 15 (~0.32) letters at baseline to 37 14 (~0.4) letters (p= 0.003). CRT at baseline and at the end of follow-up was 357 110 and 269 70 m (p 0.001), respectively. Final BCVA correlated statistically significantly with baseline BCVA (r= 0.62,p 0.0001), baseline CRT (r= 0.48,p= 0.001), and disease duration from the appearance of complaints until the therapy start (r= 0.32,p= 0.03). Structural macular changes on the OCT scans were not related to final BCVA (p 0.05) apart from the status of the ellipsoid zone (p 0.001). Final BCVA was statistically significantly lower in males than in females (34.7 14.0 (~0.4) and 45.0 9.2 (~0.63) letters, respectively,p= 0.03). Conclusion.Baseline visual acuity, gender, CRT, disease duration from the appearance of complaints until the therapy start, and status of the ellipsoid zone are predictive for the functional outcome in wet AMD patients.

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Interactive retinal blood flow estimation from fluorescein angiograms

Proceedings of the Institution of Mechanical Engineers Part C Journal of Mechanical Engineering Science ◽

10.1177/0954406211435195 ◽

2012 ◽

Vol 226 (10) ◽

pp. 2521-2537 ◽

Cited By ~ 3

Author(s):

Rubiel Vargas Cañas ◽

Panos Liatsis

Keyword(s):

Blood Flow ◽

Quantitative Analysis ◽

Macular Degeneration ◽

Transit Time ◽

Age Related Macular Degeneration ◽

Retinal Blood Flow ◽

Prototype System ◽

Flow Estimation ◽

Age Related ◽

Segmentation Image

It is well-known that age-related macular degeneration is the main cause of visual impairment in industrialised countries affecting around 239,000 people in UK while demonstrating an increasing trend. Fluorescein angiography is the most widely used technique in the diagnosis, prognosis and in following up the development of the disease. The interpretation of fluorescein angiograms depends upon the detection of abnormal fluorescence and clinical assessment of the functional integrity of retinal circulation, which is primarily based on subjective evaluation of the dye transit-time. This study presents a prototype system for quantitative analysis of the retinal haemodynamics. It analyses retinal blood flow based on the estimation of parameters such as mean transit-time, arteriovenous passage time and mean dye velocity. These parameters are estimated using densitometry and analysis of the vascular response. The prototype system consists of three main stages: vessel segmentation, image registration and blood flow estimation. The performance of the system is demonstrated on a comprehensive dataset, which contains images of normal retinas and retinas with pathologies such as wet age-related macular degeneration and branch retinal vein occlusion. The presented framework aims to demonstrate the technical feasibility for automated extraction of retinal blood flow parameters and contributes towards the development of a clinically proven computer vision system for quantitative analysis of fluorescein angiograms to assist NHS clinicians in the early diagnosis of age-related macular degeneration.

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