Age-Related Changes of the Human Crystalline Lens on High-Spatial Resolution Three-Dimensional T1-Weighted Brain Magnetic Resonance Images In Vivo

AbstractThe human subcortex comprises hundreds of unique structures. Subcortical functioning is crucial for behavior, and disrupted subcortical function is observed in common neurodegenerative diseases. Despite their importance, human subcortical structures continue to be difficult to study in vivo. Here, we zoom in on 17 prominent subcortical structures, by describing their approximate iron and myelin contents and thickness, and by providing detailed accounts of their age-related changes across the normal adult lifespan. The results provide compelling insights into the highly heterogeneous morphometry and intricate age-related variations of these structures. They also show that the locations of these structures shift across the lifespan, which is of direct relevance for the use of standard magnetic resonance imaging atlases. The results further our understanding of subcortical morphometry and neuroimaging properties, and of normal aging processes which ultimately can improve understanding of neurodegeneration.

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Estimating the spatial resolution of in vivo magnetic resonance images using radiofrequency tagging pulses

Magnetic Resonance in Medicine ◽

10.1002/mrm.21257 ◽

2007 ◽

Vol 58 (1) ◽

pp. 190-199 ◽

Cited By ~ 4

Author(s):

Wen-Tung Wang ◽

Peng Hu ◽

Craig H. Meyer

Keyword(s):

Magnetic Resonance ◽

Spatial Resolution ◽

Magnetic Resonance Images

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Age-Related Changes in Myocardial Relaxation Using Three-Dimensional Tagged Magnetic Resonance Imaging

Journal of Cardiovascular Magnetic Resonance ◽

10.1081/jcmr-120022258 ◽

2003 ◽

Vol 5 (3) ◽

pp. 421-430 ◽

Cited By ~ 74

Author(s):

Helen C. Oxenham* ◽

Alistair A. Young ◽

Brett R. Cowan ◽

Thomas L. Gentles ◽

Christopher J. Occleshaw ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Magnetic Resonance ◽

Three Dimensional ◽

Resonance Imaging ◽

Myocardial Relaxation ◽

Age Related ◽

Tagged Magnetic Resonance Imaging ◽

Age Related Changes

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Clinical applications of three-dimensional magnetic resonance image analysis

Journal of the American Podiatric Medical Association ◽

10.7547/87507315-86-1-33 ◽

1996 ◽

Vol 86 (1) ◽

pp. 33-37 ◽

Cited By ~ 6

Author(s):

GR Bauer ◽

HJ Hillstrom ◽

JK Udupa ◽

BE Hirsch

Keyword(s):

Magnetic Resonance ◽

Surgical Planning ◽

Three Dimensional ◽

Magnetic Resonance Images ◽

Application Development ◽

Dimensional Reconstruction ◽

Foot Function ◽

Broad Clinical Application

A methodology for measuring the kinematic parameters of joints in vivo has been refined using the technique of computerized three-dimensional reconstruction from magnetic resonance images. A research protocol has been developed to establish a classification of normal and pathologic foot function that will have broad clinical application. Development of algorithms for a computer-directed program that can predict resultant kinematics and joint morphometry for a given osteotomy or osseous remodeling procedure will assist the surgeon in preoperative surgical planning.

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