scholarly journals BCG vaccination reduces the mortality of Mycobacterium tuberculosis–infected type 2 diabetes mellitus mice

JCI Insight ◽  
2020 ◽  
Vol 5 (5) ◽  
Author(s):  
Rajesh Kumar Radhakrishnan ◽  
Ramya Sivangala Thandi ◽  
Deepak Tripathi ◽  
Padmaja Paidipally ◽  
Madeline Kay McAllister ◽  
...  
2019 ◽  
Vol 15 (12) ◽  
pp. e1008140 ◽  
Author(s):  
Deepak Tripathi ◽  
Rajesh Kumar Radhakrishnan ◽  
Ramya Sivangala Thandi ◽  
Padmaja Paidipally ◽  
Kamakshi Prudhula Devalraju ◽  
...  

Author(s):  
Vishwanath Venketaraman ◽  
Aram Yegiazaryan

Uncontrolled Type 2 diabetes is associated with altered metabolism resulting in microvascular and macrovascular diseases and enhanced susceptibility to Mycobacterium tuberculosis infection.


2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Himyatul Hidayah ◽  
Surya Amal

Penyakit tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh Mycobacterium tuberculosis, menjadi penyakit infeksi penyebab kematian kedua di dunia setelah HIV-AIDS. Prevalensi kejadian TB di Indonesia menempati urutan ketiga setelah India dan China. Diabetes mellitus diperkirakan penyebab 15% kasus tuberkulosis saat ini, karena penyakit diabetes mellitus dapat merusak pertahanan host. Tujuan penelitian ini untuk mengetahui insidensi TB paru kasus baru dengan DM tipe 2 di salah satu rumah sakit swasta Cikampek. Instrumen penelitian yang digunakan adalah data sekunder rekam medik pasien TB paru kasus baru yang menjalani rawat jalan selama bulan April – September 2017 di Poli Penyakit Dalam salah satu rumah sakit swasta Cikampek. Hasil penelitian ini menunjukkan bahwa dari 83 pasien TB paru kasus baru terdapat 26 pasien TB paru kasus baru dengan DM Tipe 2.  Frekuensi TB paru kasus baru dengan DM tipe 2 lebih banyak pada kelompok jenis kelamin perempuan (53,85%), usia >54 tahun (65,39%), hasil pemeriksaan BTA sputum negatif (61,50%), lamanya pengobatan yang dianjurkan >8 bulan (53,85%).  Disimpulkan bahwa insidensi tuberkulosis paru kasus baru dengan DM tipe 2 rawat jalan di Poli Penyakit Dalam salah satu rumah sakit swasta Cikampek selama bulan April – September 2017 adalah sebesar 31,33%. Kata Kunci: Insidensi, Tuberkulosis paru, Diabetes mellitus tipe 2 Tuberculosis (TB) is an infectious disease caused by mycobacterium tuberculosis, it became the second leading cause of death in the world after HIV-AIDS. The prevalence of incidence of TB in Indonesia ranked third after India and China. Diabetes mellitus thought to be the cause 15 % the case of tuberculosis at the present time, due to disease of diabetes mellitus can be damaging to defense host. The purpose of this study was to know the incidence of new cases of pulmonary TB with type 2 diabetes mellitus in one of the private hospital Cikampek. The research instrument used was secondary data from the medical records of new TB pulmonary outpatients during April - September 2017 in the polyclinic internal medicine in one of the private hospital Cikampek. The result of study indicate that of the 83 new cases of pulmonary tuberculosis patients there were 26 new cases of pulmonary tuberculosis patients with type 2 diabetes mellitus. The frequency of pulmonary tuberculosis a new case with type 2 DM be greater among a group of the female sex (53,85 %), the age of >54 years (65,39%), results smear sputum negative (61,50%), length of treatment recommended >8 months (53,85%). It was concluded that the incidence of new cases of pulmonary TB with type 2 diabetes mellitus outpatients care in one of the private hospital Cikampek during the month of April – September2017 was recorded at 31,33 %. Keywords: Incidence, Pulmonary tuberculosis, Type 2 diabetes mellitus


2019 ◽  
Vol 8 (12) ◽  
pp. 2219 ◽  
Author(s):  
Steve Ferlita ◽  
Aram Yegiazaryan ◽  
Navid Noori ◽  
Gagandeep Lal ◽  
Timothy Nguyen ◽  
...  

There has been an alarming increase in the incidence of Type 2 Diabetes Mellitus (T2DM) worldwide. Uncontrolled T2DM can lead to alterations in the immune system, increasing the risk of susceptibility to infections such as Mycobacterium tuberculosis (M. tb). Altered immune responses could be attributed to factors such as the elevated glucose concentration, leading to the production of Advanced Glycation End products (AGE) and the constant inflammation, associated with T2DM. This production of AGE leads to the generation of reactive oxygen species (ROS), the use of the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) via the Polyol pathway, and overall diminished levels of glutathione (GSH) and GSH-producing enzymes in T2DM patients, which alters the cytokine profile and changes the immune responses within these patients. Thus, an understanding of the intricate pathways responsible for the pathogenesis and complications in T2DM, and the development of strategies to enhance the immune system, are both urgently needed to prevent co-infections and co-morbidities in individuals with T2DM.


2015 ◽  
Vol 21 ◽  
pp. 280-281
Author(s):  
Medha Munshi ◽  
Jasvinder Gill ◽  
Jason Chao ◽  
Elena Nikonova ◽  
Andreas Stuhr ◽  
...  

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