Comparison of acid fast bacilli (AFB) smear for Mycobacterium tuberculosis on adult pulmonary tuberculosis (TB) patients with type 2 diabetes mellitus (DM) and without type 2 DM

Penyakit tuberkulosis (TB) merupakan penyakit menular yang disebabkan oleh Mycobacterium tuberculosis, menjadi penyakit infeksi penyebab kematian kedua di dunia setelah HIV-AIDS. Prevalensi kejadian TB di Indonesia menempati urutan ketiga setelah India dan China. Diabetes mellitus diperkirakan penyebab 15% kasus tuberkulosis saat ini, karena penyakit diabetes mellitus dapat merusak pertahanan host. Tujuan penelitian ini untuk mengetahui insidensi TB paru kasus baru dengan DM tipe 2 di salah satu rumah sakit swasta Cikampek. Instrumen penelitian yang digunakan adalah data sekunder rekam medik pasien TB paru kasus baru yang menjalani rawat jalan selama bulan April – September 2017 di Poli Penyakit Dalam salah satu rumah sakit swasta Cikampek. Hasil penelitian ini menunjukkan bahwa dari 83 pasien TB paru kasus baru terdapat 26 pasien TB paru kasus baru dengan DM Tipe 2. Frekuensi TB paru kasus baru dengan DM tipe 2 lebih banyak pada kelompok jenis kelamin perempuan (53,85%), usia >54 tahun (65,39%), hasil pemeriksaan BTA sputum negatif (61,50%), lamanya pengobatan yang dianjurkan >8 bulan (53,85%). Disimpulkan bahwa insidensi tuberkulosis paru kasus baru dengan DM tipe 2 rawat jalan di Poli Penyakit Dalam salah satu rumah sakit swasta Cikampek selama bulan April – September 2017 adalah sebesar 31,33%. Kata Kunci: Insidensi, Tuberkulosis paru, Diabetes mellitus tipe 2 Tuberculosis (TB) is an infectious disease caused by mycobacterium tuberculosis, it became the second leading cause of death in the world after HIV-AIDS. The prevalence of incidence of TB in Indonesia ranked third after India and China. Diabetes mellitus thought to be the cause 15 % the case of tuberculosis at the present time, due to disease of diabetes mellitus can be damaging to defense host. The purpose of this study was to know the incidence of new cases of pulmonary TB with type 2 diabetes mellitus in one of the private hospital Cikampek. The research instrument used was secondary data from the medical records of new TB pulmonary outpatients during April - September 2017 in the polyclinic internal medicine in one of the private hospital Cikampek. The result of study indicate that of the 83 new cases of pulmonary tuberculosis patients there were 26 new cases of pulmonary tuberculosis patients with type 2 diabetes mellitus. The frequency of pulmonary tuberculosis a new case with type 2 DM be greater among a group of the female sex (53,85 %), the age of >54 years (65,39%), results smear sputum negative (61,50%), length of treatment recommended >8 months (53,85%). It was concluded that the incidence of new cases of pulmonary TB with type 2 diabetes mellitus outpatients care in one of the private hospital Cikampek during the month of April – September2017 was recorded at 31,33 %. Keywords: Incidence, Pulmonary tuberculosis, Type 2 diabetes mellitus

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Profile of Pulmonary Tuberculosis Patients with Type 2 Diabetes Mellitus in Pulmonary Department Dr. Soetomo General Hospital Surabaya

Jurnal Respirasi ◽

10.20473/jr.v6-i.2.2020.35-39 ◽

2020 ◽

Vol 6 (2) ◽

pp. 35

Author(s):

Ayu Rahmanita Putri Soetrisno ◽

Rebekah Juniati Setiabudi ◽

Laksmi Wulandari

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Pulmonary Tuberculosis ◽

General Hospital ◽

Cross Sectional ◽

High Blood Glucose ◽

Pulmonary Tb ◽

Type 2 Dm

Background: Pulmonary tuberculosis (TB) is the most important infectious disease, caused by Mycobacterium tuberculosis (MTB). Indonesia is the third country with the most prevalent TB cases in the world. Not all people who were exposed to MTB will become active TB, because the immune response is the main determinant. Immunocompromised person, such as patients who have type 2 diabetes mellitus (DM) as a comorbid are more prone to develop active TB infection. This study aimed to analyze the profile of pulmonary TB patients with type 2 DM in Pulmonary Department Dr. Soetomo General Hospital Surabaya.Methods: This was an observational descriptive study with a cross-sectional design. The research data were obtained from the medical records of TB patients with type 2 DM in Pulmonary Department Dr. Soetomo General Hospital Surabaya in January - December 2017.Results: Out of a total of 414 hospitalized patients, 74 patients with pulmonary TB were found with type 2 DM. Only 53 patients fulfilled the inclusion criteria. Gene Xpert results were sensitive (66.7%), previous TB treatment history (54.7%), unregulated type 2 DM (88.4%), RBG with the average of 311.83 mg/dl, PPBS with the average of 263.31 mg/dl, FBG with the average of 238 mg/dl, and HbA1C > 10% (68%).Conclusion: The majority of the patients of pulmonary TB with type 2 DM have average high blood glucose and unregulated DM.

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Association of Obesity and Negative Acid-Fast Bacilli Founding Among Pulmonary Tuberculosis Patients with Type 2 Diabetes Mellitus

Jurnal Epidemiologi Kesehatan Indonesia ◽

10.7454/epidkes.v3i2.3470 ◽

2020 ◽

Vol 3 (2) ◽

Author(s):

Nadya Magfira ◽

Md Ikhsan Mokoagow ◽

Ida Ayu Kshanti ◽

Helda Nazar

Keyword(s):

Internal Medicine ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Body Mass Index ◽

Type 2 Diabetes Mellitus ◽

Pulmonary Tuberculosis ◽

Smear Microscopy ◽

Tuberculosis Patients ◽

Acid Fast Bacilli

Obesity is known as protective factors of pulmonary tuberculosis (PTB) innon-diabetes mellitus population. However, it’s effect on PTB in type 2diabetes mellitus (T2DM) patient is unclear. The study aims to determinethe association between obesity and PTB in patient with T2DM. A crosssectional study was held in in-patient, The Department of Internal Medicine, Fatmawati General Hospital from January 2015 to December 2017.This study includes patient with T2DM who had been diagnosed with PTBand age > 18 years old. In this study negative Acid-fast-bacilli (AFB)founding defined as patient’s sputum is negative by smear microscopy,while obesity define as body mass index > 24.9 kg/m2. From 363 PTBpatient with T2DM, 22.59% were obese. Results showed that prevalenceof negative AFB founding in PTB patients with T2DM was 81.82% and itwas solely associated with obesity (p:0.002, OR=6.36, 95%CI 1.9-21). Obesepatients were likely to have negative AFB founding. It suggested thatdiagnosing PTB in patient with T2DM and obese can’t be solely based onbacteriological confirmation

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Efektivitas Kurma (Phoenix dactylifera) dalam menurunkan kadar HbA1c pada pasien diabetes mellitus tipe 2: Laporan Kasus Berbasis Bukti

Journal of Pharmaceutical Care Anwar Medika ◽

10.36932/jpcam.v3i1.47 ◽

2020 ◽

Vol 3 (1) ◽

pp. 31-45

Author(s):

Muhammad Sobri Maulana ◽

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Hba1c Level ◽

Phoenix Dactylifera ◽

Herbal Remedies ◽

Cochrane Library ◽

Time Treatment ◽

Type 2 Dm

Type 2 Diabetes Mellitus or Type 2 DM is a metabolic disease that can cause severe complications so that adequate management which one of the targets is lowering HbA1c level is needed. Up to this time, treatment for Type 2 DM including antihiperglycemic and injection. Herbal remedies as well as dates (Phoenix datcylifera) has been limited even though it has well-known antihyperglycemic effect. To investigate the effectivity of Dates (Phoenix dactylifera) in lowering HbA1c level among Type 2 Diabetes Mellitus patients. Literature searching was conducted on four online databases which are PubMed, Scopus, EBSCO, and Cochrane Library based on inclusion and exclusion criterias. Based on the results of critical studies, seven studies have shown that there is effectiveness in the administration of Dates (Phoenix dactylifera) in patients with type 2 diabetes mellitus on Lowering HbA1c levels and restricition of date diet needed for type 2 diabetes mellitus patients in 3 dates per day that are statistically significant for lowering HbA1c level with value of NNT is 1. Administration of Dates (Phoenix dactylifera) can be used as an adjuvant therapy on Type 2 Diabetes mellitus patients

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Correlation Between Lipid Profile with Type 2 Diabetes Mellitus Progression

JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia ◽

10.53366/jimki.v8i2.131 ◽

2020 ◽

Vol 8 (2) ◽

pp. 66-72

Author(s):

Angiesta Pinakesty ◽

Restu Noor Azizah

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Glycemic Control ◽

Lipid Profile ◽

Cholesterol Levels ◽

Type 2 Dm ◽

Hba1c Levels

Introduction: Diabetes mellitus (DM) is a non-communicable disease that has increased from year to year. Type 2 diabetes mellitus is not caused by lack of insulin secretion, but is caused by the failure of the body's cells to respond to the hormone insulin (insulin resistance). Insulin resistance was found to be a major contributor to atherogenic dyslipidemia. Dyslipidemia in DM risks 2 to 4 times higher than non-DM. Although dyslipidemia has a great risk for people with type 2 diabetes mellitus, this conventional risk factor only explains a portion (25%) of excess cardiovascular risk in type 2 DM. Discussion: In uncontrolled type 2 DM patients, LDL oxidation occurs faster which results from an increase in chronic blood glucose levels. Glycemic control as a determinant of DM progressivity is determined through HbA1c examination. HbA1c levels are associated with blood triglyceride levels. Meanwhile, triglyceride levels are associated with total cholesterol and HDL cholesterol levels. HbA1c levels are also associated with LDL cholesterol levels. Conclusion: There is a relationship between lipid profile and the progression of type 2 diabetes mellitus. Keywords: type 2 diabetes mellitus, dyslipidemia, HbA1c, glycemic control, lipid profile

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COMPARATIVE STUDY OF SITAGLIPTINAND PIOGLITAZONE AS ADDONTHERAPY OVER PLASMA GLUCOSE LEVEL IN TYPE 2 DIABETES MELLITUS PATIENTS : AN OBSERVATIONAL COHORT STUDY

10.36106/ijsr/9730816 ◽

2020 ◽

pp. 10-11

Author(s):

Ravindra Kumar Das ◽

Rahul Kumar Sinha ◽

Debarshi Jana

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Plasma Glucose ◽

Plasma Glucose Level ◽

Observational Cohort Study ◽

Type 2 Dm ◽

Observational Cohort ◽

Pioglitazone Group

Background: Type 2 diabetes mellitus (DM) is a progressive chronic disorder and sustained control of plasma glucose is essential to prevent complications. Pioglitazoneofthiazolidinedionesand sitagliptin of Dipeptidyl peptidase-4 inhibitors (DPP4I) have recently been used as add-on therapy to control type 2 DM. The aim of this study was to compare the plasma glucose and glycocelatedHb% level of both the group who had poor glycemic control with Metformin and sulfonylurea. MATERIAL AND METHODS: In this observational cohort study, 100 patients with uncontrolled type 2 DM on 2000 mg/day of Metformin and 4 mg/day of Glimepiride were enrolled. The patients were randomly allocated into two groups with fifty each. One group received two divided doses of pioglitazone (30 mg/day) and the other received two divided doses of sitagliptin (100 mg/day) as the third medication. Plasma glucose fasting and 2 hours after drug and meal along with HbA1c were assessed before and after three months of treatment. Results: Fasting plasma glucose level in the sitagliptin group was higher than the pioglitazone group; however, this difference was not statistically significant (130.30 ± 30.29 versus 124.58 ± 46.84, p=0.212). Significantdifferences were not observed in HbA1c (7.20±0.96 versus 7.43±0.99, p=0.563) and plasma glucose 2 hours after meal (194.56±66.22 versus 198.58±51.5, p=0.946) after treatment withsitagliptin and pioglitazone among the two groups. Mean weight in the sitagliptin group was lower compared to the pioglitazone group after treatment, however, this difference was not statistically significant (p=0.824). Conclusion: Both the molecule as third agent had similar efficacy in glycemic control. Sitagliptin is better choice to add-on therapy in obese overweight patients.

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Type 2 Diabetes Mellitus And Vitamin C

Journal of Bahria University Medical and Dental College ◽

10.51985/jbumdc2019014 ◽

2019 ◽

Vol 09 (03) ◽

pp. 232-236

Author(s):

Shabzain Ishrat ◽

Talea Hoor ◽

Mohammed Sajid Abbas Jaffri

Keyword(s):

Oxidative Stress ◽

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Vitamin C ◽

Good Control ◽

Type 2 Dm ◽

Vitamin C Supplementation ◽

Antioxidant Supplements

Type 2 diabetes mellitus (DM) is a chronic disease which deteriorates the quality of life with time. Type 2 DM accounts for more than 90% cases of diabetes mellitus as compared to other types of this disease. There is significant oxidative stress in type 2 DM which plays an important role in the pathogenesis of disease. In order to combat this oxidative stress antioxidant supplements have to be added as add on therapy along with treatment of type 2 DM. Vitamin C is the safest antioxidant which plays significant role in diminishing the oxidative stress. The vitamin C supplementation have good control of FBS and HbA1c and therefore helps in achieving better glycemic control along with prevention of lipid abnormalities.

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Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in Type 2 Diabetes Mellitus

Journal of Postgraduate Medicine Education and Research ◽

10.5005/jp-journals-10028-1204 ◽

2016 ◽

Vol 50 (3) ◽

pp. 127-131 ◽

Cited By ~ 1

Author(s):

M Bhanukumar ◽

Prasanna KH Ramaswamy ◽

Naveen K Peddi ◽

Vineetha B Menon

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Mean Platelet Volume ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Vascular Thrombosis ◽

Type 2 Dm

ABSTRACT Aims The objective of the study was to determine the mean platelet volume (MPV) and platelet distribution width (PDW) in subjects with type 2 diabetes mellitus (type 2 DM) compared to subjects without type 2 DM and their correlation with fasting blood glucose, glycosylated hemoglobin (HbA1c), and duration of type 2 DM respectively. Materials and methods A prospective analytical case—control study was conducted involving 50 subjects with type 2 DM and 50 subjects without type 2 DM. The mean and standard deviation were estimated for both the groups separately and independent Student's “t”-test was used for evaluating the significant difference. The statistical evaluation was carried out at 95% confidence level. Results Mean MPV and PDW in case group was significantly higher compared to control group (p < 0.005). Fasting blood glucose, HbA1c, and duration of type 2 DM did not significantly alter MPV or PDW. Conclusion The study concludes that MPV and PDW are significantly increased in patients with type 2 DM compared to patients without type 2 DM. Platelet volume indices are an important, simple, and cost-effective tool that should be used and explored extensively, especially in countries, such as India, for predicting the possibility of impending acute vascular events in patients with type 2 DM. Clinical significance This analytical method helps us to use MPV and PDW as early markers of vascular thrombosis. How to cite this article Bhanukumar M, Ramaswamy PKH, Peddi NK, Menon VB. Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in Type 2 Diabetes Mellitus. J Postgrad Med Edu Res 2016;50(3):127-131.

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Relationship of Type 2 Diabetes Mellitus Duration with The Occurrence of Erectile Dysfunction at Puskesmas Denpasar Barat I

Indonesian Andrology and Biomedical Journal ◽

10.20473/iabj.v2i1.45 ◽

2021 ◽

Vol 2 (1) ◽

pp. 23-28

Author(s):

Alexander Petra Sihite ◽

I Gusti Ngurah Pramesemara ◽

I Wayan Surudarma

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Erectile Dysfunction ◽

Cross Sectional ◽

Type 2 Dm ◽

Number Of Patients ◽

Relationship Of ◽

The Relationship

Background: Type 2 diabetes mellitus is a metabolic disease that characterized by high blood sugar levels. This condition is often not noticed immediately and usually patient starting to realize it when complications have been occurred. A long-term complication of type 2 DM that occurred in men is erectile dysfunction (ED). ED is a condition when a person is unable to achieve or maintain an erection for sexual intercourse. One factor that influence the occurrence of ED and its severity in type 2 DM patients is the duration of the disease. Objective: The aim of this study was to determine the relationship of type 2 DM duration and the occurrence of ED. Methods: This study is an observational analytic cross-sectional study conducted at the Puskesmas (Public Health Center) Denpasar Barat I. The research data was obtained through medical record data and fill the International Index of Erectile Function (IIEF-5) questionnaire on 36 type 2 DM patients aged around 40-60 years. The statistical analysis used was Fisher's exact test. Results: The results showed that of the 36 samples, 19 (52.8%) samples had type 2 DM <24 months and 17 (47.2%) samples had type 2 DM >24 months. It was found that 5 (13.9%) samples did not experience ED while the rest experienced ED with different severity. There was a significant relationship between the type 2 DM duration and the occurrence of erectile dysfunction at Puskesmas Denpasar Barat I (p = 0.022). Conclusion: Study has found that type 2 DM patients with the longer duration (>24 months) have a higher occurrence of ED and tended to be more severe compared to those with shorter duration (<24 months). Further studies should be performed with higher number of patients and more controlled risk factor so it will be more accurate in determining the relationship between the duration of type 2 DM and ED.

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Psychological Well Being In Type 2 Diabetes Mellitus Patients In Mulyorejo Public Health Center Surabaya

Jurnal NERS ◽

10.20473/jn.v11i22016.147-156 ◽

2016 ◽

Vol 11 (2) ◽

pp. 147

Author(s):

Rr Dian Tristiana

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Diabetes Mellitus Type 2 ◽

Transition Process ◽

Well Being ◽

Self Control ◽

Psychological Well Being ◽

Type 2 Dm

Introduction: Living with chronic diseases such as Diabetes mellitus type 2 will make patients experience change or imbalance include biological, psychological, social and spiritual. One of psychology aspects in patients with Diabetes mellitus type 2 is psychological well being (PWB). Emotional response of type 2 DM patients since the early diagnosis to begin undergoing the treatment will be different for each person. Type 2 DM patients need a good transition process to achieve well being state. The transition from a healthy to a diseased condition is needed for the successful self care management of type 2 DM patients. The purpose of this research was to explore the description of PWB in patients of type 2 Diabetes mellitus in six aspects of PWB and PWB facilitate and inhibitor factors in type 2 DM patients. Methods: This research used qualitative design research with case studies approach. The subject of research was seven participants who met the inclusion criteria. Data collection was done by structured interview and observation. Data analysis was done by thematic analysis. Result and Analysis: This study generated 14 themes. The result showed that the process of type 2 DM patients subjected to the process of transition from a healthy condition into ill condition. The transition process started with cyclic lose response which influence type 2 DM patient to self control and make a right decision-making to self care. Self-control would make type 2 DM patients able to adapt and engage with new experiences that become a new habit for type 2 DM patients and will facilitate type 2 DM patients in adapting to the internal and external environment and make type 2 DM patients have a positive hope in their life. Discuss and conclusion: finding in this study would hopefully be beneficial for professional health staff to make assessment about PWB in type 2 DM patients, nurse hopefully can assist patients in transition with the condition of type 2 DM. Need further research about the relation between self acceptance and self control, activation process till engagement to new habit in type 2 DM patients, perceived support to PWB in type 2 DM patient DM.Keywords: psychological well being, type 2 Diabetes mellitus, qualitative

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