scholarly journals Estimation of bone turnover evaluated by 47Ca-kinetics. Efficiency of serum bone gamma-carboxyglutamic acid-containing protein, serum alkaline phosphatase, and urinary hydroxyproline excretion.

1985 ◽  
Vol 76 (6) ◽  
pp. 2254-2258 ◽  
Author(s):  
P Charles ◽  
J W Poser ◽  
L Mosekilde ◽  
F T Jensen
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Serum Alkaline Phosphatase ◽  
Urinary Hydroxyproline ◽  
Carboxyglutamic Acid ◽  
Hydroxyproline Excretion ◽  
Protein Serum

Skeletal Blood Flow in Paget's Disease of Bone and its Response to Calcitonin Therapy

1978 ◽  
Vol 54 (1) ◽  
pp. 69-74 ◽  
Author(s):  
R. Wootton ◽  
J. Reeve ◽  
E. Spellacy ◽  
M. Tellez-Yudilevich
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Flow ◽  
Serum Alkaline Phosphatase ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Short Term ◽  
Urinary Hydroxyproline ◽  
Rapid Fall ◽  
Hydroxyproline Excretion

1. Blood flow to the skeleton was measured by the 18F clearance method of Wootton, Reeve & Veall (1976) in 24 patients with untreated Paget's disease. In every patient but one, resting skeletal blood flow was increased. There was a significant positive correlation between skeletal blood flow and serum alkaline phosphatase and between skeletal blood flow and urinary total hydroxyproline excretion. 2. Fourteen patients were re-studied after they had received short-term (7 days or less) or long-term (7 weeks or more) calcitonin. Skeletal blood flow, alkaline phosphatase and urinary hydroxyproline excretion fell towards normal in every case. There was some evidence from the short-term studies that calcitonin produced a more rapid fall in skeletal blood flow than in alkaline phosphatase. 3. Glomerular filtration rate appeared to increase transiently in response to calcitonin.

Serum alkaline phosphatase and urinary hydroxyproline values in children receiving phenobarbital with and without vitamin D

1975 ◽  
Vol 87 (2) ◽  
pp. 291-296 ◽  
Author(s):  
Dimitrios Liakakos ◽  
Zeta Papadopoulos ◽  
Paul Vlachos ◽  
Ecaterini Boviatsi ◽  
Dionissios D. Varonos
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Urinary Hydroxyproline

Comparison between CEA, TPA, CA 15/3 and Hydroxyproline, Alkaline Phosphatase, Whole Body Retention of 99mTc MDP in the follow-up of Bone Metastases in Breast Cancer

1990 ◽  
Vol 5 (2) ◽  
pp. 65-72 ◽  
Author(s):  
G. Francini ◽  
M. Montagnani ◽  
R. Petrioli ◽  
P. Paffetti ◽  
S. Marsili ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alkaline Phosphatase ◽  
Bone Metastases ◽  
Serum Alkaline Phosphatase ◽  
Whole Body ◽  
Lower Sensitivity ◽  
Osteoblastic Activity ◽  
Body Retention ◽  
Hydroxyproline Excretion

The development of bone metastases in cancer can be monitored easily using three markers: 24 h urinary hydroxyproline excretion (HOP) (an index of osteoclastic activity), serum alkaline phosphatase (Alk.Ph.) (an index of osteoblastic activity) and 24 h whole body retention of 99mTc-methylene diphosphonate (WBR%) (an index of bone turnover). To evaluate the effectiveness of this group of bone tumor markers in breast cancer we compared it with the following group of three markers which are commonly used in the monitoring of breast cancer and in the follow-up of advanced disease with or without bone metastases: carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and breast carcinoma antigen (CA 15/3). In 48 patients with bone metastases CEA, TPA and CA 15/3 were shown to be sensitive (79%, 85%, 90% respectively), while HOP, Alk.Ph. and WBR%, which are commonly accepted as reliable markers of bone activity, showed a lower sensitivity (67%, 46%, 75% respectively). These results may be explained by the lack of osteoclastic or osteoblastic (or both) activity at the time of diagnosis. This explanation is supported by the fact that the bone markers HOP, Alk.Ph. and WBR% were found to be more sensitive than the others in the subsequent follow-up study. We conclude that in our study, CEA, TPA and CA 15/3 are at first more sensitive than Alk. Ph., HOP and WBR% but during the follow-up Alk.Ph., HOP and WBR% are possibly both more specific and more sensitive

TOTAL URINARY HYDROXYPROLINE EXCRETION BEFORE AND AFTER HYPOPHYSECTOMY IN PATIENTS WITH BONE METASTASES FROM BREAST CARCINOMA

1968 ◽  
Vol 59 (3) ◽  
pp. 353-361 ◽  
Author(s):  
Jørn Ditzel ◽  
Robert Jordal ◽  
Niels Riskær
Keyword(s):  
Breast Cancer ◽  
Urinary Excretion ◽  
Bone Metastases ◽  
Healthy Subjects ◽  
Serum Alkaline Phosphatase ◽  
Bone Matrix ◽  
Urinary Hydroxyproline ◽  
Before And After ◽  
The Mean ◽  
Hydroxyproline Excretion

ABSTRACT Recent investigations indicate that the urinary excretion of total hydroxyproline is a measure of the metabolism of collagen, particularly the bone matrix. The total hydroxyproline excretion has been determined in 28 women with bone metastases from breast cancer, and in 12 healthy volunteers. In 22 of the 28 cases with bone metastases the urinary excretion of hydroxyproline was measured shortly before and repeated shortly after hypophysectomy. In addition, the measurements were repeated 3 to 12 months after hypophysectomy in 8 of the patients. The mean excretion of hydroxyproline was significantly higher in patients with bone metastases from breast cancer (52.9 mg/24 h) than in healthy subjects (22.1 mg/24 h). A correlation was found between the urinary excretion of hydroxyproline and serum alkaline phosphatase levels. The mean excretion of total hydroxyproline was 51.0 mg/24 h before hypophysectomy and 63.8 mg/24 h after hypophysectomy. This difference is not statistically significant. Determinations of urinary hydroxyproline excretion in patients with breast cancer has not been found of great value in the assessment of the clinical condition of these patients.

scholarly journals Juvenile Paget’s disease: Report of a family with a novel missense mutation and unique radiological manifestations in a heterozygote

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
O Khalifa ◽  
K Ramzan ◽  
A S Moustafa ◽  
K AlMane ◽  
M Abdelfattah ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Skeletal Dysplasia ◽  
Serum Alkaline Phosphatase ◽  
Phenotypic Variability ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Homozygous Mutation ◽  
Markers Of Bone Turnover ◽  
Juvenile Paget’S Disease

Abstract Juvenile Paget’s disease (JPD) is a rare, generalized skeletal disorder characterized by markedly increased bone turnover secondary to enhanced osteoclastic activity. The patients with JPD develop progressive, widespread skeletal involvement and non-skeletal manifestations. Objectives To identify the characteristic molecular, biochemical, radiological, and audiological findings in three siblings with JPD associated with intrafamilial phenotypic variability. Patients and Methods A Saudi family with 3 affected siblings was recruited. Biochemical measurement of serum alkaline phosphatase and markers of bone turnover were performed. Genetic testing and sequencing of a panel of 22 known genes for skeletal dysplasia with increase bone density were performed by next generation sequencing (NGS). Radiological and audiological assessment were also performed. Results Patients showed marked elevation of serum alkaline phosphatase and markers of bone turnover. A novel homozygous mutation c.433T>G (p.Cys145Gly) in exon 3 of TNFRSF11B gene was identified in the 3 affected siblings. Both parents were heterozygous for the mutation. The heterozygote father had thickening of calvarium, a radiological manifestation of JPD. The eldest child (index case) had a unique striking distortion of the skull bones as evidenced by 3-D computed tomography of skull. He had also bilateral inner ear structural deformity and severe sensorineural hearing loss. Conclusions: JPD is a rare disorder that can be highly overlooked due to phenotypic overlap with other disorders of skeletal dysplasia. Mutations affecting cysteine residues result in the most severe JPD phenotypes. NGS is useful for early diagnosis of JPD, a prerequisite for successful treatment strategy.

Elevation of serum alkaline phosphatase (ALP) level in postmenopausal women is caused by high bone turnover

2014 ◽  
Vol 27 (4) ◽  
pp. 413-418 ◽  
Author(s):  
Keijiro Mukaiyama ◽  
Mikio Kamimura ◽  
Shigeharu Uchiyama ◽  
Shota Ikegami ◽  
Yukio Nakamura ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Serum Alkaline Phosphatase ◽  
High Bone Turnover ◽  
High Bone

Correlation of urinary hydroxyproline, serum alkaline phosphatase and skeletal calcium turnover

Metabolism ◽  
1964 ◽  
Vol 13 (3) ◽  
pp. 272-284 ◽  
Author(s):  
LeRoy Klein ◽  
Frederic W. Lafferty ◽  
Olof H. Pearson ◽  
Paul H. Curtiss
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Urinary Hydroxyproline ◽  
Skeletal Calcium

Augmanting buffalo reproduction in tribal areas of Panchmahal district (Gujarat) through appropriate mineral mixture supplementation

2015 ◽  
Author(s):  
J. B. Butani ◽  
S. Parnerkar ◽  
D. C. Patel
Keyword(s):  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Average Intake ◽  
Mineral Mixture ◽  
Calcium Phosphorus ◽  
On Farm ◽  
Tribal Areas ◽  
Mineral Mixtures ◽  
Protein Serum ◽  
Repeat Breeder

An on-farm trial for 90 days was conducted using 20 anoestrus and 20 repeat breeder buffaloes to evaluate the effect of supplementing appropriate mineral mixtures (AMMs) on their return to heat. Anoestrus and repeat breeder buffaloes were randomly allotted to 2 treatments i.e. T1 (Ionic mineral mixture) and T2 (T1 + 25% extra zinc in chelate form). Average DMI, DCPI and TDNI in anoestrus and repeat breeder buffaloes calculated as per information collected from farmers were comparable among treatments. Average intake of calcium, phosphorus and copper was higher than the requirements in anoestrus and repeat breeder buffaloes. However, Zn intake was lower by about 65% of the requirement in all treatments. Blood glucose ranged from 57.4 to 62.4 mg/dl in T1 and T2 groups of anoestrus and repeat breeder buffaloes. On supplementing the T2 mineral mixture, the level of total protein, serum albumin, globulin, triglycerides and cholesterol increased (P<0.01), whereas, level of BUN and creatinine decreased significantly in both groups of anestrous and repeat breeder buffaloes than in buffaloes supplemented with T1. Activities of serum alkaline phosphatase, alanine aminotransferases and aspartate aminotransferases increased significantly (P<0.01) on T2 supplementation. Number of days taken for return to heat of anoestrous and repeat breeder buffaloes as well as cost of feeding reduced upon supplementation with T2 from T1 mineral mixture.

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