The Activity of the Bone Isoenzyme of Serum Alkaline Phosphatase and Urinary Hydroxyproline Excretion in Premenopausal and Postmenopausal Women with Primary Hyperparathyroidism

2009 ◽  
Vol 83 (03) ◽  
pp. 315-319
Author(s):  
P. Broulik ◽  
J. Štěpán ◽  
V. Pacovský
Keyword(s):  
Alkaline Phosphatase ◽  
Primary Hyperparathyroidism ◽  
Postmenopausal Women ◽  
Serum Alkaline Phosphatase ◽  
Urinary Hydroxyproline ◽  
Hydroxyproline Excretion

Skeletal Blood Flow in Paget's Disease of Bone and its Response to Calcitonin Therapy

1978 ◽  
Vol 54 (1) ◽  
pp. 69-74 ◽  
Author(s):  
R. Wootton ◽  
J. Reeve ◽  
E. Spellacy ◽  
M. Tellez-Yudilevich
Keyword(s):  
Alkaline Phosphatase ◽  
Blood Flow ◽  
Serum Alkaline Phosphatase ◽  
Paget’S Disease ◽  
Paget's Disease ◽  
Short Term ◽  
Urinary Hydroxyproline ◽  
Rapid Fall ◽  
Hydroxyproline Excretion

1. Blood flow to the skeleton was measured by the 18F clearance method of Wootton, Reeve & Veall (1976) in 24 patients with untreated Paget's disease. In every patient but one, resting skeletal blood flow was increased. There was a significant positive correlation between skeletal blood flow and serum alkaline phosphatase and between skeletal blood flow and urinary total hydroxyproline excretion. 2. Fourteen patients were re-studied after they had received short-term (7 days or less) or long-term (7 weeks or more) calcitonin. Skeletal blood flow, alkaline phosphatase and urinary hydroxyproline excretion fell towards normal in every case. There was some evidence from the short-term studies that calcitonin produced a more rapid fall in skeletal blood flow than in alkaline phosphatase. 3. Glomerular filtration rate appeared to increase transiently in response to calcitonin.

Serum alkaline phosphatase and urinary hydroxyproline values in children receiving phenobarbital with and without vitamin D

1975 ◽  
Vol 87 (2) ◽  
pp. 291-296 ◽  
Author(s):  
Dimitrios Liakakos ◽  
Zeta Papadopoulos ◽  
Paul Vlachos ◽  
Ecaterini Boviatsi ◽  
Dionissios D. Varonos
Keyword(s):  
Vitamin D ◽  
Alkaline Phosphatase ◽  
Serum Alkaline Phosphatase ◽  
Urinary Hydroxyproline

Comparison between CEA, TPA, CA 15/3 and Hydroxyproline, Alkaline Phosphatase, Whole Body Retention of 99mTc MDP in the follow-up of Bone Metastases in Breast Cancer

1990 ◽  
Vol 5 (2) ◽  
pp. 65-72 ◽  
Author(s):  
G. Francini ◽  
M. Montagnani ◽  
R. Petrioli ◽  
P. Paffetti ◽  
S. Marsili ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Alkaline Phosphatase ◽  
Bone Metastases ◽  
Serum Alkaline Phosphatase ◽  
Whole Body ◽  
Lower Sensitivity ◽  
Osteoblastic Activity ◽  
Body Retention ◽  
Hydroxyproline Excretion

The development of bone metastases in cancer can be monitored easily using three markers: 24 h urinary hydroxyproline excretion (HOP) (an index of osteoclastic activity), serum alkaline phosphatase (Alk.Ph.) (an index of osteoblastic activity) and 24 h whole body retention of 99mTc-methylene diphosphonate (WBR%) (an index of bone turnover). To evaluate the effectiveness of this group of bone tumor markers in breast cancer we compared it with the following group of three markers which are commonly used in the monitoring of breast cancer and in the follow-up of advanced disease with or without bone metastases: carcinoembryonic antigen (CEA), tissue polypeptide antigen (TPA) and breast carcinoma antigen (CA 15/3). In 48 patients with bone metastases CEA, TPA and CA 15/3 were shown to be sensitive (79%, 85%, 90% respectively), while HOP, Alk.Ph. and WBR%, which are commonly accepted as reliable markers of bone activity, showed a lower sensitivity (67%, 46%, 75% respectively). These results may be explained by the lack of osteoclastic or osteoblastic (or both) activity at the time of diagnosis. This explanation is supported by the fact that the bone markers HOP, Alk.Ph. and WBR% were found to be more sensitive than the others in the subsequent follow-up study. We conclude that in our study, CEA, TPA and CA 15/3 are at first more sensitive than Alk. Ph., HOP and WBR% but during the follow-up Alk.Ph., HOP and WBR% are possibly both more specific and more sensitive

Changes in Serum Calcium, Albumin and Alkaline Phosphatase Levels of Postmenopausal Women

2019 ◽  
Vol 8 (2) ◽  
pp. 30-35
Author(s):  
Kamana Rani Saha ◽  
Susmita Das ◽  
Shahidul Islam ◽  
AHM Hasan ◽  
Rafika Afrose ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Postmenopausal Women ◽  
Serum Calcium ◽  
Serum Alkaline Phosphatase ◽  
Colorimetric Method ◽  
Medical College Hospital ◽  
Reproductive Age ◽  
College Hospital ◽  
Medical College ◽  
Increased Risk

A case-control cross-sectional study was carried out to observe the changes in serum calcium, albumin and alkaline phosphatase levels of postmenopausal women compared to their premenopausal counterparts. This is to enable us ascertain the relative risk of developing osteoporosis in postmenopausal women in Bangladesh. One hundred and eighteen (118) apparently healthy females (59 premenopausal=control and 59 postmenopausal=case) were selected for the study. The study was carried out in the Department of Biochemistry, Mymensingh Medical College in cooperation with the Department of Gynecology, Mymensingh Medical College Hospital and Community Based Medical College Hospital Bangladesh during the period from January to December 2009. Data were collected through clinical evaluation from pre-selected questionnaires. Fasting venous blood samples were taken for laboratory investigations. Serum calcium and albumin was determined using colorimetric method and enzymatic end point method was used to determine serum alkaline phosphatase levels. Statistical significance of difference between two groups were evaluated by using Student's unpaired 't' test with the help of SPSS software package. The results showed statistically significant decrease in serum calcium and albumin (p<0.01) of menopausal women compared to reproductive age group. The postmenopausal women had significantly higher (p<0.01) concentrations of serum alkaline phosphatase than the premenopausal women with regular menstruation. Therefore, it can be concluded that menopause leads to the increased risk of osteoporosis by decreasing serum calcium and albumin and by increasing alkaline phosphatase levels. The decreased serum calcium and increased alkaline phosphatase levels indicate that menopause is an independent risk factor for developing osteoporosis in women of Bangladesh. CBMJ 2019 July: Vol. 08 No. 02 P: 30-35

Bone mass as referent for urinary hydroxyproline excretion: Age and sex-related changes in 125 normals and in primary hyperparathyroidism

1984 ◽  
Vol 36 (1) ◽  
pp. 639-644 ◽  
Author(s):  
Lars Hyldstrup ◽  
Peter McNair ◽  
Grethe Finn Jensen ◽  
Henrik Rist Nielsen ◽  
Ib Transbøl
Keyword(s):  
Primary Hyperparathyroidism ◽  
Bone Mass ◽  
Urinary Hydroxyproline ◽  
Hydroxyproline Excretion ◽  
Age And Sex

TOTAL URINARY HYDROXYPROLINE EXCRETION BEFORE AND AFTER HYPOPHYSECTOMY IN PATIENTS WITH BONE METASTASES FROM BREAST CARCINOMA

1968 ◽  
Vol 59 (3) ◽  
pp. 353-361 ◽  
Author(s):  
Jørn Ditzel ◽  
Robert Jordal ◽  
Niels Riskær
Keyword(s):  
Breast Cancer ◽  
Urinary Excretion ◽  
Bone Metastases ◽  
Healthy Subjects ◽  
Serum Alkaline Phosphatase ◽  
Bone Matrix ◽  
Urinary Hydroxyproline ◽  
Before And After ◽  
The Mean ◽  
Hydroxyproline Excretion

ABSTRACT Recent investigations indicate that the urinary excretion of total hydroxyproline is a measure of the metabolism of collagen, particularly the bone matrix. The total hydroxyproline excretion has been determined in 28 women with bone metastases from breast cancer, and in 12 healthy volunteers. In 22 of the 28 cases with bone metastases the urinary excretion of hydroxyproline was measured shortly before and repeated shortly after hypophysectomy. In addition, the measurements were repeated 3 to 12 months after hypophysectomy in 8 of the patients. The mean excretion of hydroxyproline was significantly higher in patients with bone metastases from breast cancer (52.9 mg/24 h) than in healthy subjects (22.1 mg/24 h). A correlation was found between the urinary excretion of hydroxyproline and serum alkaline phosphatase levels. The mean excretion of total hydroxyproline was 51.0 mg/24 h before hypophysectomy and 63.8 mg/24 h after hypophysectomy. This difference is not statistically significant. Determinations of urinary hydroxyproline excretion in patients with breast cancer has not been found of great value in the assessment of the clinical condition of these patients.

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