Elevation of serum alkaline phosphatase (ALP) level in postmenopausal women is caused by high bone turnover

2014 ◽  
Vol 27 (4) ◽  
pp. 413-418 ◽  
Author(s):  
Keijiro Mukaiyama ◽  
Mikio Kamimura ◽  
Shigeharu Uchiyama ◽  
Shota Ikegami ◽  
Yukio Nakamura ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Serum Alkaline Phosphatase ◽  
High Bone Turnover ◽  
High Bone

scholarly journals Clinical Prediction of High-Turnover Bone Disease After Kidney Transplantation

2021 ◽  
Author(s):  
Satu M. Keronen ◽  
Leena A. L. Martola ◽  
Patrik Finne ◽  
Inari S. Burton ◽  
Xiaoyu F. Tong ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Kidney Transplant ◽  
Bone Biopsy ◽  
Transplant Recipients ◽  
Kidney Transplant Recipients ◽  
Bone Biomarkers ◽  
High Turnover ◽  
High Bone Turnover ◽  
High Bone

AbstractBone histomorphometric analysis is the most accurate method for the evaluation of bone turnover, but non-invasive tools are also required. We studied whether bone biomarkers can predict high bone turnover determined by bone histomorphometry after kidney transplantation. We retrospectively evaluated the results of bone biopsy specimens obtained from kidney transplant recipients due to the clinical suspicion of high bone turnover between 2000 and 2015. Bone biomarkers were acquired concurrently. Of 813 kidney transplant recipients, 154 (19%) biopsies were taken at a median of 28 (interquartile range, 18–70) months after engraftment. Of 114 patients included in the statistical analysis, 80 (70%) presented with high bone turnover. Normal or low bone turnover was detected in 34 patients (30%). For discriminating high bone turnover from non-high, alkaline phosphatase, parathyroid hormone, and ionized calcium had the areas under the receiver operating characteristic curve (AUCs) of 0.704, 0.661, and 0.619, respectively. The combination of these markers performed better with an AUC of 0.775. The positive predictive value for high turnover at a predicted probability cutoff of 90% was 95% while the negative predictive value was 35%. This study concurs with previous observations that hyperparathyroidism with or without hypercalcemia does not necessarily imply high bone turnover in kidney transplant recipients. The prediction of high bone turnover can be improved by considering alkaline phosphatase levels, as presented in the logistic regression model. If bone biopsy is not readily available, this model may serve as clinically available tool in recognizing high turnover after engraftment.

scholarly journals Serum Biomarker Profile Associated With High Bone Turnover and BMD in Postmenopausal Women

2008 ◽  
Vol 23 (7) ◽  
pp. 1106-1117 ◽  
Author(s):  
Sudeepa Bhattacharyya ◽  
Eric R Siegel ◽  
Sara J Achenbach ◽  
Sundeep Khosla ◽  
Larry J Suva
Keyword(s):  
Bone Turnover ◽  
Postmenopausal Women ◽  
Serum Biomarker ◽  
High Bone Turnover ◽  
High Bone

High Bone Turnover is Associated with Low Bone Mass and Spinal Fracture in Postmenopausal Women

1997 ◽  
Vol 60 (3) ◽  
pp. 255-260 ◽  
Author(s):  
P. Ravn ◽  
M. Rix ◽  
H. Andreassen ◽  
B. Clemmesen ◽  
M. Bidstrup ◽  
...  
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Spinal Fracture ◽  
Low Bone Mass ◽  
High Bone Turnover ◽  
High Bone

scholarly journals KOSTNYY METABOLIZM I POTERYa KOSTNOY TKANI V OTDALENNYE SROKI POSLE ALLOTRANSPLANTATsII TRUPNOY POChKI (ATP) (ODNOMOMENTNOE ISSLEDOVANIE)

2005 ◽  
Vol 8 (2) ◽  
pp. 30-33
Author(s):  
I P ERMAKOVA ◽  
I A PRONChENKO ◽  
V P BUZULINA ◽  
N A TOMILINA ◽  
R N VEDERNIKOVA ◽  
...  
Keyword(s):  
Renal Failure ◽  
Alkaline Phosphatase ◽  
Bone Turnover ◽  
Mineral Content ◽  
Bone Alkaline Phosphatase ◽  
Calcium Excretion ◽  
High Bone Turnover ◽  
High Bone ◽  
Turnover Markers ◽  
High Degree

Bone turnover markers [osteocalcin (OC), carboxyterminal procollagen I propeptide (PICP), bone alkaline phosphatase (bALP), deoxypyridinoline (DPD), β -crosslaps (CTX), bone acid phosphatase (bACP), parathyroid hormone (PTH)], day calcium excretion (uCaV) and lumbar and hip bone mineral content (BMC) were determined in 195 patients [78 women and 74 men with intact renal function as well as 11 women and 31 men with renal failure (RF)] 40±33 months following KT. KT recipients received triple immunosuppressive therapy (CysA, prednisolone and azathioprine). All groups showed bone remodeling dissociation namely bone resorption increase (high CTX, DPD, bACP) and bone formation retard (mild enhanced level OC, normal or low bALP) in association with high PTH, decreased uCaV and BMC levels. High bone turnover and low uCaV were much more high degree in RF. Vertebral and femur BMC decrease was mild (osteopenia) and only men with RF revealed peripheral osteoporosis. Hyperparathyroidism was associated with decreased transplant function and was main predictor of high bone turnover and bone loss after KT.

High bone turnover is associated with low bone mass in both pre- and postmenopausal women

Bone ◽  
1996 ◽  
Vol 19 (3) ◽  
pp. 291-298 ◽  
Author(s):  
P. Ravn ◽  
C. Fledelius ◽  
C. Rosenquist ◽  
K. Overgaard ◽  
C. Christiansen
Keyword(s):  
Bone Mass ◽  
Bone Turnover ◽  
Postmenopausal Women ◽  
Low Bone Mass ◽  
High Bone Turnover ◽  
High Bone

High bone turnover markers and disturbances of bone mineral density in children with hypophosphataemic rickets

2017 ◽  
Author(s):  
Agnieszka Rusinska ◽  
Izabela Michalus ◽  
Izabela Woch ◽  
Paulina Adamiecka ◽  
Danuta Chlebna-Sokol
Keyword(s):  
Bone Mineral Density ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Bone Turnover Markers ◽  
Mineral Density ◽  
Hypophosphataemic Rickets ◽  
High Bone Turnover ◽  
High Bone ◽  
Turnover Markers

scholarly journals The Presence of Thyroid-Stimulation Blocking Antibody Prevents High Bone Turnover in Untreated Premenopausal Patients with Graves’ Disease

PLoS ONE ◽  
2015 ◽  
Vol 10 (12) ◽  
pp. e0144599 ◽  
Author(s):  
Sun Wook Cho ◽  
Jae Hyun Bae ◽  
Gyeong Woon Noh ◽  
Ye An Kim ◽  
Min Kyong Moon ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Graves Disease ◽  
Blocking Antibody ◽  
High Bone Turnover ◽  
High Bone ◽  
Premenopausal Patients

scholarly journals Raloxifene Has No Efficacy in Reducing the High Bone Turnover and the Risk of Spontaneous Vertebral Fractures after Denosumab Discontinuation

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Elena Gonzalez-Rodriguez ◽  
Delphine Stoll ◽  
Olivier Lamy
Keyword(s):  
Bone Loss ◽  
Bone Turnover ◽  
Aromatase Inhibitors ◽  
Vertebral Fractures ◽  
Bone Markers ◽  
Rebound Effect ◽  
High Bone Turnover ◽  
Antiresorptive Agent ◽  
High Bone

At denosumab discontinuation, an antiresorptive agent is prescribed to reduce the high bone turnover, the rapid bone loss, and the risk of spontaneous vertebral fractures. We report the case of a woman treated with aromatase inhibitors and denosumab for 5 years. Raloxifene was then prescribed to prevent the rebound effect. Raloxifene was ineffective to reduce the high bone turnover and to avoid spontaneous clinical vertebral fractures. We believe that among the antiresorptive treatments, the most powerful bisphosphonates should be favored, and their administration adapted according to the serial follow-up of bone markers.

scholarly journals High bone turnover status as a risk factor in symptomatic hypocalcemia following denosumab treatment in a male patient with osteoporosis

2018 ◽  
Vol Volume 13 ◽  
pp. 1929-1934 ◽  
Author(s):  
Koji Ishikawa ◽  
Takashi Nagai ◽  
Koki Tsuchiya ◽  
Yusuke Oshita ◽  
Takuma Kuroda ◽  
...  
Keyword(s):  
Risk Factor ◽  
Bone Turnover ◽  
Male Patient ◽  
High Bone Turnover ◽  
Symptomatic Hypocalcemia ◽  
High Bone ◽  
Denosumab Treatment
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