Supermassive Transfusion: A 15-Year Single Center Experience and Outcomes

2018 ◽  
Vol 84 (10) ◽  
pp. 1617-1621 ◽  
Author(s):  
Alison J. Yu ◽  
Kenji Inaba ◽  
Subarna Biswas ◽  
Luis Alejandro De Leon ◽  
Monica Wong ◽  
...  
Keyword(s):  
Glasgow Coma Scale ◽  
Injury Severity Score ◽  
Severity Score ◽  
Injury Severity ◽  
Characteristic Curve ◽  
Univariate Analysis ◽  
Female Gender ◽  
Trauma Patients ◽  
Coma Scale ◽  
Single Center Experience

The objective of this study was to determine the survival outcome associated with large-volume blood transfusion after trauma. This was a retrospective study at a Level I trauma center from January 2000 to December 2014 that included trauma patients who received ≥25 units packed red blood cell (pRBC) within the first 24 hours of hospital admission. Univariate and multivariable logistic regressions identified risk factors for mortality. Receiver operating characteristic curve analysis evaluated the ability of pRBC volume to predict mortality. Among 74,065 adults (‡18 years old), 178 patients (0.24%) received ≥25 units of pRBC in the first 24 hours, of which 142 (79.8%) received 25 to 49 units, 28 (15.7%) received 50 to 74 units, and 8 (4.5%) received ≥75 units. Overall, 92.2 per cent were male, mean age 33.9 (614.0), mean Injury Severity Score 28.9 (614.3), and median Glasgow Coma Scale score 12 (3–15). The overall mortality was 65.2 per cent and 64.1 per cent for those receiving 25 to 49 units, 64.3 per cent for 50 to 74 units, and 87.5 per cent for ≥75 units. In univariate analysis, female gender was associated with lower mortality [odds ratio (OR) 0.24, P = 0.025]. Decreasing Glasgow Coma Scale (OR 0.82, P < 0.001), increasing Injury Severity Score (OR 1.07, P < 0.001), and thoracotomy (OR 3.91, P < 0.001) were associated with higher mortality. There was no transfusion cutoff that was significantly associated with higher mortality.

Activation of Massive Transfusion for Elderly Trauma Patients

2015 ◽  
Vol 81 (10) ◽  
pp. 945-949 ◽  
Author(s):  
Jason S. Murry ◽  
Andrea A. Zaw ◽  
David M. Hoang ◽  
Devorah Mehrzadi ◽  
Danielle Tran ◽  
...  
Keyword(s):  
Length Of Stay ◽  
Glasgow Coma Scale ◽  
Injury Severity Score ◽  
Severity Score ◽  
Injury Severity ◽  
Massive Transfusion ◽  
Hospital Length Of Stay ◽  
Trauma Patients ◽  
Coma Scale ◽  
Elderly Trauma Patients

Massive transfusion protocol (MTP) is used to resuscitate patients in hemorrhagic shock. Our goal was to review MTP use in the elderly. All trauma patients who required activation of MTP at an urban Level I trauma center from January 1, 2011 to December 31, 2013 were reviewed retrospectively. Elderly was defined as age ≥ 60 years. Sixty-six patients had MTP activated: 52 non-elderly (NE) and 14 elderly (E). There were no statistically significant differences between the two cohorts for gender, injury severity score, head abbreviated injury scale, emergency department Glasgow Coma Scale, initial hematocrit, intensive care unit length of stay, or hospital length of stay. Mean age for NE was 35 years and 73 years for E ( P < 0.01). Less than half (43%) of E patients with activation of MTP received 10 or more units of blood products compared with 69 per cent of the NE ( P = 0.07). Mortality rates were similar in the NE and the E (53% vs 50%, P = 0.80). After multivariate analysis with Glasgow Coma Scale, injury severity score, and blunt versus penetrating trauma, elderly age was not a predictor of mortality after MTP ( P = 0.35). When MTP is activated, survival to discharge in elderly trauma patients is comparable to younger patients.

Venous Thromboembolism in Trauma Patients

2007 ◽  
Vol 73 (11) ◽  
pp. 1173-1180 ◽  
Author(s):  
Om P. Sharma ◽  
Michael F. Oswanski ◽  
Rusin J. Joseph ◽  
Peter Tonui ◽  
Libby Westrick Pa-C ◽  
...  
Keyword(s):  
Risk Factor ◽  
Venous Thromboembolism ◽  
Injury Severity Score ◽  
Severity Score ◽  
Injury Severity ◽  
Univariate Analysis ◽  
Trauma Patients ◽  
Vein Thrombosis ◽  
Cord Injury ◽  
Deep Vein

Serial venous duplex scans (VDS) were done in 507 trauma patients with at least one risk factor (RF) for venous thromboembolism (VTE) during a 2-year study period. Deep vein thrombosis (DVT) was detected in 31 (6.1%) patients. This incidence was 3.1 per cent in low (1–2 RFs), 3.4 per cent in moderate (3–5 RFs), and 7.7 per cent in high (≥6 RFs) VTE scores ( P = 0.172). Incidence was statistically different (3% vs 7.2%, P = 0.048) on reanalyzing patients in two risk categories, low-risk (1–4 RFs) and high-risk (≥5 RFs). Only 4 of 16 RFs had statistically higher incidence of DVT in patients with or without RFs: previous VTE (27.3% vs 5.6%, odds ratio (OR) 6.628, P = 0.024), spinal cord injury (22.6% vs 5%, OR 5.493, P = 0.001), pelvic fractures (11.4% vs 5.1%, OR 2.373, P = 0.042), and head injury with a greater than two Abbreviated Injury Score (10.5% vs 4.2%, OR 2.639, P = 0.014). On reanalyzing patients with ≥5 RFs vs <5RFs, obesity (14.3 vs 6.1%, P = 0.007), malignancy (5.6% vs 0.6%, P = 0.006), coagulopathy (10.8% vs 1.8%, P = 0.000), and previous VTE (3.2% vs 0%, P = 0.019) were significant on univariate analysis. Patients with DVT had 3.70 ± 1.75 RFs and a 9.61 ± 4.93 VTE score, whereas, patients without DVT had 2.66 ± 1.50 RFs and a 6.83 ± 3.91 VTE score ( P = 0.000). DVTs had a direct positive relationship with higher VTE scores, length of stay, and number of VDS (>1 r, P ≤ 0.001). Increasing age was a weak risk factor (0.03 r, P = 0.5). First two VDS diagnosed 77 per cent of DVTs. Patients with injury severity score of ≥15 and 25 had higher DVTs compared with the ones with lower injury severity score levels ( P ≤ 0.05). Pulmonary embolism was silent in 63 per cent and DVTs were asymptomatic in 68 per cent.

Penetrating brain injury: a case of survival following blast fragmentation injuries to the head

2013 ◽  
Vol 99 (2) ◽  
pp. 55-56
Author(s):  
J McKinlay ◽  
JE Smith
Keyword(s):  
Brain Injury ◽  
Glasgow Coma Scale ◽  
Injury Severity Score ◽  
Severity Score ◽  
Injury Severity ◽  
Head Injuries ◽  
Good Recovery ◽  
Coma Scale ◽  
Blast Fragmentation ◽  
Serious Injuries

AbstractWe present a case of penetrating head injuries caused by blast fragmentation, along with other serious injuries (including to the arms, face and neck), where a good recovery was made despite an Injury Severity Score (ISS) of 75. We suggest that survival and outcome are reliant on several factors and cannot be predicted from ISS, velocity of penetrating injury or presenting Glasgow Coma Scale (GCS) alone.

scholarly journals Injuries type and its relation with Glasgow Coma Scale, injury severity score and blood transfusion in road traffic accident Victims.

2018 ◽  
Vol 23 (2) ◽  
pp. 148-159
Author(s):  
Abdullah Alqarni Abdulaziz ◽  
Ghanem Alanazi Radhi ◽  
Anthony Morgan ◽  
Ahmed Saud Alharbi ◽  
Faisal Fahad Aljuaid ◽  
...  
Keyword(s):  
Blood Transfusion ◽  
Glasgow Coma Scale ◽  
Injury Severity Score ◽  
Severity Score ◽  
Road Traffic Accident ◽  
Traffic Accident ◽  
Injury Severity ◽  
Road Traffic ◽  
Coma Scale

scholarly journals Evaluation of complete profile and outcome of gunshot injuries in tertiary care centre

2019 ◽  
Vol 6 (2) ◽  
pp. 397
Author(s):  
Fazle Rab Malik ◽  
Santosh Kumar Singh ◽  
Shivam Madeshiya ◽  
Roshni Khan ◽  
Nandan Rai
Keyword(s):  
Glasgow Coma Scale ◽  
Injury Severity Score ◽  
Severity Score ◽  
Injury Severity ◽  
Tertiary Care ◽  
Gunshot Injury ◽  
Coma Scale ◽  
Gunshot Injuries ◽  
Revised Trauma Score ◽  
Trauma Score

Background: Gunshot injuries are range from minor superficial pellet injuries to devastating soft tissue and visceral injuries. The objective of study was to evaluate complete profile and outcome of gunshot injuries in tertiary care centre.Methods: This study was a prospective study. All gunshot injury patients who admitted in Department of Surgery, Moti Lal Nehru Medical College, Allahabad were included in study.Results: Result were analysed in terms of age, sex, rural-urban and religion wise distribution, etiology of injury, arms and ammunition, time elapsed in first aid, site of injury, associated injury, organ involved, Glasgow coma scale, injury severity score, revised trauma score, various blood and radiological investigations, treatment and complications.Conclusions: Gunshot injury was common in male patients, age group 21-30years, Hindu community and in rural areas. Most patients received injury by shotgun. Assault was most common cause followed by accidental injury. Majority of patients had Glasgow coma scale between 13-15, injury severity score below 20 and revised trauma score more than eight.  Mortality and morbidity were more common in patients with high injury severity score, low revised trauma score and Glasgow coma scale below 8. Abdomen was most common site involved in gunshot injury. Most of the patients were managed conservatively as these patients had external body surface injury. Laparotomy was done for intra-abdominal injury. Wound infection was the most common complication.

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