scholarly journals Potential Role of Cyclosporin a in Corneal Grafting

1981 ◽  
Vol 74 (11) ◽  
pp. 810-813 ◽  
Author(s):  
P A Hunter
Keyword(s):  
Cyclosporin A ◽  
Intramuscular Injection ◽  
Potential Role ◽  
Immunosuppressive Drug ◽  
Corneal Allograft ◽  
Corneal Grafting ◽  
Corneal Transplants ◽  
Series Of Experiments ◽  
Single Set

The immunosuppressive drug cyclosporin A has been shown to be effective in preventing corneal allograft reactions in rabbits when administered by intramuscular injection. However, when used systemically in man, the drug may have potentially serious side effects and a series of experiments has therefore been performed in order to investigate the use of topically applied cyclosporin A in rabbit corneal transplants. Using a single set model of the corneal allograft reaction, two groups of rabbits treated with topically applied cyclosporin A for periods of four and thirteen weeks respectively showed significantly increased graft survival compared with untreated controls (P < 0.001).

scholarly journals Potential role of circular RNA in cyclosporin A‐induced cardiotoxicity in rats

2021 ◽  
Author(s):  
Yanru Zhao ◽  
Yang Li ◽  
Dachuan Fan ◽  
Jinxiao Hou ◽  
Yunpeng Bai ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Potential Role ◽  
Circular Rna

scholarly journals Cyclophilin A regulates A549 cells apoptosis via stabilizing Twist1 protein

2021 ◽  
Author(s):  
Yaru Wu ◽  
Zhenling Ma ◽  
Yanyan Zhang ◽  
Min Zhang ◽  
Wenwen Zhang ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Intracellular Signaling ◽  
A549 Cells ◽  
Cyclophilin A ◽  
Immunosuppressive Drug ◽  
Nuclear Accumulation ◽  
Biological Processes ◽  
Peptide Bonds ◽  
Intracellular Target

Cyclophilin A (CypA) is an essential member of the immunophilin family. As an intracellular target of immunosuppressive drug cyclosporin A (CsA) or a peptidyl-prolyl cis/trans isomerase (PPIase), it catalyzes the cis-trans isomerization of proline amidic peptide bonds, through which, it regulates a variety of biological processes, such as intracellular signaling, transcription, and apoptosis. In this study, we found that intracellular CypA enhanced Twist1 phosphorylation at Ser68 and inhibited apoptosis in A549 cells. Mechanistically, CypA could mediate the phosphorylation of Twist1 at Ser68 via p38 MAPK, which inhibited its ubiquitination-mediated degradation. In addition, CypA increased Twist–p65 interaction and nuclear accumulation, which regulated Twist1-dependent expression of CDH1 and CDH2. Our findings collectively indicated the role of CypA in Twist1-mediated A549 cells apoptosis through stabilizing Twist1 protein.

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

The Effect of Path Length and Display Size on Memory for Spatial Information

2012 ◽  
Vol 59 (3) ◽  
pp. 147-152 ◽  
Author(s):  
Katherine Guérard ◽  
Sébastien Tremblay
Keyword(s):  
Path Length ◽  
Potential Role ◽  
Spatial Information ◽  
Recall Performance ◽  
Minor Role ◽  
Length Effect ◽  
Serial Memory ◽  
Fixed Reference ◽  
A Minor

In serial memory for spatial information, some studies showed that recall performance suffers when the distance between successive locations increases relatively to the size of the display in which they are presented (the path length effect; e.g., Parmentier et al., 2005) but not when distance is increased by enlarging the size of the display (e.g., Smyth & Scholey, 1994). In the present study, we examined the effect of varying the absolute and relative distance between to-be-remembered items on memory for spatial information. We manipulated path length using small (15″) and large (64″) screens within the same design. In two experiments, we showed that distance was disruptive mainly when it is varied relatively to a fixed reference frame, though increasing the size of the display also had a small deleterious effect on recall. The insertion of a retention interval did not influence these effects, suggesting that rehearsal plays a minor role in mediating the effects of distance on serial spatial memory. We discuss the potential role of perceptual organization in light of the pattern of results.

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