scholarly journals The Prognostic Value of Circulating Inflammatory Cell Counts in Sudden Sensorineural Hearing Loss and the Effect of Cardiovascular Risk Factors

2020 ◽  
Vol 99 (7) ◽  
pp. 464-469
Author(s):  
Mehmet Eser Sancaktar ◽  
İbrahim Ağrı ◽  
Ayşe Bel Çeçen ◽  
Gökhan Akgül ◽  
Mehmet Çelebi
Keyword(s):  
Hearing Loss ◽  
Cardiovascular Risk ◽  
Inflammatory Response ◽  
Sensorineural Hearing Loss ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Lymphocyte Ratio ◽  
Group 4 ◽  
Cell Counts ◽  
Group 1

Objectives: Recent studies suggest that elevated neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are poor prognostic factors in sudden sensorineural hearing loss (SSNHL). We aimed to investigate the accuracy of this hypothesis by taking into account the effect of cardiovascular risk (CVR) factors. Methods: Medical records of 122 patients with SSNHL were reviewed retrospectively and grouped into 2 as; patients without CVR (group 1; n = 68) and patients having CVR (group 2; n = 54). Moreover, 60 control cases who did not have SSNHL were also included and grouped into 2 as; group 3 (n = 30) with CVR and group 4 (n = 30) healthy controls without having SSNHL or CVRs. Neutrophil (N), lymphocyte (L), platelet (Plt), NLR, and PLR between the groups and their relationship with the severity of hearing loss, recovery rates, and audiogram configurations were analyzed. Results: The highest N and NLR values were in group 1 and were significantly higher than the values of group 4 ( P < .05, P < .01). There was no significant relationship between the groups in terms of L, Plt, or PLR values. The highest NLR and PLR values were determined in SSNHL patients with mild hearing loss, complete recovery, and up-sloping audiogram configuration ( P > .05). Conclusions: Elevated levels of N and NLR may be considered as strong laboratory findings showing an inflammatory response in the diagnosis of SSNHL, but the presence of CVR factors does not seem to increase the inflammatory response in SSNHL as expected. In patients with SSNHL, NLR and PLR elevation may indicate better prognosis.

scholarly journals The prognostic and predictive value of platelet parameters in diabetic and nondiabetic patients with sudden sensorineural hearing loss

2020 ◽  
Vol 15 (1) ◽  
pp. 884-889
Author(s):  
İbrahim Özcan ◽  
İbrahim Hira ◽  
Altan Kaya ◽  
Mehmet Yaşar ◽  
Murat Doğan ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Predictive Value ◽  
Study Groups ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Diabetic Patients ◽  
Microvascular Damage ◽  
Distribution Width ◽  
Group 1

AbstractBackgroundWe aimed to evaluate the association between mean platelet volume, platelet distribution width (PDW), platelet count (PC) and plateletcrit (PCT), and the presence of sudden sensorineural hearing loss (SSNHL) and treatment response. In the literature, there is no study that investigates the platelet functions in diabetic patients with SSNHL.MethodsThe patients were retrospectively assigned into Group 1 (68 diabetic patients with SSNHL), Group 2 (63 nondiabetic patients with SSNHL) and Group 3 (64 healthy controls).ResultsPC was not significantly different between the groups (p > 0.05). MPV, PDW and PCT values were significantly higher in Group 1 as compared to Groups 2 and 3 (p < 0.05). Platelet parameters were not significantly different between the patients who were responsive and nonresponsive to the treatment. Therefore, the platelet parameters did not affect prognosis significantly in this study samples (p > 0.05).ConclusionsThis study showed that platelet parameters did not have a significant effect as a prognostic and predictive value in diabetic and nondiabetic patients with SSNHL. Further studies with more homogenous and larger study groups investigating the platelet parameters are needed to demonstrate microvascular damage and vascular alterations induced by diabetes mellitus.

scholarly journals Quality of life in individuals with tinnitus with and without hearing loss

Revista CEFAC ◽  
2017 ◽  
Vol 19 (6) ◽  
pp. 764-772 ◽  
Author(s):  
Gregorina Silva Ribeiro Rocha ◽  
Marlizete Maldonado Vargas ◽  
Margarete Zanardo Gomes
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
World Health ◽  
World Health Organization Quality ◽  
Auditory Thresholds ◽  
Group 4 ◽  
Group 1

ABSTRACT Purpose: to evaluate the perception of the level of quality of life in subjects with tinnitus, with and without hearing loss. Methods: a cross-sectional quantitative study. A total of 189 subjects (mean age 53.06 years) divided into four groups. Group 1: subjects with normal auditory thresholds without tinnitus complaint; Group 2: subjects with normal auditory thresholds and tinnitus complaint; Group 3: subjects with sensorineural hearing loss without tinnitus complaint; Group 4: subjects with sensorineural hearing loss and with tinnitus complaint. Levels of quality of life were investigated through the World Health Organization Quality Of Life (WHOQOL) website - brief and psycho-emotional and functional aspects of patients with tinnitus through the Tinnitus Handicap Inventory (THI). Statistical analyzes, comparisons among groups and descriptive analysis were performed, considering a significance level of 5%. Results: the overall mean scores of quality of life in group 4 (56.07) were smaller than those of group 1 (64.67) (p<0.05). The subjects with tinnitus complaint presented a moderate level of disturbance of the symptom. Conclusion: tinnitus interferes in the quality of life of individuals who had preserved or altered auditory thresholds. Therefore, means to reduce the discomfort caused by tinnitus symptom should be developed, in order to improve patients' quality of life.

Coenzyme Q 10 and Cardiovascular Risk Factors in Idiopathic Sudden Sensorineural Hearing Loss Patients

2007 ◽  
Vol 28 (7) ◽  
pp. 878-883 ◽  
Author(s):  
Gabriella Cadoni ◽  
Simona Scipione ◽  
Stefania Agostino ◽  
Giovanni Addolorato ◽  
Francesca Cianfrone ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hearing Loss ◽  
Cardiovascular Risk ◽  
Sensorineural Hearing Loss ◽  
Cardiovascular Risk Factors ◽  
Coenzyme Q ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing

Framingham risk score is associated with hearing outcomes in patients with idiopathic sudden sensorineural hearing loss

2020 ◽  
Vol 134 (5) ◽  
pp. 419-423
Author(s):  
Y-S Chang ◽  
S Park ◽  
M K Lee ◽  
Y C Rah ◽  
J Choi
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Risk Score ◽  
Pure Tone ◽  
Framingham Risk Score ◽  
Sudden Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Pure Tone Average ◽  
Framingham Risk ◽  
Group 1

AbstractObjectiveTo assess the Framingham risk score as a prognostic tool for idiopathic sudden sensorineural hearing loss patients.MethodsMedical records were reviewed for unilateral idiopathic sudden sensorineural hearing loss patients between January 2010 and October 2017. The 10-year risk of developing cardiovascular disease was calculated. Patients were subdivided into groups: group 1 – Framingham risk score of less than 10 per cent (n = 28); group 2 – score of 10 to less than 20 per cent (n = 6); and group 3 – score of 20 per cent or higher (n = 5).ResultsInitial pure tone average and Framingham risk score were not significantly associated (p = 0.32). Thirteen patients in group 1 recovered completely (46.4 per cent), but none in groups 2 and 3 showed complete recovery. Initial pure tone average and Framingham risk score were significantly associated in multivariable linear regression analysis (R2 = 0.36). The regression coefficient was 0.33 (p = 0.003) for initial pure tone average and −0.67 (p = 0.005) for Framingham risk score.ConclusionFramingham risk score may be useful in predicting outcomes for idiopathic sudden sensorineural hearing loss patients, as those with a higher score showed poorer hearing recovery.

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