Tumor-Infiltrating Lymphocytes in Patients With Advanced Laryngeal Cancer Undergoing Bioselection

2021 ◽  
pp. 019459982110137
Author(s):  
Molly E. Heft Neal ◽  
Joshua D. Smith ◽  
Andrew C. Birkeland ◽  
Catherine T. Haring ◽  
Steven B. Chinn ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Induction Chemotherapy ◽  
Neck Cancer ◽  
Tertiary Care ◽  
Tumor Infiltrating Lymphocytes ◽  
Care Hospital ◽  
Disease Specific Survival ◽  
Infiltrating Lymphocytes ◽  
Disease Specific

Objective Bioselection to assess tumor response after induction chemotherapy has been introduced as an alternative treatment strategy to total laryngectomy for patients with advanced larynx squamous cell carcinoma (LSCC). Tumor-infiltrating lymphocytes (TILs) have proven to serve as prognostic biomarkers in head and neck cancer but have not been evaluated as a way to select patients for treatment paradigms. The aim of this study is to evaluate the role of pretreatment TILs in patients with advanced LSCC undergoing the bioselection paradigm. Study Design Retrospective study. Setting Tertiary care hospital. Methods Patients with advanced LSCC treated with bioselection and available tissue were included (N = 76). Patients were stratified into CD8-low and CD8-high cohorts by using the median TIL count. Kaplan-Meier survival analysis and multivariate cox regression were performed with SPSS version 26 (IBM). Results After controlling for tobacco use, tumor site, and stage, a high CD8 TIL count was an independent predictor of improved 5-year disease-specific survival (hazard ratio, 0.17 [95% CI, 0.03-0.84]; P = .03). CD8 TIL counts did not predict response to induction chemotherapy; however, subgroup analysis of patients treated with chemoradiation therapy revealed that CD8 TIL count was significantly associated with degree of response ( P = .012). Conclusion These findings support prior data published by our group showing that TILs are predictive of disease-specific survival in patients with head and neck cancer. CD8 TIL counts were significantly associated with degree of clinical response after induction chemotherapy. These results suggest that pretreatment assessment of tumor-infiltrating CD8 cells could be useful in selecting patients.

You can't pay me to quit: the failure of financial incentives for smoking cessation in head and neck cancer patients

2016 ◽  
Vol 130 (3) ◽  
pp. 278-283 ◽  
Author(s):  
A Ghosh ◽  
G Philiponis ◽  
A Bewley ◽  
E R Ransom ◽  
N Mirza
Keyword(s):  
Smoking Cessation ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Financial Incentives ◽  
Past History ◽  
Tertiary Care ◽  
High Risk Population ◽  
Care Hospital ◽  
Incentive Group

AbstractObjective:A prospective randomised study was conducted at a tertiary care hospital to evaluate the effects of financial incentives for smoking cessation targeted at a high-risk population.Methods:Patients with a past history of head and neck cancer were voluntarily enrolled over a two-year period. They were randomised to a cash incentives or no incentive group. Subjects were offered enrolment in smoking cessation courses. Smoking by-product levels were assessed at 30 days, 3 months and 6 months. Subjects in the incentive group received $150 if smoking cessation was confirmed.Results:Over 2 years, 114 patients with an established diagnosis of head and neck cancer were offered enrolment. Twenty-four enrolled and 14 attended the smoking cessation classes. Only two successfully quit smoking at six months. Both these patients were in the financially incentivised group and received $150 at each test visit.Conclusion:Providing a financial incentive for smoking cessation to a population already carrying a diagnosis of head and neck cancer in order to promote a positive behaviour change was unsuccessful.

scholarly journals 901P Relationship between p16 and tumor-infiltrating lymphocytes in Peruvian patients with head and neck cancer

2021 ◽  
Vol 32 ◽  
pp. S802
Author(s):  
C.A. Castaneda ◽  
M. Castillo Garcia ◽  
L.A. Bernabe ◽  
J. Sanchez ◽  
K. Tello ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

scholarly journals Comparison of Open Gastrostomy and Percutaneous Endoscopic Gastrostomy in Head and Neck Cancer Patients, Tertiary Care Hospital Experience

2021 ◽  
Vol 5 (4) ◽  
pp. 166-170
Author(s):  
Talha Ahmed Qureshi ◽  
◽  
Shabir Akhtar ◽  
Sohail Awan ◽  
Amir Sharif ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Percutaneous Endoscopic Gastrostomy ◽  
Neck Cancer ◽  
Tertiary Care ◽  
Ethical Review ◽  
Care Hospital ◽  
Endoscopic Gastrostomy ◽  
Peristomal Infection

Abstract: Objective: The current study was conducted to review and compare PEG and Gastrostomy in terms of early complications in head and neck cancer patients. Materials and Methods: This was prospective comparative study recruited total 60 patients as per the inclusion criteria, 30 in each group. Patients were assigned to the groups based on the surgeon’s choice. Ethical clearance was taken from ethical review board. Informed consent was taken from patients before enrolling them into the study. Non-probability consecutive sampling technique was used to enroll study participants. Data was collected on pre-designed performa and analyzed using SPSS version 16. Setting: Section of Otolaryngology, Department of Surgery, Aga Khan University Hospital Karachi. Results: The two groups did not differ on basis of age, gender and tumor site. The outcomes variables including pain and bleeding from post-operative day1 to day 5 were significantly lower in patients who underwent PEG placement as compared to patients whom we performed OPEN gastrostomy. None the patient had peristomal infection in PEG group throughout the study. However, difference between the groups was statistically significant from post-operative day 3 to day 5. Conclusion: In our study, PEG was associated with lesser complications than open gastrostomy. Recently clinicians are using newer modalities like radiological and laparoscopic gastrostomy at various centres in Pakistan as the first option for placing feeding gastrostomy. Therefore, future studies are warranted to compare their efficacy and post-operative complications PEG. Keywords: Head and neck cancer, Open gastrostomy, Percutaneous endoscopic gastrostomy, Complications, Pain, Peristomal infection, Bleeding

scholarly journals Analysis of T Cell Receptor Variability in Fresh Tumor-infiltrating Lymphocytes from Human Head and Neck Cancer

1994 ◽  
Vol 85 (6) ◽  
pp. 626-632 ◽  
Author(s):  
Kazuaki Chikamatsu ◽  
Masao Eura ◽  
Koji Nakano ◽  
Yuichi Kanzaki ◽  
Hiroaki Matsuoka ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
T Cell ◽  
Head And Neck ◽  
T Cell Receptor ◽  
Neck Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Human Head ◽  
Cell Receptor ◽  
Infiltrating Lymphocytes

scholarly journals Tumor-infiltrating lymphocytes favor the response to chemoradiotherapy of head and neck cancer

2014 ◽  
Vol 3 (1) ◽  
pp. e27403 ◽  
Author(s):  
Panagiotis Balermpas ◽  
Franz Rödel ◽  
Christian Weiss ◽  
Claus Rödel ◽  
Emmanouil Fokas
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Tumor Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes
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