Peripheral Auditory Function in Young HIV-Positive Adults With Clinically Normal Hearing

2021 ◽  
pp. 019459982110471
Author(s):  
Christopher E. Niemczak ◽  
Travis White-Schwoch ◽  
Abigail Fellows ◽  
Albert Magohe ◽  
Jiang Gui ◽  
...  
Keyword(s):  
Young Adults ◽  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Normal Hearing ◽  
Hiv Positive ◽  
Auditory Function ◽  
Clinically Normal ◽  
Brainstem Response ◽  
Air Conduction ◽  
Hiv Negative

Objective Little is known about peripheral auditory function in young adults with HIV, who might be expected to show early evidence of hearing loss if HIV infection or treatment does affect peripheral function. The goal of this study was to compare peripheral auditory function in 2 age- and gender-matched groups of young adults with clinically normal hearing with and without HIV. Study Design Matched cohort study with repeated measures. Setting Infectious disease center in Dar es Salaam, Tanzania. Methods Participants included HIV-positive (n = 38) and HIV-negative (n = 38) adults aged 20 to 30 years who had clinically normal hearing, defined as type A tympanograms, air conduction thresholds ≤25 dB HL bilaterally from 0.5 to 8 kHz, and distortion product otoacoustic emissions (DPOAEs) >6 dB above the noise floor bilaterally from 1.5 to 8 kHz. Participants were tested multiple times over 6-month intervals (average, 2.7 sessions/participant) for a total of 208 observations. Primary outcome measures included tympanograms, air conduction audiograms, DPOAEs, and click-evoked auditory brainstem responses. Results HIV groups did not significantly differ in age, static immittance, or air conduction thresholds. HIV-positive status was independently associated with approximately 3.7-dB lower DPOAE amplitudes from 2 to 8 kHz (95% CI, 1.01-6.82) in both ears and 0.04-µV lower (95% CI, 0.003-0.076) auditory brainstem response wave I amplitudes in the right ear. Conclusion Young adults living with HIV have slightly but reliably smaller DPOAEs and auditory brainstem response wave I amplitudes than matched HIV-negative controls. The magnitude of these differences is small, but these results support measuring peripheral auditory function in HIV-positive individuals as they age.

scholarly journals Auditory brainstem response asymmetries in older adults: An exploratory study using click and speech stimuli

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251287
Author(s):  
Alejandro Ianiszewski ◽  
Adrian Fuente ◽  
Jean-Pierre Gagné
Keyword(s):  
Older Adults ◽  
Young Adults ◽  
Auditory Processing ◽  
Auditory Brainstem Response ◽  
Auditory Brainstem ◽  
Normal Hearing ◽  
Spectral Amplitude ◽  
Speech Stimuli ◽  
Brainstem Response ◽  
The Right

Background Some evidence suggests that young adults exhibit a selective laterality of auditory brainstem response (ABR) elicited with speech stimuli. Little is known about such an auditory laterality in older adults. Objective The aim of this study was to investigate possible asymmetric auditory brainstem processing between right and left ear presentation in older adults. Methods Sixty-two older adults presenting with normal hearing thresholds according to their age and who were native speakers of Quebec French participated in this study. ABR was recorded using click and a 40-ms /da/ syllable. ABR was elicited through monaural right and monaural left stimulation. Latency and amplitude for click-and speech-ABR components were compared between right and left ear presentations. In addition, for the /da/ syllable, a fast Fourier transform analysis of the sustained frequency-following response (FFR) of the vowel was performed along with stimulus-to-response and right-left ear correlation analyses. Results No significant differences between right and left ear presentation were found for amplitudes and latencies of the click-ABR components. Significantly shorter latencies for right ear presentation as compared to left ear presentation were observed for onset and offset transient components (V, A and O), sustained components (D and E), and voiced transition components (C) of the speech-ABR. In addition, the spectral amplitude of the fundamental frequency (F0) was significantly larger for the left ear presentation than the right ear presentation. Conclusions Results of this study show that older adults with normal hearing exhibit symmetric encoding for click stimuli at the brainstem level between the right and left ear presentation. However, they present with brainstem asymmetries for the encoding of selective stimulus components of the speech-ABR between the right and left ear presentation. The right ear presentation of a /da/ syllable elicited reduced neural timing for both transient and sustained components compared to the left ear. Conversely, a stronger left ear F0 encoding was observed. These findings suggest that at a preattentive, sensory stage of auditory processing, older adults lateralize speech stimuli similarly to young adults.

Normal Brief-Tone Bone-Conduction Behavioral Thresholds Using the B-71 Transducer: Three Occlusion Conditions

2003 ◽  
Vol 14 (10) ◽  
pp. 556-562 ◽  
Author(s):  
Susan A. Small ◽  
David R. Stapells
Keyword(s):  
Auditory Brainstem Response ◽  
Pure Tone ◽  
Bone Conduction ◽  
Auditory Brainstem ◽  
Behavioral Thresholds ◽  
Brainstem Response ◽  
Occlusion Effect ◽  
Response Testing ◽  
Brief Tones ◽  
Air Conduction

Behavioral thresholds were measured from 31 adults with normal hearing for 500, 1000, 2000, and 4000 Hz brief tones presented using a B-71 bone oscillator. Three occlusion conditions were assessed: ears unoccluded, one ear occluded, and both ears occluded. Mean threshold force levels were 67, 54, 49, and 41 dB re:1μN peak-to-peak equivalent in the unoccluded condition for 500, 1000, 2000, and 4000 Hz, respectively (corrected for air-conduction pure-tone thresholds). A significant occlusion effect was observed for 500 and 1000 Hz stimuli. These thresholds may be used as the 0 dB nHL (normalhearing level) for brief-tone bone-conduction stimuli for auditory brainstem response testing.

Use of Contralateral Masking in the Measurement of the Auditory Brainstem Response

1982 ◽  
Vol 25 (4) ◽  
pp. 528-535 ◽  
Author(s):  
Larry E. Humes ◽  
Marleen G. Ochs
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Auditory Brainstem Response ◽  
Mean Amplitude ◽  
Auditory Brainstem ◽  
Normal Hearing ◽  
Brainstem Response ◽  
The Mean ◽  
Intensity Functions ◽  
Contralateral Masking

In the first portion this study, the effects of two levels of contralateral masking on the auditory brainstem response (ABR) were investigated in 10 normal-hearing subjects. No significant changes were observed in the mean latency-intensity functions or the mean amplitude-intensity functions of this group of subjects when noise of various levels was added to the nontest ear. In the second portion of this study, ABRs were also recorded from the poorer ear of four subjects with a profound unilateral sensorineural hearing loss. Results from the latter group revealed a crossed-over wave V in all cases when the stimulus was delivered to the poorer ear and the nontest (better) ear was not masked. Contralateral masking obliterated this "crossed ABB" in all four unilaterally impaired subjects. These results provide support for the use of contralateral masking when recording from the poorer ear of subjects having asymmetrical hearing loss.

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