Systemic Reactions to Immunotherapy: The American Academy of Otolaryngic Allergy Morbidity and Mortality Survey

1994 ◽  
Vol 110 (6) ◽  
pp. 487-493 ◽  
Author(s):  
Paul R. Cook ◽  
James L. Bryant ◽  
William E. Davis ◽  
Theodore T. Benke ◽  
Arnold S. Rapoport
Keyword(s):  
Hypersensitivity Reaction ◽  
American Academy ◽  
Nasal Obstruction ◽  
Reaction Rate ◽  
Immunoglobulin E ◽  
Systemic Reaction ◽  
Type I ◽  
Systemic Reactions ◽  
Type I Hypersensitivity ◽  
Mortality Survey

Anaphylaxis may be defined as a systemic, Immunoglobulin E-mediated (Gell-Coombs type I) hypersensitivity reaction triggered by exposure to an antigen in a previously sensitized patient. Anaphylaxis may occur in a varlety of circumstances: however, when it occurs as the result of Immunotherapy, it is of great concern to the practicing allergist. When describing or reporting anaphylaxis relating to Immunotherapy, most allergists speak in terms of the types of reactions, local vs. systemic. Germane to this discussion is the use of the term systemic reaction, which can mean anything from mild allergy symptoms resulting from an allergy injection to bradycardia and hypotension (shock). In this article we report serious or significant systemic reactions, which are characterized by any of the following symptoms: urticaria, sneezing or nasal obstruction, throat tightness or congestion, wheezing, and shock (bradycardta or hypotension). There were no fatalities reported from the survey group. The overall reaction rate was 0.3%.

Effects of magnolialide isolated from the leaves of Laurus nobilis L. (Lauraceae) on immunoglobulin E-mediated type I hypersensitivity in vitro

2013 ◽  
Vol 149 (2) ◽  
pp. 550-556 ◽  
Author(s):  
Taehun Lee ◽  
Sooryun Lee ◽  
Kyeong Ho Kim ◽  
Ki-Bong Oh ◽  
Jongheon Shin ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Type I ◽  
Laurus Nobilis ◽  
Type I Hypersensitivity

scholarly journals Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation

2021 ◽  
Vol 55 (1) ◽  
pp. 54
Author(s):  
Nur Moya Isyroqiyyah ◽  
Gatot Soegiarto ◽  
Yuani Setiawati
Keyword(s):  
Hypersensitivity Reaction ◽  
Drug Hypersensitivity ◽  
Demographic Data ◽  
Stevens Johnson Syndrome ◽  
Type I ◽  
Type Iv ◽  
Drug Eruptions ◽  
Johnson Syndrome ◽  
Drug Hypersensitivity Reaction ◽  
Type I Hypersensitivity

Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient’s demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.

Biomarkers for non-human primate Type-I hypersensitivity: Antigen-specific immunoglobulin E assays

2013 ◽  
Vol 392 (1-2) ◽  
pp. 29-37 ◽  
Author(s):  
Darcey Clark ◽  
Faith Shiota ◽  
Carla Forte ◽  
Padma Narayanan ◽  
Daniel T. Mytych ◽  
...  
Keyword(s):  
Immunoglobulin E ◽  
Type I ◽  
Specific Immunoglobulin E ◽  
Specific Immunoglobulin ◽  
Type I Hypersensitivity ◽  
Human Primate

scholarly journals INTRAOPERATIVE EMBOLISM OR TYPE I HYPERSENSITIVITY REACTION TO GELOFUSINE®

2019 ◽  
Vol 05 (06) ◽  
pp. 582-584
Author(s):  
Aishwarya Ramkrishnan ◽  
Meenakshi V V ◽  
Karthikeyan .
Keyword(s):  
Hypersensitivity Reaction ◽  
Type I ◽  
Type I Hypersensitivity

scholarly journals Increased IgE Deposition in Appendicular Tissue Specimens Is Compatible with a Type I Hypersensitivity Reaction in Acute Appendicitis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Nuno Carvalho ◽  
André Barros ◽  
Hélder Coelho ◽  
Ana Cóias ◽  
Pedro Botelho ◽  
...  
Keyword(s):  
Acute Appendicitis ◽  
Hypersensitivity Reaction ◽  
Allergic Reaction ◽  
Standard Procedure ◽  
Control Group ◽  
Common Disease ◽  
Type I ◽  
Tissue Destruction ◽  
Gangrenous Appendicitis ◽  
Type I Hypersensitivity

Background. IgE mediates type I hypersensitivity reaction and can be found in the mucosa of organs affected by allergy. Acute appendicitis (AA) is a common disease, but its etiology remains poorly understood. Here, we investigated IgE deposition in histological sections of AA samples to test the hypothesis that an allergic reaction may substantially contribute to the pathophysiology of AA. Materials and Methods. In a retrospective study, we assessed the presence of IgE in appendicular specimens of histologically confirmed appendicitis and in the control group, comprised of negative appendicitis and incidental appendectomies, using a monoclonal antibody against human IgE. Samples from 134 appendectomies were included: 38 phlegmonous and 27 gangrenous appendicitis from the study group and 52 incidental appendectomies and 17 negative appendicitis from the control group. The slides were visualized by light microscopy, and a standard procedure was used to manually count the positive IgE staining cells. Results. IgE staining was present in the cells of all but 5 appendicular specimens. We found a significantly increased number of IgE-positive cells in phlegmonous AA ( median = 28 ) when compared to incidental appendectomy ( median = 17 ) ( p = 0.005 ; p < 0.0001 when adjusted for age and gender). No difference was found for gangrenous appendicitis. Discussion. The presence of IgE supports the contribution of an allergic reaction for the pathophysiology of phlegmonous appendicitis. The reduced number of IgE staining cells in gangrenous appendicitis can be due to tissue destruction, or, as been claimed by others, gangrenous appendicitis is a distinct entity, with different etiology. Conclusion. In this study, phlegmonous appendicitis had the highest number of IgE-positive appendicular cells. These findings suggest that an allergic reaction can contribute to the pathophysiology of AA, opening a novel possibility for preventive measures in a disease that typically requires surgery.

scholarly journals Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation

2019 ◽  
Vol 55 (1) ◽  
pp. 54
Author(s):  
Nur Moya Isyroqiyyah ◽  
Gatot Soegiarto ◽  
Yuani Setiawati
Keyword(s):  
Hypersensitivity Reaction ◽  
Drug Hypersensitivity ◽  
Demographic Data ◽  
Stevens Johnson Syndrome ◽  
Type I ◽  
Type Iv ◽  
Drug Eruptions ◽  
Johnson Syndrome ◽  
Drug Hypersensitivity Reaction ◽  
Type I Hypersensitivity

Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient’s demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.

Oral nickel exposure may induce Type I hypersensitivity reaction in nickel-sensitized subjects

2015 ◽  
Vol 26 (1) ◽  
pp. 92-96 ◽  
Author(s):  
Suna Büyüköztürk ◽  
Aslı Gelincik ◽  
Derya Ünal ◽  
Mustafa Demirtürk ◽  
Dolay Damla Çelik ◽  
...  
Keyword(s):  
Hypersensitivity Reaction ◽  
Type I ◽  
Nickel Exposure ◽  
Type I Hypersensitivity

scholarly journals Fungal allergens.

1995 ◽  
Vol 8 (2) ◽  
pp. 161-179 ◽  
Author(s):  
W E Horner ◽  
A Helbling ◽  
J E Salvaggio ◽  
S B Lehrer
Keyword(s):  
Immunoglobulin E ◽  
Fungal Spores ◽  
Pollen Grains ◽  
Type I ◽  
Fungal Allergens ◽  
Fungal Allergy ◽  
Airborne Fungal Spores ◽  
Specific Antigens ◽  
Type I Hypersensitivity ◽  
Allergy Prevalence

Airborne fungal spores occur widely and often in far greater concentrations than pollen grains. Immunoglobulin E-specific antigens (allergens) on airborne fungal spores induce type I hypersensitivity (allergic) respiratory reactions in sensitized atopic subjects, causing rhinitis and/or asthma. The prevalence of respiratory allergy to fungi is imprecisely known but is estimated at 20 to 30% of atopic (allergy-predisposed) individuals or up to 6% of the general population. Diagnosis and immunotherapy of allergy to fungi require well-characterized or standardized extracts that contain the relevant allergen(s) of the appropriate fungus. Production of standardized extracts is difficult since fungal extracts are complex mixtures and a variety of fungi are allergenic. Thus, the currently available extracts are largely nonstandardized, even uncharacterized, crude extracts. Recent significant progress in isolating and characterizing relevant fungal allergens is summarized in the present review. Particularly, some allergens from the genera Alternaria, Aspergillus, and Cladosporium are now thoroughly characterized, and allergens from several other genera, including some basidiomycetes, have also been purified. The availability of these extracts will facilitate definitive studies of fungal allergy prevalence and immunotherapy efficacy as well as enhance both the diagnosis and therapy of fungal allergy.

Anaphylaxis

2007 ◽  
pp. 109-112
Keyword(s):  
Hypersensitivity Reaction ◽  
Specific Antigen ◽  
Platelet Activating Factor ◽  
Prior Exposure ◽  
Type I ◽  
Subsequent Exposure ◽  
Mucosal Oedema ◽  
Ige Mediated ◽  
The Individual ◽  
Type I Hypersensitivity

Anaphylaxis 110 Anaphylactic reactions (type I hypersensitivity reaction) are the consequence of the cascade caused by an IgE-mediated response to a specific antigen. Prior exposure to the antigen sensitizes the individual, so that subsequent exposure results in prostaglandin, leukotriene, and platelet activating factor generation and thereby histamine release. This results in vasodilatation, bronchial mucosal oedema, and bronchoconstriction....

Sign in / Sign up

Export Citation Format

Share Document