Digit ratio and hair color relationships with coronary atherosclerotic markers

2019 ◽  
Vol 27 (5) ◽  
pp. 362-368
Author(s):  
Hussein Nafakhi ◽  
Abdulameer A Al-Mosawi ◽  
Mundher M Mudhafar ◽  
Hasan A Al-Nafakh ◽  
Rana Alsaady
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Coronary Plaque ◽  
White Hair ◽  
Digit Ratio ◽  
Hair Color ◽  
Pericardial Fat ◽  
Fourth Digit ◽  
Fat Volume ◽  
Pure White

Objective We aimed to investigate the association between body phenotype markers and coronary atherosclerosis markers. Methods Eighty-nine patients (mean age 57 ± 9 years, 50.5% male) who were assessed for coronary artery disease by 64-slice multidetector computed tomography angiography were enrolled in the study. Results A significant positive association was observed between coronary artery calcification and the second to fourth digit ratio ( r = 0.2, p = 0.00); more notably in males compared to females ( p = 0.03 vs. p = 0.08). There was a significant association between coronary artery calcification and pure white hair ( p = 0.00). There was no significant association between pericardial fat volume and second to fourth digit ratio ( p = 0.8). Pericardial fat volume was significantly associated with pure white hair ( p = 0.02). A significant association was observed between coronary plaque and a higher second to fourth digit ratio ( p = 0.01) and this was more notable in males ( p = 0.04). A significant association was observed between pure white hair and coronary plaque ( p = 0.00). After adjustment for conventional cardiac risk factors, the association of coronary artery calcification and coronary plaque with the second to fourth digit ratio did not persist, whereas the association of pericardial fat volume and coronary artery calcification with pure white hair remained significant ( p = 0.01 and p = 0.00, respectively). Conclusion These results suggest a possible predictive value of hair color, rather than digit ratio, in assessing increased risk of coronary atherosclerosis and cardiac fat deposition.

Sex-Related Differences in the Association of BMI and Pericardial Fat Volume With Coronary Atherosclerotic Markers in Young

Angiology ◽  
2020 ◽  
pp. 000331972097423
Author(s):  
Hussein Nafakhi ◽  
Abdulameer A. Al-Mosawi ◽  
Karrar al-Buthabhak
Keyword(s):  
Coronary Artery ◽  
Young Patients ◽  
Young Male ◽  
Calcium Score ◽  
Coronary Plaque ◽  
Pericardial Fat ◽  
Calcified Plaque ◽  
Luminal Stenosis ◽  
Independent Association ◽  
Fat Volume

We assessed sex-related differences in the association of pericardial fat volume (PFV) and obesity measured by body mass index (BMI) with coronary atherosclerotic markers (coronary artery calcium score [CAC], coronary luminal stenosis severity, and coronary plaque) in young patients. Patients (n = 174; age <50 years) with suspected coronary artery disease who underwent 64-slice multidetector computed tomography angiography were enrolled. Females tended to have a younger age and increased BMI, normal coronary arteries (free from luminal stenosis), and increased percentage of absent coronary plaque compared with males. There was a significant independent association between PFV with coronary luminal stenosis and between PFV and BMI with coronary noncalcified plaque presence after adjustment for conventional cardiac risk factors. On the other hand, males showed a more increment in PFV, CAC, percentage of calcified plaque, and percentage of significant coronary luminal stenosis compared with females. There was a significant independent association of PFV with CAC, significant coronary stenosis, and calcified plaque presence, while no association was observed between BMI with coronary markers in young males. In conclusion, PFV, but not BMI, showed a significant independent association with advanced coronary atherosclerosis in young male patients.

scholarly journals CHANGE IN EPICARDIAL FAT VOLUME: IS IT RELATED TO THE DEVELOPMENT OF NEW CORONARY ARTERY CALCIFICATION?

2011 ◽  
Vol 57 (14) ◽  
pp. E825
Author(s):  
Yuka Otaki ◽  
Damini Dey ◽  
Victor Cheng ◽  
Rine Nakanishi ◽  
Ronak Rajani ◽  
...  
Keyword(s):  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Epicardial Fat ◽  
Epicardial Fat Volume ◽  
Fat Volume

Abstract 19690: Association of Pericardial Fat Density With Progression of Coronary Artery Calcification Differs by Diabetes Status in the CACTI Study

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Amy C Alman ◽  
Steven R Smith ◽  
Preethi R Sudini ◽  
Robert H Eckel ◽  
John E Hokanson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Coronary Artery Calcification ◽  
Subclinical Atherosclerosis ◽  
Pericardial Fat ◽  
Progression Model ◽  
Interaction Terms ◽  
Diabetes Status

Density of adipose tissue can be measured by CT attenuation in Hounsfield Units (HU). Increased visceral fat density has been associated with coronary artery calcification (CAC). However, the relationship between pericardial fat density and CAC is unknown. We examined the association of pericardial fat density (PAT HU) with the presence (CAC > 0) and progression of CAC in the Coronary Artery Calcification in Type 1 Diabetes study (CACTI). CACTI is a prospective cohort study of adults with and without type 1 diabetes (T1D) with a mean age of 38 years (±9) at baseline. Participants were free of CVD at the time of enrollment in the study. PAT volume was measured from baseline EBCT scans within a range of HU from -190 to -30. CAC was measured at baseline and at the follow-up exam with a mean follow-up of 6 years (±0.5). Logistic regression was used to examine the association between PAT HU and CAC. Prevalence of CAC was defined as any CAC (>0) at baseline. Progression of CAC was defined as a change in volume of ≥2.5 square-root transformed units between the baseline and followup exams. PAT volume and triglycerides were log transformed. Interaction terms for diabetes and PAT HU were tested in the models. PAT data were available on 1319 subjects for the prevalence model, and 952 for the progression model. PAT HU was significantly higher (less-negative) in those with T1D compared to those without (-75.7 ±3.7 vs -77.8 ±4.2; p<0.001). Results from the regression models are shown in table 1. Increasing PAT HU was significantly associated with the prevalence of CAC in both those with T1D and without. However, increasing PAT HU was significantly associated with progression of CAC only in those with T1D. These results suggest that higher PAT fat density may be an important factor in subclinical atherosclerosis, particularly for those with T1D.

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