scholarly journals Myocardial cytochrome oxidase activity increases with age and hypoxemia in patients with congenital heart disease

Perfusion ◽  
2016 ◽  
Vol 32 (4) ◽  
pp. 306-312 ◽  
Author(s):  
Michael Onwugbufor ◽  
Richard J. Levy ◽  
David Zurakowski ◽  
Richard A. Jonas ◽  
Pranava Sinha
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Steady State ◽  
Oxygen Saturation ◽  
Protein Content ◽  
Congenital Heart ◽  
Right Atrial ◽  
Arterial Oxygen ◽  
State Activity ◽  
Steady State Activity

Background: Myocardial tolerance to ischemia is influenced by age and preoperative cyanosis through unknown mechanisms and significantly affects postoperative outcomes. Cytochrome c oxidase (CcOx), the terminal enzyme of the mitochondrial electron transport chain, may play a role in the susceptibility to ischemic-reperfusion (IR) injury. Our study aimed at investigating changes in human myocardial CcOx activity based on age and preoperative oxygen saturation to understand its role in transition from neonatal to mature myocardium and hypoxic conditions. Methods: The right atrial appendage from patients undergoing first time surgical repair/palliation of congenital heart defects was analyzed for steady state CcOx activity by oxidation of ferrocytochrome c via spectrophotometry and steady state CcOx subunit I protein content by protein immunoblotting. Student’s t-test compared CcOx activity and protein levels between patients with preoperative hypoxia and normoxia. Multiple linear regression analysis was used to assess the effects of age and preoperative arterial oxygen saturations (SaO2) on CcOx protein activity and protein content. Results: Thirty-two patients with a median (interquartile range) age of 83 days (8-174) and preoperative oxygen saturation 98% (85-100%) were enrolled. Independent of age, preoperative SaO2 ⩽90% was associated with significantly greater CcOx steady state activity (p=0.004). Additionally, older age itself was associated with increased CcOx steady state activity (p=0.022); the combination of preoperative SaO2 and age account for 33% of the variation in CcOx steady state activity (R2=0.332). There was no increase in the CcOx subunit I protein content with either age or preoperative hypoxia. Conclusions: In patients with congenital heart disease, an increase in CcOx steady state activity is seen with increasing age. Hypoxia leads to upregulation of CcOx steady state activity without an increase in the amount of enzyme protein itself. Higher CcOx activity in older and cyanotic patients may indicate CcOx-dependent reactive oxygen species as the mechanism for IR injury.

Continuous observations of the arterial oxygen saturation at rest and during exercise in congenital heart disease

1948 ◽  
Vol 36 (5) ◽  
pp. 668-682 ◽  
Author(s):  
George E. Montgomery ◽  
Earl H. Wood ◽  
Howard B. Burchell ◽  
Thomas J. Dry ◽  
Robert L. Parker ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Oxygen Saturation ◽  
Congenital Heart ◽  
Arterial Oxygen Saturation ◽  
Arterial Oxygen

scholarly journals Low peripheral oxygen saturation as a risk factor for brain abscess in children with cyanotic congenital heart disease

2018 ◽  
Vol 58 (5) ◽  
pp. 252-6
Author(s):  
Nadia Qoriah Firdausy ◽  
Indah Kartika Murni ◽  
Agung Triono ◽  
Noormanto Noormanto ◽  
Sasmito Nugroho
Keyword(s):  
Congenital Heart Disease ◽  
Risk Factor ◽  
Heart Disease ◽  
Oxygen Saturation ◽  
Brain Abscess ◽  
Congenital Heart ◽  
Significant Risk ◽  
Cyanotic Congenital Heart Disease ◽  
Arterial Oxygen ◽  
Peripheral Oxygen Saturation

Background Brain abscess is a severe infection of brain parenchyma, which occurs in 25-46% of cases of uncorrected cyanotic congenital heart disease. Low arterial oxygen saturation is the main risk factor for brain abscess in children with cyanotic congenital heart disease, however, the arterial oxygen saturation test is invasive and not routinely done in our setting. Objective To evaluate low peripheral oxygen saturation as a risk factor for brain abscess in children with cyanotic congenital heart disease. Methods We conducted a matched, case-control study at Sardjito Hospital, Yogyakarta for children aged less than 18 years with cyanotic congenital heart disease, from 2010-2016. Case subjects were children with brain abscess complications. The control group had only cyanotic congenital heart disease, and were matched for age and sex to the case group. During hospitalization due to the brain abscess complication in the case group, data regarding peripheral oxygen saturation, polycythemia, pneumonia, sepsis, dental caries and restricted pulmonary blood flow were collected and compared between both groups. Results During the study period, 18 children with cyanotic congenital heart disease had brain abscesses. This group was compared to the control group of 36 children. Bivariate analysis revealed that the lowest level of peripheral oxygen saturation (OR 0.92; 95%CI 0.85 to 0.98; P=0.02) and dental caries (OR 3.3; 95%CI 1.01 to 11.18; P=0.04) were significant risk factors for brain abscess. However, in the multivariate analysis, the only statistically significant risk factor associated with brain abscess was the lowest level of peripheral oxygen saturation (OR 0.92; 95%CI 0.86 to 0.99; P=0.04). Conclusion Low peripheral oxygen saturation is a significant risk factor for brain abscess development in children with cyanotic congenital heart disease.  A decrease of 1% peripheral oxygen saturation may increase the risk of brain abscess by 8%.

scholarly journals Comparative study of pulse oximetry, physical examination and echocardiography results in the diagnosis of congenital heart defects in neonates in the first 24 hours of life

2021 ◽  
Author(s):  
Fatemeh Amiri Simkouii ◽  
Maryam Jamshidi ◽  
Mostafa Behjati Ardakani ◽  
Farzaneh Toosi ◽  
Mohammad Reza Alipour ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Physical Examination ◽  
Oxygen Saturation ◽  
Pulse Oximetry ◽  
Congenital Heart ◽  
Statistical Tests ◽  
Arterial Oxygen Saturation ◽  
Screening Method ◽  
Arterial Oxygen

Introduction: Congenital heart disease is the most common congenital anomaly. About 50% of Neonates with congenital heart disease are asymptomatic in the first few days of life and are not diagnosed on initial examination. Pulse oximetry is a non-invasive method that can show the percentage of oxygen saturation in the blood and congenital heart disease. Methods: This was a descriptive cross-sectional study and the sampling method was census. Echocardiography was performed for all neonates with spo2 less than 95% and also neonates who were diagnosed with a problem by a cardiologist. After collecting the samples, the results obtained from pulse oximetry, physical examination and echocardiography were analyzed using SPSS software version 16 and statistical tests of Kolmogorov-Smirnov normality and Spearman correlation. Was investigated. Results: In pulse oximetry evaluation, 1.9% of neonates had spo2 (arterial oxygen saturation) less than 95%. 1.7% of neonates had heart problems in physical examination and 2.12% of neonates had heart problems in echocardiography. The highest correlation between pulse oximetry and echocardiography was 0.917. Conclusion: Considering the diagnostic importance of congenital heart diseases and their impact on a person's life, it is recommended that pulse oximetry be added to physical examinations at birth as a screening method for heart disease.

Effect of premedication on arterial oxygen saturation in children with congenital heart disease

1990 ◽  
Vol 4 (4) ◽  
pp. 425-429 ◽  
Author(s):  
T.L. DeBock ◽  
P.J. Davis ◽  
J. Tome ◽  
R. Petrilli ◽  
R.D. Siewers ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Oxygen Saturation ◽  
Congenital Heart ◽  
Arterial Oxygen Saturation ◽  
Arterial Oxygen
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