Veno-active drugs for chronic venous disease: A randomized, double-blind, placebo-controlled parallel-design trial

2013 ◽  
Vol 29 (7) ◽  
pp. 454-460 ◽  
Author(s):  
Sergio Q Belczak ◽  
Igor R Sincos ◽  
Walter Campos ◽  
Julio Beserra ◽  
Gilberto Nering ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Range Of Motion ◽  
Symptom Relief ◽  
Chronic Venous Disease ◽  
Pharmacological Intervention ◽  
Venous Disease ◽  
Joint Range Of Motion ◽  
Patient Reported ◽  
Joint Range

Introduction: Our current understanding of the pathophysiology of chronic venous disease (CVD) suggests that veno-active drugs (VAD) can provide effective symptom relief. Few studies have conducted head-to-head comparisons of VAD and placebo while also assessing objective measures (such as water plethysmography findings and tibiotarsal joint range of motion) and patient-reported quality of life outcomes. Objectives: To compare the effects of different VAD on limb volume reduction, tibiotarsal range of motion, and quality of life. Methods: 136 patients with CVD (CEAP grades 2–5) were randomly allocated into four groups to receive micronized diosmin + hesperidin, aminaphthone, coumarin + troxerutin, or placebo (starch). Patients were administered a questionnaire consisting of a quality of life (QoL) measure designed specifically for persons with CVD, and underwent tibiotarsal joint angle measurement and water plethysmography of the lower extremity before and 30 days after pharmacological intervention. Assessors were blind to the treatment groups. Results: Nine patients dropped out of the trial. Data collected from the 127 remaining patients was considered for statistical analysis. There were no differences in tibiotarsal joint range of motion. Volume reductions ≥100 mL were more frequent in the diosmin + hesperidin group than in any other group. QoL scores were best in the aminaphthone group, and between-group differences were found on individual analysis of questionnaire items. Conclusions: Use of VAD was associated with significant improvements in QoL as compared with placebo. VAD may be effective for providing symptom relief in patients with CVD.

scholarly journals Impact of local cryogymnastic on functional efficiency, quality of life and pain perception among patients with gonarthrosis

2012 ◽  
Vol 26 (3) ◽  
pp. 27-33
Author(s):  
Teresa Pop ◽  
Bartłomiej Skrzypek ◽  
Katarzyna Pop ◽  
Wojciech Rusek
Keyword(s):  
Quality Of Life ◽  
Knee Osteoarthritis ◽  
Range Of Motion ◽  
Safe Procedure ◽  
Common Cause ◽  
Joint Range Of Motion ◽  
Functional Efficiency ◽  
Local Cryotherapy ◽  
Joint Range

Abstract Introduction: Gonarthrosis is the most common disease of peripheral joints. Among population of developing countries, it concerns about 70% of people over 65 year of age. Because its chronic, progressive and irreversible nature it is one of the most common cause of work incapacity. It is also a common cause of disability in people in six decade of life. Objective: The aim of this study was to evaluate the effect of cryogymnastic on quality of life and functional efficiency of patients with knee osteoarthritis. Material and methods: The study consisted of group of 50 people diagnosed with osteoarthritis of the knee (gonarthrosis). Patients were tested twice. First examination was conducted before the start of therapy, a second examination was conducted after 10 treatments cryotherapy. To evaluate the results of cryogymnastic we used goniometric measurement, WOMAC questionnaire and functional test Up & Go. Results: We found that applied local cryotherapy and exercise in studied group had been effective in increasing joint range of motion, improving quality of life and patients’ functional efficiency. Conclusions: 1. Our treatment for patients with knee arthritis after local cryotherapy and exercises improved significantly joint range of motion, quality of life and functional efficiency. 2. Local cryotherapy is a safe procedure and well tolerated by patients with knee osteoarthritis.

scholarly journals Effect of joint range of motion on health-related quality of life in children with hemophilia

2019 ◽  
Vol 46 (4) ◽  
pp. 237
Author(s):  
NermeenAhmed Foaud ◽  
ManalAnwar El Hawary ◽  
HanaaHassan EL Dash ◽  
MonaHussien Mohamed
Keyword(s):  
Quality Of Life ◽  
Range Of Motion ◽  
Health Related Quality ◽  
Joint Range Of Motion ◽  
Related Quality ◽  
Health Related ◽  
Joint Range

scholarly journals Changes and Associations between Cervical Range of Motion, Pain, Temporomandibular Joint Range of Motion and Quality of Life in Individuals with Migraine Applying Physiotherapy: A Pilot Study

Medicina ◽  
2021 ◽  
Vol 57 (6) ◽  
pp. 630
Author(s):  
Egle Lendraitiene ◽  
Laura Smilgiene ◽  
Daiva Petruseviciene ◽  
Raimondas Savickas
Keyword(s):  
Quality Of Life ◽  
Aerobic Exercise ◽  
Range Of Motion ◽  
Temporomandibular Joint ◽  
Activity Limitation ◽  
Upper Trapezius ◽  
Joint Range Of Motion ◽  
Pressure Pain Thresholds ◽  
Joint Range

Background and Objectives: The aim of this study was to assess the effects of physiotherapy with aerobic exercise together with temporomandibular joint range of motion exercises (supervised) and physiotherapy with aerobic exercise only (unsupervised), also to review the correlations between neck movements, pain, temporomandibular joint range of motion movements and quality of life in individuals with migraine. Methods: The flexion, extension and lateral flexion of the cervical spine were measured in degrees with a mechanical goniometer and pressure pain thresholds with algometer. Quality of life was assessed with the SF-36 questionnaire and temporomandibular joint range of motion with a centimeter. Results: The study showed statistically significant cervical flexion results in both groups (p < 0.05), masticatory muscle results and temporomandibular joint range of motion between the groups (p < 0.05). A correlation between left upper trapezius muscle pain and cervical lateral flexion was observed in the intervention group. Physical activity correlated with cervical extension, activity limitation due to physical ailments and general health. A correlation between temporomandibular joint and right-side masticatory muscles pain was found. A correlation between upper trapezius muscle pain and left- as well as right-side temporalis muscles were found in the control group. Strong correlations were found between pain and activity limitation due to physical ailments and emotional state. The temporomandibular joint range of motion strongly correlated with activity limitation due to physical ailments. Conclusions: Physiotherapy based on aerobic exercises together with temporomandibular joint exercises was more effective than physiotherapy based on aerobic exercise for decreasing pain, increasing pressure pain thresholds and cervical range of motion.

Compression versus inner sole for venous patients with foot static disorders: a prospective trial comparing symptoms and quality of life

2013 ◽  
Vol 30 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Jean-François Uhl ◽  
Maxime Chahim ◽  
François-André Allaert
Keyword(s):  
Quality Of Life ◽  
Prospective Trial ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Compression Stockings ◽  
Static Disorder ◽  
Postural Changes ◽  
Patient Reported ◽  
Medical Compression Stockings

Objective To prospectively compare the improvement in quality of life and symptoms achieved when using two treatments—medical compression stockings and inner sole—in subjects with symptomatic chronic venous disease in the presence of foot static disorders. Materials and methods This prospective study included 24 patients with a symptomatic chronic venous disease associated with foot static disorders. The basic CEAP was used to classify the patients. The venous symptoms were recorded using a 10-point visual analog scale and scored using a customized questionnaire. Patient-reported quality of life data were acquired using a CIVIC questionnaire. A standardized measurement of the Djian-Annonier angle was used to quantify the foot static disorders. We compared the use of the following two treatments: medical compression stockings (18 mm of Hg) and inner sole. For this comparison, we used a crossover technique over 4 successive weeks. Results One male and 23 female patients were included in this study. We found significant improvement in quality of life scores when only medical compression stockings were used ( p < 0.005), only inner sole were used ( p < 0.01) and also when both treatments were used together ( p < 0.001), compared with no treatment. This was mainly observed for the somatic component of CIVIC. The symptoms of pain, heaviness, swollen feeling, and cramps were significantly improved by the two treatments, whether given separately ( p < 0.001) or together ( p < 0.0001). No additive effect of the treatments was observed. Conclusion This study suggests that a number of leg symptoms occurring in varicose veins patients are not likely to have a venous origin. They are frequently related to a foot static disorder, which is responsible for postural changes. This study also strongly demonstrates the need for correction of the foot static disorder if such a disorder is present in any patient with chronic venous disease. The use of the inner sole will improve the symptoms and also the quality of life with an efficiency that is almost equal to that provided by the medical compression stockings and the combined use of both treatments is recommended.

Linguistic validation of the 20 item-chronic venous disease quality-of-life questionnaire (CIVIQ-20)

2013 ◽  
Vol 29 (7) ◽  
pp. 484-487 ◽  
Author(s):  
R Launois ◽  
A Mansilha ◽  
F Lozano
Keyword(s):  
Quality Of Life ◽  
Mother Tongue ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Life Questionnaire ◽  
Linguistic Validation ◽  
Semantic Equivalence ◽  
Quality Of Life Questionnaire ◽  
Venous Ulcers

Our objective was to review the linguistic validation of the 20 item-ChronIc Venous dIsease quality-of-life Questionnaire (CIVIQ-20) in the countries that have used it since its publication in 1996. Seventeen linguistic versions of CIVIQ-20 were validated using forward/backward methodology in patients presenting with chronic venous disease, stages C0s to C4 of the CEAP (clinical, aetiological, anatomical and pathological) classification (patients with venous ulcers were excluded). Most obstacles in the cross-cultural validation of CIVIQ-20 related to content and semantic equivalence. Confirmation of cultural relevance by experts with the native language as their mother tongue and the use of forward/backward translation methodology partly resolved these difficulties. CIVIQ-20 is valid for the assessment of treatment effects in multinational studies.

A comparison of the effects of joint immobilisation, twice-daily passive motion, and voluntary motion on articular cartilage healing in sheep

2002 ◽  
Vol 15 (01) ◽  
pp. 23-29 ◽  
Author(s):  
K. Frame ◽  
H. M. Burbidge ◽  
K. Thompson ◽  
E. C. Firth ◽  
W. J. Bruce
Keyword(s):  
Articular Cartilage ◽  
Range Of Motion ◽  
Cartilage Repair ◽  
Articular Cartilage Repair ◽  
Cartilage Healing ◽  
Joint Range Of Motion ◽  
Cell Counts ◽  
Voluntary Motion ◽  
Joint Range

SummaryIn this study, articulated transarticular external skeletal fixators were used to examine the effects of joint immobilisation, twice-daily passive range-of-motion exercises, and voluntary motion on articular cartilage healing and other joint parameters. Abaxial articular cartilage lesions demonstrated superior cartilage healing to axial lesions. Twice-daily passive range of motion exercises failed to improve the quality of articular cartilage repair when compared with joint immobilisation. Voluntary motion resulted in superior articular cartilage repair tissue with maintenance of near normal cartilage architecture, proteoglycan staining, synovial fluid cell counts and specific gravity, and joint range-of-motion.

Comparison of disease-specific quality of life tools in patients with chronic venous disease

2013 ◽  
Vol 29 (10) ◽  
pp. 648-653 ◽  
Author(s):  
Mong-Loon Kuet ◽  
Tristan RA Lane ◽  
Muzaffar A Anwar ◽  
Alun H Davies
Keyword(s):  
Quality Of Life ◽  
Varicose Vein ◽  
Strong Correlation ◽  
Clinical Severity ◽  
Chronic Venous Disease ◽  
Venous Disease ◽  
Life Questionnaire ◽  
The Relationship ◽  
Disease Specific

Objectives This work was presented as a poster in the American Venous Forum 25th Annual Meeting; 28 February 2013; Phoenix, Arizona, USA. Quality of life (QoL) is an important outcome measure in the treatment for chronic venous disease. The Aberdeen Varicose Vein Questionnaire (AVVQ) and the ChronIc Venous Insufficiency quality of life Questionnaire (CIVIQ-14) are two validated disease-specific QoL questionnaires in current use. The aim of this study is to evaluate the relationship between the AVVQ and the CIVIQ-14 to enable better comparison between studies and to compare these disease-specific QoL tools with generic QoL and clinician-driven tools. Methods Adults attending our institution for management of their varicose veins completed the AVVQ, CIVIQ-14 and EuroQol-5D (EQ-5D). Clinical data, CEAP classification and the Venous Clinical Severity Score (VCSS) were collected. The relationship between the AVVQ and CIVIQ-14 scores was analysed using Spearman’s correlation. The AVVQ and CIVIQ-14 scores were also analysed with a generic QoL tool (EQ-5D) and a clinician-driven tool, the VCSS. Results One hundred patients, mean age 57.5 (44 males; 56 females), participated in the study. The median AVVQ score was 21.9 (range 0–74) and the median CIVIQ-14 score was 30 (range 0–89). A strong correlation was demonstrated between the AVVQ and CIVIQ-14 scores ( r = 0.8; p < 0.0001). Strong correlation was maintained for patients with C1-3 disease ( r = 0.7; p < 0.0001) and C4-6 disease ( r = 0.8; p < 0.0001). The VCSS correlated strongly with the AVVQ and CIVIQ-14 scores ( r = 0.7; p < 0.0001 and r = 0.7; p < 0.0001, respectively). Both the AVVQ and CIVIQ-14 scores correlated well with the EQ-5D score ( r = −0.5; p < 0.0001 and r = −0.7; p < 0.0001, respectively). Conclusions This study demonstrates that there is good correlation between two widely used varicose vein specific QoL tools (AVVQ and CIVIQ-14) across the whole spectrum of disease severity. Strong correlation exists between these disease-specific QoL tools and generic and clinician-driven tools. Our findings confirm valid comparisons between studies using either disease-specific QoL tool.

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