Changes in sleep predict changes in depressive symptoms in depressed subjects receiving vortioxetine: An open-label clinical trial

2019 ◽  
Vol 33 (11) ◽  
pp. 1388-1394 ◽  
Author(s):  
Bing Cao ◽  
Caroline Park ◽  
Joshua D Rosenblat ◽  
Yan Chen ◽  
Michelle Iacobucci ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Sleep Quality ◽  
Epworth Sleepiness Scale ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Severity Index ◽  
Major Depressive ◽  
Insomnia Severity Index ◽  
Insomnia Severity

Background Sleep disturbances are frequently reported in patients with major depressive disorder. We aimed to investigate the effects of vortioxetine on sleep quality and association between changes in sleep and treatment response. Methods: This study is a post-hoc analysis of a clinical trial that sought to evaluate the sensitivity to cognitive change of THINC-integrated tool in patients with major depressive disorder. In total, 92 patients (aged 18 to 65) meeting Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition criteria for moderate or severe major depressive disorder and 54 healthy controls were included. All patients received open-label vortioxetine (10–20 mg/day, flexibly dosed) for 8 weeks. Herein, the primary outcomes of interest were changes in sleep, as measured by the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Insomnia Severity Index, between weeks 0, 2, and 8. The association between changes in sleep and depressive symptom severity was secondarily assessed. Results: We observed that sleep, as indicated by scores of Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Insomnia Severity Index, was significantly poorer in patients with major depressive disorder compared to healthy controls at weeks 0, 2, and 8 ( p < 0.05). Among patients with major depressive disorder, we observed significant improvements on the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale and Insomnia Severity Index between weeks 0 and 8 ( p < 0.05). We observed a significant association between improvements on the Pittsburgh Sleep Quality Index, Epworth Sleepiness Scale, and Insomnia Severity Index and improvement of depressive symptoms. Conclusion: Improvement of depressive symptoms in major depressive disorder patients treated with vortioxetine was associated with significant improvements in sleep. Furthermore, improvements in sleep were predictive of antidepressant response and were linearly correlated with improvement in overall depressive symptom severity.

scholarly journals Baseline Sleep Dysfunction Among Matriculating Interns

2012 ◽  
Vol 4 (2) ◽  
pp. 202-208 ◽  
Author(s):  
Samantha J. Pulliam ◽  
Debra F. Weinstein ◽  
Atul Malhotra ◽  
Eric A. Macklin ◽  
Lori R. Berkowitz
Keyword(s):  
Sleep Quality ◽  
Daytime Sleepiness ◽  
Epworth Sleepiness Scale ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Severity Index ◽  
Sleep Habits ◽  
Insomnia Severity Index ◽  
Graduate Medical ◽  
Insomnia Severity

Abstract Background Work hour limitations for graduate medical trainees, motivated by concerns about patient safety, quality of care, and trainee well-being, continue to generate controversy. Little information about sleep habits and the prevalence of sleep disorders among residents is available to inform policy in this area. Objectives To evaluate the sleep habits of matriculating residents, postgraduate year-1 (PGY-1). Design An anonymous, voluntary, self-administered survey study was used with 3 validated questionnaires: the Pittsburgh Sleep Quality Index, the Insomnia Severity Index, and the Epworth Sleepiness Scale, which were fielded to PGY-1 residents entering the Accreditation Council for Graduate Medical Education–accredited programs at Massachusetts General Hospital and/or Brigham and Women's Hospitals in June and July 2009. Results Of 355 eligible subjects, 310 (87%) participated. Mean sleep time for PGY-1 residents was 7 hours and 34 minutes, and 5.6% of PGY-1 residents had Pittsburgh Sleep Quality Index global scores greater than 5, indicating poor quality sleep. Using multiple linear and ordinal logistic regression models, men had higher Pittsburgh Sleep Quality Index sleep latency scores, whereas women and those with children had higher Epworth Sleepiness Scale daytime sleepiness scores, and 18% of PGY-1 residents had abnormal amounts of daytime sleepiness based on the Epworth Sleepiness Scale. The Insomnia Severity Index identified 4.2% of PGY-1 residents with moderate insomnia. Conclusions Some PGY-1 residents may begin residency with sleep dysfunctions. Efforts to provide targeted help to selected trainees in managing fatigue during residency should be investigated.

scholarly journals Sleep in post-COVID-19 recovery period and its impact on different domains of quality of life

2021 ◽  
Vol 57 (1) ◽  
Author(s):  
Samir El Sayed ◽  
Sarah Gomaa ◽  
Doaa Shokry ◽  
Ahmed Kabil ◽  
Ahmed Eissa
Keyword(s):  
Quality Of Life ◽  
Sleep Quality ◽  
Quality Index ◽  
Pittsburgh Sleep Quality Index ◽  
Sleep Problems ◽  
Recovery Period ◽  
Severity Index ◽  
Insomnia Severity Index ◽  
Insomnia Severity

Abstract Background COVID-19 pandemic became a global health problem affecting the life of millions of people all over the world. The effects of this pandemic were not only on the physical and medical aspects but also on the psychological issues including anxiety disorders, depressive manifestations, sleep problems and others. Sleep disorders were very commonly reported during the novel Coronavirus-19 pandemic either in the acute phase of COVID-19 infection or after recovery. These sleep problems might have a drastic burden on the recovered patients’ life. This study aimed to investigate the sleep in the post-Coronavirus-19 period and if has an impact on the different items of patients’ quality of life. This cross-sectional observational study investigated the sleep problems in 500 patients in the post recovery period using Insomnia Severity Index and Pittsburgh sleep quality index (PSQI), their relation to this critical period and their impact on different domains of Quality of Life which was assessed by the SF36 Health Survey. Results Socio-demographic characteristics of 500 post-Coronavirus-19 patients were collected; the insomnia severity index and Pittsburgh sleep quality index evaluated the sleep pattern. The quality of life was investigated using Short Form 36 scale. The study revealed high scores of insomnia severity index (13.01 ± 4.9), Pittsburgh sleep quality index (15.37 ± 4.43), also high scores of different items of scale of quality of life in the studied group. Conclusion Post-COVID-19 sleep disturbances were commonly reported in the recovery period, also these sleep deficits had an impact on the physical and mental aspects of quality of life, so these sleep problems must be managed properly especially in this critical pandemic era.

Insomnio, TDAH y Patología Dual: estudio transversal en una muestra de 252 pacientes TDAH adultos

2020 ◽  
Author(s):  
Christian Fadeuilhe Grau ◽  
◽  
Vanesa Richarte Fernández ◽  
Montserrat Corrales de la Cruz ◽  
Raúl Felipe Palma-Álvarez ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Quality Index ◽  
Rating Scale ◽  
Pittsburgh Sleep Quality Index ◽  
Severity Index ◽  
Insomnia Severity Index ◽  
Uso De Sustancias ◽  
Dual Material ◽  
Insomnia Severity

Objetivos Identificar la prevalencia y evaluar las características clínicas del insomnio en una muestra de pacientes TDAH adultos con Patología Dual. Material y métodos La muestra la forman 252 pacientes adultos con TDAH remitidos para evaluación diagnóstica al Programa de TDAH del Hospital Universitari Vall d’Hebron. Se realizó una evaluación clínica y psicodiagnóstica, administrándose las escalas SCID-I y SCID-II, CAARS, ADHD Rating Scale y WURS. Igualmente se realizó una evaluación clínica del insomnio complementada con la administración de dos escalas específicas: la Insomnia Severity Index (ISI) y la Pittsburgh Sleep Quality Index (PSQI). Resultados y conclusiones La presencia de insomnio en pacientes adultos con TDAH presentaba una asociación estadísticamente significativa (11.6% vs. 4.3%; p<0.029) en aquellos pacientes que presentaban comórbidamente un Trastorno por uso de sustancias (alcohol, cocaína o cannabis). Esta asociación entre el insomnio y el TDAH adulto también fue identificada en aquellos pacientes adultos con antecedente de Trastorno por uso de sustancias (34.8% vs 15.0%; p<0.0001). Esta asociación era mayor en la presentación combinada del TDAH, observándose igualmente una correlación estadística entre la presencia de insomnio y la severidad clínica del TDAH.

scholarly journals Gut Microbiome Composition Associated With Major Depressive Disorder and Sleep Quality

2021 ◽  
Vol 12 ◽  
Author(s):  
Qi Zhang ◽  
Yajun Yun ◽  
Huimei An ◽  
Wenxuan Zhao ◽  
Ting Ma ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Gut Microbiota ◽  
Depressive Disorder ◽  
Sleep Quality ◽  
Critical Role ◽  
Depression Scale ◽  
Hamilton Depression Scale ◽  
Major Depressive ◽  
Severity Of Depression ◽  
Insomnia Severity

The microbiota–gut–brain axis plays a critical role in the pathogenesis of major depressive disorder (MDD) and related subclinical symptoms. However, studies on the gut microbiota in MDD are inconsistent, and data on MDD's effects on sleep are lacking. This study aimed to analyze the gut microbiota composition and sleep quality of patients with MDD. We performed 16S rRNA sequencing of stool samples from 36 patients with MDD and 45 healthy controls (HC). Sleep quality was assessed using the Pittsburgh Sleep Quality Index, depressive severity with the Hamilton Depression Scale, and insomnia severity using the Insomnia Severity Index. Forty-eight microbiota targets showed significant differences between MDD and HC. In MDD, six microbiota targets were associated with the severity of depression, 11 with sleep quality, and 3 with sleep severity. At the genus level, Dorea was simultaneously related to depression and sleep quality, while Intestinibacter was more closely related to sleep problems. Coprococcus and Intestinibacter were associated with sleep quality independent of the severity of depression. In conclusion, the present findings enable a better understanding of the relationship between gut microbiota and MDD-related symptoms. Gut microbiota alterations may become potential biomarkers and/or treatment targets for sleep quality in MDD.

EFFECT OF HIRUDOTHERAPY ON INSOMNIA DISORDERS AFTER A CORONAVIRUS INFECTION

2021 ◽  
pp. 48-51
Author(s):  
С.Ж. СЕРИКБАЕВА ◽  
Г.С. КАЙШИБАЕВА ◽  
Г.Б. АБАСОВА
Keyword(s):  
Sleep Quality ◽  
Epworth Sleepiness Scale ◽  
Severity Index ◽  
Average Score ◽  
Insomnia Severity Index ◽  
Average Value ◽  
Coronavirus Infection ◽  
Insomnia Severity ◽  
Objective Improvement

Индекс выраженности бессонницы (ISI) у больных после перенесенной коронавирусной инфекции составили 17,5±1,05, при норме 5,4±0,21, значение шкалы сонливости по Эпворту (ESS) 11,8±0,59 при норме 4,2±0,19 баллов. Индекс качества сна (PSQI), уменьшился и средний балл после пятикратного и 10дневного применения на 24,6 % и 46,5 % (р < 0,001), среднее значение по шкале оценки индекса выраженности бессонницы (ISI) и сонливости по Эпворту (ESS) у больных с ПКВИ уменьшилось после применения 10дневного курса гирудотерапии на 50,9 % и 42,4 %.Индекс выраженности инсомнических нарушений после пятикратного и 10дневного применения гирудотерапии снизились на 24,5% и 47% по сравнеию с исходными даннымиТаким образом, у больных с ПКВИ, принимавших 10дневный курс гирудотерапии, показали объективное улучшение у них инсомнических функций. The insomnia severity index (ISI) in patients after coronavirus infection was 17.5±1.05, with a norm of 5.4±0.21, the Epworth sleepiness scale (ESS) value was 11.8±0.59 with a norm of 4.2±0.19. The index of sleep quality (PSQI), the average score after 5day and 10day course of hirudotherapy decreased by 24,6% and 46,5% (p < 0,001), the average value of the insomnia severity index (ISI) and the Epworth sleepiness scale (ESS) in patients with PCVI decreased by 50,9% and 42,4% after 10day course of hirudotherapy.The index of insomnia disorders expression after 5 and 10day hirudotherapy decreased by 24,5% and 47% in comparison with the initial data.Thus, patients with PKVI who underwent hirudotherapy for 10 days showed objective improvement of insomniac functions.

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