Neural stem cell transplantation in ischemic stroke: A role for preconditioning and cellular engineering
2017 ◽
Vol 37
(7)
◽
pp. 2314-2319
◽
Keyword(s):
Ischemic stroke continues to be a leading cause of morbidity and mortality throughout the world. To protect and/or repair the ischemic brain, a multitiered approach may be centered on neural stem cell (NSC) transplantation. Transplanted NSCs exert beneficial effects not only via structural replacement, but also via immunomodulatory and/or neurotrophic actions. Unfortunately, the clinical translation of such promising therapies remains elusive, in part due to their limited persistence/survivability within the hostile ischemic microenvironment. Herein, we discuss current approaches for the development of NSCs more amenable to survival within the ischemic brain as a tool for future cellular therapies in stroke.
2019 ◽
Vol 11
(10)
◽
pp. 817-830
◽
2020 ◽
Vol 19
(7)
◽
pp. 2676-2688
◽
Keyword(s):
2010 ◽
Vol 30
(6)
◽
pp. 678-681
2013 ◽
Vol 32
(8)
◽
pp. 918-920
2006 ◽
Vol 142
(4)
◽
pp. 511-514
◽
2015 ◽
Vol 14
(4)
◽
pp. 17799-17808
◽
Keyword(s):
Keyword(s):