Vertebral bone marrow diffusivity in healthy adults at 3T diffusion-weighted imaging

2016 ◽  
Vol 57 (10) ◽  
pp. 1238-1243 ◽  
Author(s):  
He Jie ◽  
Fang Hao ◽  
Li Xiao Na
Keyword(s):  
Bone Marrow ◽  
Diffusion Weighted Imaging ◽  
Healthy Adults ◽  
Vertebral Bone ◽  
Diffusion Weighted ◽  
Vertebral Bone Marrow

Vertebral bone marrow diffusivity in normal adults with varying bone densities at 3T diffusion-weighted imaging

2017 ◽  
Vol 59 (1) ◽  
pp. 89-96 ◽  
Author(s):  
Jie He ◽  
Hao Fang ◽  
Xiao na Li
Keyword(s):  
Bone Marrow ◽  
Bone Density ◽  
Diffusion Weighted Imaging ◽  
Mineral Density ◽  
Vertebral Bone ◽  
Normal Bone ◽  
Diffusion Weighted ◽  
Adc Values ◽  
Vertebral Bone Marrow ◽  
Normal Adults

Background There has been controversy surrounding the relationship between diffusivity and bone mineral density (BMD) in vertebral bone marrow. Moreover, sex-related differences of vertebral bone marrow diffusivity in relation to varying bone densities have not yet been evaluated. Purpose To prospectively investigate the role of diffusion-weighted imaging (DWI) in assessing vertebral marrow changes in normal adults with varying bone densities. Material and Methods A total of 124 normal adult volunteers were enrolled in this study. Sagittal magnetic resonance (MR) DWI of the lumbar spine was performed. The ADC values of vertebral bone marrow were measured. Volumetric BMD measurement was performed by quantitative computed tomography (QCT) using Mindways QCT analysis software. All participants were divided into three groups according to BMD (normal, osteopenia, osteoporosis). The differences of the apparent diffusion coefficient (ADC) values of the three groups was compared, and partial correlation analysis was used to evaluate the correlation between ADC values and BMD. Results ADC values decreased as BMD decreased in female participants. When compared with the normal bone density group, ADC values were significantly decreased in the osteoporotic group and in the osteopenic group of female participants. ADC values of female participants were significantly higher than of male participants in the normal bone density group ( P < 0.001). ADC values correlated positively with BMD values (r = 0.307, P = 0.016) for female participants. Conclusion The diffusivity in vertebral bone marrow with varying bone densities differed by sex. ADC values correlated positively with BMD in women. DWI can quantitively evaluate osteoporosis in women.

Physiological uptake of 18F-FDG in the vertebral bone marrow in healthy adults on PET/CT imaging

2018 ◽  
Vol 59 (12) ◽  
pp. 1487-1493 ◽  
Author(s):  
Guohua Shen ◽  
Meng Liang ◽  
Minggang Su ◽  
Anren Kuang
Keyword(s):  
Bone Marrow ◽  
Vertebral Body ◽  
Cervical Vertebrae ◽  
Healthy Adults ◽  
Physiological Uptake ◽  
Vertebral Bone ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Vertebral Bone Marrow ◽  
18F Fdg

Background 18F-fluorodeoxyglucose *Equal contributors. positron emission tomography/computed tomography (18F-FDG PET/CT) has proven to be a valuable imaging modality for the assessment of bone marrow condition. Purpose To investigate the physiological uptake of 18F-FDG in the vertebral bone marrow in healthy adults on PET/CT imaging, and correlate the appearance with clinical factors including gender, body mass index, and age. Material and Methods A total of 64 healthy individuals underwent PET/CT scan, and for each vertebral body, the mean and maximum standardized uptake value (SUVmean and SUVmax) were determined in the central slice of vertebral body on the transversal fused PET/CT image. For each individual, the FDG uptake of the four regions was obtained by averaging the SUVmean and SUVmax of the vertebrae in individual regions. Results The FDG uptake from thoracic to sacral vertebrae showed an upward trend first, then a downward trend, while that of cervical vertebrae was relatively stable. The SUVmax and SUVmean values of bone marrow in the old group (age ≥ 50 years) were significantly lower than those in the young group (age < 50 years) in all regions of the spine ( P < 0.05). FDG uptake of the whole spine showed significant negative correlation with age, and the strongest correlation was observed in lumbar spine (SUVmean: r = −0.364, P < 0.05; SUVmax: r = −0.344, P < 0.05). Conclusion FDG uptake showed a tendency to increase first then decrease from thoracic to sacral vertebrae while the tendency was not obvious in cervical vertebrae. In addition, the glycolytic metabolism of all the four regions decreased with advancing age.

Evaluation of Vertebral Bone Marrow with Diffusion Weighted MRI and ADC Measurements

2014 ◽  
Author(s):  
Onder Turna ◽  
Mustafa Devran Aybar ◽  
Goksel Tuzcu ◽  
Yesim Karagoz ◽  
Ozgu Kesmezacar ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Diffusion Weighted Mri ◽  
Vertebral Bone ◽  
Diffusion Weighted ◽  
Vertebral Bone Marrow

Evaluation of Vertebral Bone Marrow with Diffusion Weighted MRI and ADC Measurements

2014 ◽  
Vol 15 (2) ◽  
pp. 116-121 ◽  
Author(s):  
Onder Turna ◽  
Mustafa Devran Aybar ◽  
Goksel Tuzcu ◽  
Yesim Karagoz ◽  
Ozgu Kesmezacar ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Diffusion Weighted Mri ◽  
Vertebral Bone ◽  
Diffusion Weighted ◽  
Vertebral Bone Marrow

Age- and sex-related differences in vertebral bone marrow fat content in healthy adults from east China

2020 ◽  
Author(s):  
qingping Li ◽  
shaoqing Chen ◽  
panpan Zhou ◽  
anna Guo ◽  
peipei Ye ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Age Groups ◽  
Fat Content ◽  
Healthy Adults ◽  
Marrow Fat ◽  
Men And Women ◽  
Vertebral Bone ◽  
Bone Marrow Fat ◽  
Fat Composition ◽  
Vertebral Bone Marrow

Abstract Background Bone-marrow water–fat composition is a useful imaging biomarker. However, the vertebral bone-marrow fat composition in healthy adults of east China is unknown. The aim of this study was to investigate differences in lumbar vertebral bone-marrow fat content between the sexes with age, using iterative decomposition of water and fat with echo asymmetry and least-squares estimation quantitation (IDEAL-IQ). Methods Three-hundred-and-twenty-one healthy volunteers (age range 20–29 years: 32/33 men/women; 30–39 years: 40/37; 40–49 years: 21/45; 50–59 years: 26/37; ≥ 60 years: 15/26) were included in the present study. All subjects underwent IDEAL-IQ sequence imaging on a 3.0-T MR scanner. Bone-marrow fat-fraction ratio (FF%) was calculated for each vertebral body from sagittal lumbar images. Men and women were compared within age-groups by independent-samples t -tests, and different age-groups and vertebral segments were compared by Bonferroni post-hoc test. FF% correlations with age and body mass index (BMI) were analyzed with Spearman’s correlation coefficient. FF% and vertebral segment correlations were assessed by partial correlation analysis, after adjustment for sex and age. Results FF% averaged over L1–L5 was significantly higher in men than in women for the < 40-year age-groups ( P = 0.000). Bone-marrow fatty conversion was accelerated in women compared to men aged 40–49 years, but was similar in women and men aged > 60 years ( P > 0.05). FF% correlation with age was weakly positive in men ( r = 0.253, P = 0.003), and moderately positive in women ( r = 0.581, P < 0.001), but was non-significantly correlated with BMI and vertebral segments ( r = 0.218; r = 0.187, respectively). FF% was higher in the lower than in the upper lumbar segments ( P < 0.05). Conclusion IDEAL-IQ can accurately quantify lumbar bone-marrow fat infiltration. This increases with age, and differs between men and women and between lower and upper lumbar segments.

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