Kinin Activation as a Predictive Assay for Adverse Reactions to Radiographic Contrast Medium

1984 ◽  
Vol 25 (4) ◽  
pp. 337-342 ◽  
Author(s):  
D. H. Carr ◽  
A. C. Walker

The rate of conversion in vitro, of prekallikrein to kallikrein has been measured in 74 reactors to contrast medium and 70 controls. The conversion rate is significantly more rapid in reactors than controls. There was no difference in C1-esterase inhibitor and factor XII levels between reactors and controls. This retrospective investigation suggests that prekallikrein/kallikrein conversion rate may form the basis of a test for differentiating between reactors and non-reactors.

2015 ◽  
Vol 56 (6) ◽  
pp. 702-708 ◽  
Author(s):  
Karoline Meurer ◽  
Michael Laniado ◽  
Norbert Hosten ◽  
Bettina Kelsch ◽  
Barry Hogstrom

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Muhamad Idham Mohamed ◽  
Mohd Khairul Amran Mohammad ◽  
Hairil Rashmizal Abdul Razak ◽  
Khairunisak Abdul Razak ◽  
Wan Mazlina Md Saad

Emerging syntheses and findings of new metallic nanoparticles (MNPs) have become an important aspect in various fields including diagnostic imaging. To date, iodine has been utilized as a radiographic contrast medium. However, the raise concern of iodine threats on iodine-intolerance patient has led to search of new contrast media with lower toxic level. In this animal modeling study, 14 nm iron oxide nanoparticles (IONPs) with silane-polyethylene glycol (SiPEG) and perchloric acid have been assessed for toxicity level as compared to conventional iodine. The nanotoxicity of IONPs was evaluated in liver biochemistry, reactive oxygen species production (ROS), lipid peroxidation mechanism, and ultrastructural evaluation using transmission electron microscope (TEM). The hematological analysis and liver function test (LFT) revealed that most of the liver enzymes were significantly higher in iodine-administered group as compared to those in normal and IONPs groupsP<0.05. ROS production assay and lipid peroxidation indicator, malondialdehyde (MDA), also showed significant reductions in comparison with iodine groupP<0.05. TEM evaluation yielded the aberration of nucleus structure of iodine-administered group as compared to those in control and IONPs groups. This study has demonstrated the less toxic properties of IONPs and it may postulate that IONPs are safe to be applied as radiographic contrast medium.


1987 ◽  
Vol 28 (5) ◽  
pp. 601-602
Author(s):  
A. Alanen ◽  
P. Nummi ◽  
M. Kormano ◽  
K. Irjala

Relaxation times Tl of normal and abnormal urine samples were measured with a 0.02 tesla MRI device in a spectrometric mode. Protein containing urine from patients with glomerulonephritis showed a slight shortening of Tl relaxation time. Radiographic contrast medium, pH, osmolality or glucose in diabetes did not significantly change the Tl relaxation time of urine. Urine can be used as a T1 relaxation reference in MR imaging of the pelvis even if the patient has received radiographic contrast medium or has diabetes or proteinuria for any reason.


1991 ◽  
Vol 84 (1) ◽  
pp. 92-94 ◽  
Author(s):  
CONSTANCE A. JENNINGS ◽  
JOHN DEVEIKIS ◽  
NORIO AZUMI ◽  
HENRY YEAGER

1974 ◽  
Vol 41 (6) ◽  
pp. 688-690
Author(s):  
Edward B. Silberstein ◽  
Alan B. Ashare

✓ The authors report examination of 27 brain scintigraphs performed 1 day following cerebral angiography, and 48 performed within 2 weeks. No artifactual areas of uptake were produced in the scintigraphs by the radiographic contrast medium.


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