scholarly journals Could neutrophil/lymphocyte ratio be an indicator of coronary artery disease, coronary artery ectasia and coronary slow flow?

2016 ◽  
Vol 44 (6) ◽  
pp. 1443-1453 ◽  
Author(s):  
Mücahid Yılmaz ◽  
Hasan Korkmaz ◽  
Mehmet Nail Bilen ◽  
Ökkeş Uku ◽  
Ertuğrul Kurtoğlu
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Slow Flow ◽  
Coronary Artery Ectasia ◽  
Operating Characteristics ◽  
Coronary Anatomy ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Coronary Slow Flow ◽  
Artery Disease

Objective To determine whether neutrophil/lymphocyte ratio (NLR) differed between patients with isolated coronary artery disease (CAD), isolated coronary artery ectasia (CAE), coronary slow flow and normal coronary anatomy. Methods Patients who underwent coronary angiography were consecutively enrolled into one of four groups: CAD, coronary slow flow, CAE and normal coronary anatomy. Results The CAD ( n = 40), coronary slow flow ( n = 40), and CAE ( n = 40) groups had similar NLRs (2.51 ± 0.7, 2.40 ± 0.8, 2.6 ± 0.6, respectively) that were significantly higher than patients with normal coronary anatomy ( n = 40; NLR, 1.73 ± 0.7). Receiver operating characteristics demonstrated that with NLR > 2.12, specificity in predicting isolated CAD was 85% and sensitivity was 75%, with NLR > 2.22 specificity in predicting isolated CAE was 86% and sensitivity was 75%. With NLR > 1.92, specificity in predicting coronary slow flow was 89% and sensitivity was 75%. Multivariate logistic regression analyses identified NLR as an independent predictor of isolated CAE (β = −0.499, 95% CI −0.502, −0.178; P <  0.001), CAD (β = −0.426, 95% CI −1.321, −0.408; P <  0.001), and coronary slow flow (β = −0.430, 95% CI −0.811, −0.240; P = 0.001 Table 2 ). Conclusions NLR was higher in patients with CAD, coronary slow flow and CAE versus normal coronary anatomy. NLR may be an indicator of CAD, CAE and coronary slow flow.

scholarly journals Atherosclerosis Is Associated with Neutrophil Lymphocyte Ratio As An Inflammatory Marker in Type 2 Diabetes Mellitus Patients with Coronary Artery Disease

2016 ◽  
Vol 24 (1) ◽  
pp. 24-29
Author(s):  
Mohammad Monzurul Alam Bhuiyan ◽  
Tuhin Sultana ◽  
Md Saiful Islam ◽  
Dhiman Borua ◽  
Mostaque Ahmed ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Coronary Angiography ◽  
Inflammatory Marker ◽  
Clinical Pathology ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Type 2 Dm ◽  
Artery Disease

Background: Increased neutrophil lymphocyte ratio is associated with major adverse outcomes of cardiac events in type 2 diabetes mellitus (DM) patients.Objective: To assess the NLR as an inflammatory marker in atherosclerosis in type 2 DM patients with coronary artery disease (CAD).Methods: This case control study was conducted in the Department of Clinical Pathology in collaboration with Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2014 to February 2015. Total 134 patients were enrolled in this study who were waiting for coronary angiography in the Department of Cardiology, BSMMU; 84 cases were considered as Group I (DM with CAD) and 50 controls were Group II (DM without CAD). A 2 ml of blood was collected in EDTA tube from the patients prior to coronary angiogram for complete blood count (CBC) were measured by haematology autoanalyzer, rechecked manually and NLR was calculated in the Department of Clinical Pathology, BSMMU. Coronary artery disease with 50% coronary artery stenosis and more critical lesion that were diagnosed by coronary angiography were included in this study as cases. Coronary artery disease with less than 50% coronary artery stenosis that was diagnosed by coronary angiography was included in this study as control.Results: NLR was higher in CAD positive group compared to group without CAD negative in type 2 DM patients (2.76 (±0.74) vs. 1.56 (±0.15), p<0.001).Conclusion: With the help of neutrophil lymphocyte ratio we can take preventive measure and precaution to reduce the progression of atherosclerosis in type 2 diabetic patients with coronary artery disease.J Dhaka Medical College, Vol. 24, No.1, April, 2015, Page 24-29

scholarly journals Comparison of Tumor Necrosis Factor-α Level in Coronary Artery Disease and Coronary Slow Flow of Thrombolysis in Myocardial Infarction

2019 ◽  
Vol 11 (3) ◽  
pp. 299-303
Author(s):  
Muhammad Diah ◽  
Rahmawati Rahmawati ◽  
Aznan Lelo ◽  
Zulfikri Muhktar ◽  
Dharma Lindarto ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Healthy Subjects ◽  
Slow Flow ◽  
Timi Frame Count ◽  
Tnf Α ◽  
Significant Difference ◽  
Coronary Slow Flow ◽  
Artery Disease ◽  
Α Level

BACKGROUND: Tumor necrosis factor (TNF)-α, an important primary pro-inflammatory cytokine, has a crucial role in the pathogenesis of atherosclerosis. Since the pathophysiological mechanism of coronary slow flow (CSF) is not fully understood, we investigated the level of TNF-α in coronary artery disease (CAD), CSF and healthy subjects.METHODS: This study was conducted in cross-sectional design involving 16 CAD, 18 CSF and 18 healthy subjects. Coronary angiography was recorded at the left anterior oblique, cranial, right anterior oblique, caudal, and horizontal positions. The flow in coronary arteries of the subjects were assessed using Thrombolysis in the Myocardial Infarction (TIMI) frame count method. Peripheral blood-derived serum was collected and level of TNF-α was determined by using highly sensitive enzymelinked immunosorbent assay (ELISA).RESULTS: No significant difference in level of TNF-α in CAD, CSF and healthy subjects (2.72±2.64 pg/mL, 1.88±0.8 pg/mL, 1.64±0.35 pg/mL, respectively) (p=0.087). In addition, there was no correlation between the concentration of TNF-α and TIMI frame count (r<0.2, p>0.05).CONCLUSION: There was no significant difference of TNF-α level in CAD, CSF and healthy subjects. In addition, there was no correlation between the TNF-α level with TIMI frame count as well. Nevertheless, further clinical studies with more subjects are needed.KEYWORDS: TNF-alpha, coronary artery disease, coronary slow flow 

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