scholarly journals The rs10229583 polymorphism near paired box gene 4 is associated with gestational diabetes mellitus in Chinese women

2017 ◽  
Vol 46 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Tianyi Xu ◽  
Yiru Shi ◽  
Jiangbo Liu ◽  
Yun Liu ◽  
Ailin Zhu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Chinese Women ◽  
Insulin Response ◽  
High Blood Glucose ◽  
Genotype Frequencies ◽  
Pancreatic Islet Beta Cells ◽  
Gene 4

Objective The rs10229583 polymorphism near paired box gene 4 ( PAX4) is associated with insulin resistance and type 2 diabetes. Mutations in the PAX4 gene may be associated with impaired differentiation/development of pancreatic islet beta cells during fetal development and, consequently, a compromised insulin response to high blood glucose. To ascertain whether this polymorphism plays a role in gestational diabetes mellitus (GDM), we investigated the genotypic and allele frequency differences between GDM and normal pregnancies. Methods A total of 310 GDM and 440 normal pregnancies were evaluated. Allele and genotype frequencies of rs10229583 were determined for all participants with Sanger sequencing and SNaPshot. Association of the allele and genotypes of the single nucleotide polymorphism with the disease was analyzed using Pearson’s χ2 test and OR (odds ratio). Results The G allele was more frequent in patients with GDM compared with controls (OR = 1.47, 95% confidence interval (CI): 1.12–1.939). The GG genotype frequency of rs10229583 was significantly different between subjects with GDM and normal controls (OR = 1.411, 95% CI: 1.032–1.928). The OR of the GA +  GG genotype was 3.182 (95% CI: 1.294–7.826) for patients with GDM compared with controls. Conclusion The present study suggests that rs10229583 is associated with GDM.

scholarly journals Polymorphisms of TGF-β1 and TGF-β3 in Chinese Women With Gestational Diabetes Mellitus

2020 ◽  
Author(s):  
Yinglei Xu ◽  
Chunlian Wei ◽  
Cuijiao Wu ◽  
Mengmeng Han ◽  
Jingli Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Transforming Growth Factor ◽  
Chinese Women ◽  
Transforming Growth Factor Β ◽  
Allelic Discrimination ◽  
Genotype Frequencies ◽  
Increased Risk ◽  
Tgf Β1

Abstract Background: Gestational diabetes mellitus (GDM) is a pregnancy-specific carbohydrate intolerance Which can cause a large number of perinatal and postpartum complications. The members of Transforming growth factor-β (TGF-β) superfamily play key roles in the homeostasis of pancreatic β-cell and may involve in the development of GDM. This study aimed to explore the association between the polymorphisms of TGF-β1 , TGF-β3 and the risk to GDM in Chinese women.Methods: This study included 919 GDM patients(464 with preeclampsia and 455 without preeclampsia) and 1177 healthy pregnant women. TaqMan allelic discrimination real-Time PCR was used to genotyped the TGF-β1 (rs4803455) and TGF-β3 (rs2284792 and rs3917201) were by, The Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test.Results: An increased frequency of TGF-β3 rs2284792 AA and AG genotype carriers was founded in GDM patients (AA vs. AG+GG: χ²=6.314, P=0.012, OR=1.270, 95%CI 1.054-1.530; AG vs. GG+AA: χ²=8.545, P=0.003, OR=0.773, 95%CI 0.650-0.919). But there were no significant differences in the distribution of TGF-β1 rs4803455 and TGF-β3 rs3917201 between GDM and healthy women. And no significant differences were found in allele and genotype frequencies among GDM patients with preeclampsia (PE). Conclusions: The AA and AG genotype of TGF-β3 rs2284792 polymorphism may be significantly associated with increased risk of GDM in Chinese population.

scholarly journals Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with Gestational Diabetes Mellitus

2020 ◽  
Author(s):  
Yinglei Xu ◽  
Chunlian Wei ◽  
Cuijiao Wu ◽  
Mengmeng Han ◽  
Jingli Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Transforming Growth Factor ◽  
Chinese Women ◽  
Transforming Growth Factor Β ◽  
Allelic Discrimination ◽  
Genotype Frequencies ◽  
Increased Risk ◽  
Tgf Β1

Abstract Background: Gestational diabetes mellitus (GDM) is a pregnancy-specific carbohydrate intolerance Which can cause a large number of perinatal and postpartum complications. The members of Transforming growth factor-β (TGF-β) superfamily play key roles in the homeostasis of pancreatic β-cell and may involve in the development of GDM. This study aimed to explore the association between the polymorphisms of TGF-β1, TGF-β3 and the risk to GDM in Chinese women.Methods: This study included 919 GDM patients (464 with preeclampsia and 455 without preeclampsia) and 1177 healthy pregnant women. TaqMan allelic discrimination real-Time PCR was used to genotype the TGF-β1 (rs4803455) and TGF-β3 (rs2284792 and rs3917201), The Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test.Results: An increased frequency of TGF-β3 rs2284792 AA and AG genotype carriers was founded in GDM patients (AA vs. AG+GG: χ²=6.314, P=0.012, OR=1.270, 95%CI 1.054-1.530; AG vs. GG+AA: χ²=8.545, P=0.003, OR=0.773, 95%CI 0.650-0.919). But there were no significant differences in the distribution of TGF-β1 rs4803455 and TGF-β3 rs3917201 between GDM and healthy women. In addition, no significant differences were found in allele and genotype frequencies among GDM patients with preeclampsia (PE).Conclusions: The AA and AG genotype of TGF-β3 rs2284792 polymorphism may be significantly associated with increased risk of GDM in Chinese population.

scholarly journals Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with Gestational Diabetes Mellitus

2020 ◽  
Author(s):  
Yinglei Xu ◽  
Chunlian Wei ◽  
Cuijiao Wu ◽  
Mengmeng Han ◽  
Jingli Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Transforming Growth Factor ◽  
Chinese Women ◽  
Transforming Growth Factor Β ◽  
Allelic Discrimination ◽  
Genotype Frequencies ◽  
Increased Risk ◽  
Tgf Β1

Abstract Background: Gestational diabetes mellitus (GDM) is a pregnancy-specific carbohydrate intolerance Which can cause a large number of perinatal and postpartum complications. The members of Transforming growth factor-β (TGF-β) superfamily play key roles in the homeostasis of pancreatic β-cell and may involve in the development of GDM. This study aimed to explore the association between the polymorphisms of TGF-β1, TGF-β3 and the risk to GDM in Chinese women.Methods: This study included 919 GDM patients (464 with preeclampsia and 455 without preeclampsia) and 1177 healthy pregnant women. TaqMan allelic discrimination real-Time PCR was used to genotype the TGF-β1 (rs4803455) and TGF-β3 (rs2284792 and rs3917201), The Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test.Results: An increased frequency of TGF-β3 rs2284792 AA and AG genotype carriers was founded in GDM patients (AA vs. AG+GG: χ²=6.314, P=0.012, OR=1.270, 95%CI 1.054-1.530; AG vs. GG+AA: χ²=8.545, P=0.003, OR=0.773, 95%CI 0.650-0.919). But there were no significant differences in the distribution of TGF-β1 rs4803455 and TGF-β3 rs3917201 between GDM and healthy women. In addition, no significant differences were found in allele and genotype frequencies among GDM patients with preeclampsia (PE).Conclusions: The AA and AG genotype of TGF-β3 rs2284792 polymorphism may be significantly associated with increased risk of GDM in Chinese population.

scholarly journals Nomograms for incident risk of post-partum type 2 diabetes in Chinese women with prior gestational diabetes mellitus

2018 ◽  
Vol 90 (3) ◽  
pp. 417-424 ◽  
Author(s):  
Weiqin Li ◽  
Junhong Leng ◽  
Huikun Liu ◽  
Shuang Zhang ◽  
Leishen Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Chinese Women ◽  
Post Partum

scholarly journals Polymorphisms of TGF-β1 and TGF-β3 in Chinese women with gestational diabetes mellitus

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Yinglei Xu ◽  
Chunlian Wei ◽  
Cuijiao Wu ◽  
Mengmeng Han ◽  
Jingli Wang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Transforming Growth Factor ◽  
Chinese Women ◽  
Transforming Growth Factor Β ◽  
Allelic Discrimination ◽  
Genotype Frequencies ◽  
Increased Risk ◽  
Tgf Β1

Abstract Background Gestational diabetes mellitus (GDM) is a pregnancy-specific carbohydrate intolerance Which can cause a large number of perinatal and postpartum complications. The members of Transforming growth factor-β (TGF-β) superfamily play key roles in the homeostasis of pancreatic β-cell and may involve in the development of GDM. This study aimed to explore the association between the polymorphisms of TGF-β1, TGF-β3 and the risk to GDM in Chinese women. Methods This study included 919 GDM patients (464 with preeclampsia and 455 without preeclampsia) and 1177 healthy pregnant women. TaqMan allelic discrimination real-Time PCR was used to genotype the TGF-β1 (rs4803455) and TGF-β3 (rs2284792 and rs3917201), The Hardy-Weinberg equilibrium (HWE) was evaluated by chi-square test. Results An increased frequency of TGF-β3 rs2284792 AA and AG genotype carriers was founded in GDM patients (AA vs. AG + GG: χ2 = 6.314, P = 0.012, OR = 1.270, 95%CI 1.054–1.530; AG vs. GG + AA: χ2 = 8.545, P = 0.003, OR = 0.773, 95%CI 0.650–0.919). But there were no significant differences in the distribution of TGF-β1 rs4803455 and TGF-β3 rs3917201 between GDM and healthy women. In addition, no significant differences were found in allele and genotype frequencies among GDM patients with preeclampsia (PE). Conclusions The AA and AG genotype of TGF-β3 rs2284792 polymorphism may be significantly associated with increased risk of GDM in Chinese population.

scholarly journals Lactation Duration and Long-term Risk for Incident Type 2 Diabetes in Women With a History of Gestational Diabetes Mellitus

Diabetes Care ◽  
2020 ◽  
Vol 43 (4) ◽  
pp. 793-798 ◽  
Author(s):  
Sylvia H. Ley ◽  
Jorge E. Chavarro ◽  
Mengying Li ◽  
Wei Bao ◽  
Stefanie N. Hinkle ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Incident Type ◽  
Incident Type 2 Diabetes ◽  
History Of ◽  
Lactation Duration
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