scholarly journals Comparative study of assisted reproductive outcomes between young patients with occult premature ovarian insufficiency and advanced-age patients

2020 ◽  
Vol 48 (6) ◽  
pp. 030006052093465
Author(s):  
Ling-nv Yao ◽  
Wen-qin Lin ◽  
Nan Jiang ◽  
Chuyan Li ◽  
Hai-feng Cao ◽  
...  
Keyword(s):  
Live Birth ◽  
Ovarian Reserve ◽  
Embryo Implantation ◽  
Young Patients ◽  
Abortion Rate ◽  
Advanced Age ◽  
Premature Ovarian Insufficiency ◽  
Ovarian Insufficiency ◽  
Vitro Fertilization

Objective The purpose of this study was to compare the pregnancy outcomes among young patients with occult premature ovarian insufficiency (OPOI), advanced-age patients with diminished ovarian reserve (DOR), and advanced-age patients with normal ovarian reserve. Methods We retrospectively reviewed 324 women who underwent their first cycles of in vitro fertilization/intracytoplasmic sperm injection. The women were divided into the following groups: young women with OPOI, advanced-age women with DOR, and advanced-age women with normal ovarian reserve. The outcomes were compared among the different groups: Results The rates of live birth and embryo implantation in the young OPOI group were significantly higher than in the advanced-age DOR group, but comparable to those in the advanced-age normal ovarian reserve group. Moreover, the abortion rate was significantly lower in young OPOI patients compared with advanced-age patients with or without DOR. Conclusion Higher embryo implantation and live birth rates and a lower abortion rate can be achieved in young patients with OPOI compared with older patients. The better outcomes in advanced-age patients with normal ovarian reserve compared with DOR may be related to egg quantity rather than quality.

The value of Anti-Müllerian hormone in low and extremely low ovarian reserve in relation to live birth after in vitro fertilization

2016 ◽  
Vol 200 ◽  
pp. 45-50 ◽  
Author(s):  
Igna F. Reijnders ◽  
Willianne L.D.M. Nelen ◽  
Joanna IntHout ◽  
Antonius E. van Herwaarden ◽  
Didi D.M. Braat ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Ovarian Reserve ◽  
Vitro Fertilization

scholarly journals Ovarian Fragmentation and AKT Stimulation for Expansion of Fertile Lifespan

2021 ◽  
Vol 3 ◽  
Author(s):  
Kim Cat Tuyen Vo ◽  
Kazuhiro Kawamura
Keyword(s):  
Ovarian Reserve ◽  
Enzyme Inhibitor ◽  
Premature Ovarian Insufficiency ◽  
Hippo Signaling ◽  
Follicle Growth ◽  
Ovarian Insufficiency ◽  
Phosphatase And Tensin Homolog ◽  
Primordial Follicles ◽  
Tensin Homolog

Since the first baby was born after in vitro fertilization, the female infertility treatment has been well-developed, yielding successful outcomes. However, successful pregnancies for patients with premature ovarian insufficiency and diminished ovarian reserve are still difficult and diverse therapies have been suggested to improve the chances to have their genetically linked offspring. Recent studies demonstrated that the activation Akt pathway by using a phosphatase and tensin homolog enzyme inhibitor and a phosphatidylinositol-3 kinase stimulator can activate dormant primordial follicles in both mice and human ovaries. Subsequent researches suggested that the disruption of Hippo signaling pathway by ovarian fragmentation increased the expression of downstream growth factors and secondary follicle growth. Based on the combination of ovarian fragmentation and Akt stimulation, the in vitro activation (IVA) approach has resulted in successful follicle growth and live births in premature ovarian insufficiency patients. The approach with disruption of Hippo signaling only was also shown to be effective for treating poor ovarian responders with diminishing ovarian reserve, including advanced age women and cancer patients undergoing sterilizing treatments. This review aims to summarize the effectiveness of ovarian fragmentation and Akt stimulation on follicle growth and the potential of IVA in extending female fertile lifespan.

scholarly journals Interleukin-3 Polymorphism is Associated with Miscarriage of Fresh in Vitro Fertilization Cycles

2019 ◽  
Vol 16 (6) ◽  
pp. 995 ◽  
Author(s):  
Cheng-Hsuan Wu ◽  
Tsung-Hsien Lee ◽  
Shun-Fa Yang ◽  
Hui-Mei Tsao ◽  
Yu-Jun Chang ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Live Birth ◽  
Cohort Analysis ◽  
Embryo Implantation ◽  
Clinical Pregnancy ◽  
Birth Rates ◽  
Vitro Fertilization ◽  
Live Birth Rates ◽  
Increased Risk

The aim of this study was to examine the association between interleukin (IL) genes polymorphisms and in vitro fertilization (IVF) outcome. A prospective cohort analysis was performed at a Women’s Hospital IVF centre of 1015 female patients undergoing fresh non-donor IVF cycles. The effects of the following six single nucleotide polymorphisms (SNPs) in five IL genes on IVF outcomes were explored: IL-1α (rs1800587 C/T), IL-3 (rs40401 C/T), IL-6 (rs1800795 C/G), IL-15 (rs3806798 A/T), IL-18 (rs187238 C/G) and IL-18 (rs1946518 G/T). The main outcome measures included clinical pregnancy, embryo implantation, abortion and live birth rates. There were no statistically significant differences in clinical pregnancy, embryo implantation and live birth rates in the analysis of 1015 patients attempting their first cycle of IVF. Infertile women with IL-3 homozygous major genotype had a higher abortion rate than those with heterozygous and homozygous minor genotype (16.5% vs. 7.9%, P = 0.025). In conclusion, our results indicated that the IL-3 rs40401 polymorphism is associated with increased risk of abortion of IVF patients. Future studies with inclusion of other ethnic populations must be conducted to confirm the findings of this study.

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