Slow-wave sleep is associated with incident hypertension in patients with obstructive sleep apnea: a cross-sectional study

Objective This study aimed to examine the association between slow-wave sleep ([SWS] N3 stage) and the risk of hypertension in patients with obstructive sleep apnea (OSA) or primary snorers. Methods A retrospective cross-sectional study of 1145 participants who were evaluated for suspected OSA at our Sleep Medical Center were included. Among these participants, 1022 had OSA and 123 were primary snorers. Logistic regression modeling was performed to evaluate the association between the prevalence of hypertension and combined OSA and SWS based on polysomnographic measurements. Results Patients with OSA in the lowest SWS quartile (quartile 1, < 2.0%) showed a two-fold increased risk of hypertension after adjustment for confounding factors compared with primary snorers (odds ratio, 2.13 [95% confidence interval 1.54–2.06]). In logistic analysis stratified according to SWS quartiles, there was no significant difference in the risk of hypertension between patients with OSA and primary snorers in quartile 1. However, in the highest quartile (quartile 4), SWS was significantly associated with incident hypertension in patients with OSA rather than primary snorers. Conclusion SWS is associated with prevalent hypertension in patients with OSA. Notably, a low proportion of SWS confers a stronger association with incident hypertension than OSA.

Download Full-text

The Association Between Obstructive Sleep Apnea and Periodontitis in Chinese Male Adults: A Cross-Sectional Study

10.21203/rs.3.rs-56724/v1 ◽

2020 ◽

Author(s):

Yanlong Chen ◽

Ying Duan ◽

Yan Li ◽

Xiaoxia Han ◽

He Gao ◽

...

Keyword(s):

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Cross Sectional Study ◽

Apnea Hypopnea Index ◽

Sectional Study ◽

Cross Sectional ◽

Periodontal Tissues ◽

Obstructive Sleep ◽

Significant Difference ◽

Chinese Male

Abstract Background: Obstructive sleep apnea (OSA) is characterized by complete or partial upper airway obstruction during sleep. Periodontitis is an infectious and inflammatory disease of periodontal tissues. Recent studies suggested that both diseases could alter the host response synergistically by sharing same inflammatory pathways. The study aimed to investigate the association between OSA and periodontitis in Chinese male adults.Methods: This was a cross-sectional study of 93 male adults recruited from a dormitory compound and examined between June and September 2019. All participants were diagnosed OSA using the apnea–hypopnea index (AHI) with a portable, overnight polysomnography (PSG). Periodontal examinations were conducted the same day before PSG measuring: 1) mean probing depth (PD); 2) mean clinical attachment level (CAL); and 3) percentage of sites with bleeding on probing (BOP). An objective nasal airway resistance assessment was also practiced before PSG to reflect on the mouth breathing during sleep.Results: In all, 43.0% participants had periodontitis, 20.4% had OSA and 32.5% of those diagnosed with periodontitis were in combination with OSA. OSA was positively associated with periodontitis (odds ratio (OR) = 3.77, 95% confidence interval (CI) = 1.29 ~ 11.07). The OSA group showed a significantly higher BOP (p = 0.034) and CAL (p = 0.046), but there was no statistically significant difference of PD (p = 0.090) between the two groups. Correlation analysis showed a low but positive correlation between OSA severity and periodontitis severity classifications and periodontal parameters. Further regression analysis identified Lowest oxygen saturation (SaO2) (OR = 0.894, 95% CI = 0.842 ~ 0.949) to be significantly associated with the prevalence of periodontitis.Conclusions: A significant association was observed between OSA and periodontitis. And increasingly severe OSA might increase the severity of periodontitis. Hypoxia parameters might have a predicting effect of periodontitis, suggesting hypoxia related systematic inflammation may be the possible explanation of the association.

Download Full-text