Severe acitretin-induced diffuse idiopathic skeletal hyperostosis: a case report

Diffuse idiopathic skeletal hyperostosis (DISH), also known as Forestier–Rotes–Querol disease, is a systemic noninflammatory disease characterized by ossification of the entheses. DISH predominantly affects the spine. Although peripheral involvement is also often reported, it rarely affects patients’ function. A 77-year-old man presented to our emergency department because of incapacitating pain and stiffness in the spine and hips. The patient had been diagnosed with biopsy-proven mycosis fungoides 3 years earlier and had been treated with oral acitretin at 25 to 50 mg daily since diagnosis. However, the patient gradually developed a severely limited range of motion in his spine and hips (left > right), significantly impairing his mobility and activities of daily living. Cervical and dorsolumbar radiographs showed extensive ossification along the anterior longitudinal ligament; this finding was compatible with DISH and had not been present in radiographs taken 3 years earlier. Pelvic radiographs showed multiple enthesophytes predominantly around the coxofemoral joints. DISH has been reported as a possible long-term adverse effect of acitretin. Despite optimal conservative treatment, the patient remained severely impaired and thus finally underwent extensive osteophyte excision and total hip replacement on the left side. His acitretin therapy was also stopped to prevent further progression of his DISH.

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Lymphoedema in patients with lentigo maligna treated with imiquimod: a long-term adverse effect

British Journal of Dermatology ◽

10.1111/bjd.16267 ◽

2018 ◽

Vol 178 (6) ◽

pp. 1441-1442 ◽

Cited By ~ 2

Author(s):

D. Tio ◽

G. Kirtschig ◽

R. Hoekzema ◽

C. van Montfrans

Keyword(s):

Adverse Effect ◽

Lentigo Maligna ◽

Term Adverse Effect

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Long-term adverse effect of Kawasaki syndrome: Two- vessel coronary artery by-pass surgery for coronary artery aneurysm in a 16-year old male patient

Anadolu Kardiyoloji Dergisi/The Anatolian Journal of Cardiology ◽

10.5152/akd.2012.117 ◽

2012 ◽

Author(s):

Servet Altay ◽

Huseyin Altug Cakmak ◽

Hatice Betul Erer ◽

Mehmet Eren

Keyword(s):

Adverse Effect ◽

Coronary Artery ◽

Male Patient ◽

Coronary Artery Aneurysm ◽

Artery Aneurysm ◽

Kawasaki Syndrome ◽

Term Adverse Effect ◽

Vessel Coronary Artery

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Is Longstanding Congenital Muscular Torticollis Provoking Pelvic Malalignment Syndrome?

Children ◽

10.3390/children8090735 ◽

2021 ◽

Vol 8 (9) ◽

pp. 735

Author(s):

Jun-il Park ◽

Joo-Hyun Kee ◽

Ja Young Choi ◽

Shin-seung Yang

Keyword(s):

Clinical Symptoms ◽

Limited Range ◽

Neck Mass ◽

Congenital Muscular Torticollis ◽

Limited Range Of Motion ◽

Chi Squared ◽

Long Term Follow Up ◽

Muscular Torticollis

It has been reported that congenital muscular torticollis (CMT) may result in secondary scoliosis over long-term follow-ups. However, there are few reports on whether CMT causes pelvic malalignment syndrome (PMS). This study aimed to investigate the relationship between CMT and PMS and to determine the factors associated with the development of PMS in children with longstanding CMT. Medical records of 130 children with CMT who had long-term follow-up were reviewed retrospectively. The chi-squared test and logistic regression analysis were used to determine which initial clinical parameters contributed to the development of PMS. Among 130 children with CMT, 51 (39.2%) developed PMS with or without compensatory scoliosis during long-term follow-up, indicating a high prevalence of PMS in children with a CMT history. Initial clinical symptoms such as a limited range of motion of the neck or the presence of a neck mass could not predict the development of PMS. Even if the clinical symptoms are mild, long-term follow-up of children with CMT is essential to screen for PMS.

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Simulated Deep Flexion With Muscle Loading: Whole Leg Versus Knee Kinematics

ASME 2008 Summer Bioengineering Conference, Parts A and B ◽

10.1115/sbc2008-192560 ◽

2008 ◽

Author(s):

Amber N. Reeve ◽

Chadd W. Clary ◽

Amit M. Mane ◽

Lorin P. Maletsky

Keyword(s):

Knee Joint ◽

Activities Of Daily Living ◽

Knee Flexion ◽

Daily Living ◽

Knee Kinematics ◽

Limited Range ◽

Deep Flexion ◽

Limited Range Of Motion ◽

Muscle Loading

Many activities of daily living during work, exercise, religious worship, and hobbies require deep knee flexion. Activities such as rising from a low chair or getting into or out of a bath require between 100° and 160° of knee flexion [1]. Other activities such as kneeling or squatting to pick an item off the ground can be difficult with a limited range of motion. Beside deep knee flexion being important for daily living activities, it is essential in non-Western cultures that commonly sit in deep knee-bending positions. In vitro studies looking at knee function often focus solely on the knee joint, ignoring the effect of the muscle, ligament, and tendon constraints of the ankle, and simplifying or neglecting muscle loads. The effects of these assumptions on kinematics are unknown. The purpose of this study was to compare a squatting activity for: 1) whole leg versus knee specimens, and 2) different combinations of quadriceps and hamstrings loading.

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The Disability Discrimination Act 1995: implications for psychiatrists

Advances in Psychiatric Treatment ◽

10.1192/apt.9.6.397 ◽

2003 ◽

Vol 9 (6) ◽

pp. 397-404 ◽

Cited By ~ 6

Author(s):

Liz Sayce ◽

Jed Boardman

Keyword(s):

Mental Health ◽

Adverse Effect ◽

Educational Opportunities ◽

Service Users ◽

Disability Discrimination ◽

Term Adverse Effect ◽

Discrimination In Employment ◽

Disability Discrimination Act ◽

Employment Rights

The Disability Discrimination Act, passed by Parliament in 1995, is an important piece of legislation with the potential to protect the employment rights of people with disabilities. It covers people with physical or mental impairments that have a substantial and long-term adverse effect on their ability to carry out normal day-to-day activities. The Act has sections regarding protection from discrimination in employment, in the provision of goods, services and facilities, and in education. These parts of the Act have implications for people working in mental health services when they are considering employment and educational opportunities for service users.

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Proximal interphalangeal joint replacement with an unconstrained pyrocarbon prosthesis (Ascension®): a long-term follow-up

Journal of Hand Surgery (European Volume) ◽

10.1177/1753193412469898 ◽

2012 ◽

Vol 38 (6) ◽

pp. 680-685 ◽

Cited By ~ 20

Author(s):

G. Heers ◽

H. R. Springorum ◽

C. Baier ◽

J. Götz ◽

J. Grifka ◽

...

Keyword(s):

Range Of Motion ◽

Limited Range ◽

Degenerative Joint Disease ◽

Proximal Interphalangeal Joint ◽

Joint Disease ◽

Long Term Results ◽

Complication Rates ◽

Limited Range Of Motion

There have been limited publications that report long-term outcomes of pyrocarbon implants. This report describes both clinical and radiographic long-term results for patients who have been treated with pyrocarbon proximal interphalangeal implants. Thirteen implants in ten patients are reported for an average follow-up of 8.3 years (range 6.2–9.3). All patients were suffering from degenerative joint disease. Five of the 13 digits were free of pain, the remaining eight digits had mild to moderate pain (visual analogue scale 2–5). The average active range of motion was 58° (SD 19°) at latest examination. X-ray results were unremarkable in six digits with an acceptable position of the prosthesis. However, in seven patients significant radiolucent lines (≥ 1 mm) were observed. Three prostheses demonstrated a migration of the proximal component, and one a subsidence of the distal component. Our study does not support the use of this implant for treatment of osteoarthritis of the finger joint owing to high complication rates and limited range of motion.

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Efficacy and long-term adverse effect pattern of lovastatin

The American Journal of Cardiology ◽

10.1016/0002-9149(88)90004-5 ◽

1988 ◽

Vol 62 (15) ◽

pp. J28-J34 ◽

Cited By ~ 229

Author(s):

Jonathan A. Tobert

Keyword(s):

Adverse Effect ◽

Term Adverse Effect

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Selenium in the Prevention of Anthracycline-Induced Cardiac Toxicity in Children with Cancer

Journal of Oncology ◽

10.1155/2012/651630 ◽

2012 ◽

Vol 2012 ◽

pp. 1-6 ◽

Cited By ~ 2

Author(s):

Nurdan Tacyildiz ◽

Derya Ozyoruk ◽

Guzin Ozelci Kavas ◽

Gulsan Yavuz ◽

Emel Unal ◽

...

Keyword(s):

Adverse Effect ◽

Plasma Level ◽

Protective Effect ◽

Pediatric Cancer ◽

Cardiac Toxicity ◽

Chemotherapeutic Agents ◽

Children With Cancer ◽

Term Adverse Effect ◽

Pediatric Cancer Patients

High cumulative doses of anthracyclines (300–500 mg/m2) used in the treatment of children with cancer may result in cardiotoxicity, a major long-term adverse effect that limits clinical usefulness of this class of chemotherapeutic agents. We assessed anthracycline-induced cardiotoxicity by measuring Pro-BNP levels and echocardiographic (ECHO) findings and investigated potential protective effect of selenium (Se) supplementation in a group of pediatric cancer patients. Plasma level of Pro-BNP was measured, and ECHO was performed in 67 patients (45 boys, 22 girls; ages 2–18 years; median age 12 years) after they completed anthracycline-containing chemotherapy. Serum Se level was measured in 37 patients. Eleven patients had high Pro-BNP levels and/or cardiac failure with Pro-BNP levels of 10–8,022 pg/mL (median 226.3 pg/mL; laboratory normal level is less than 120 pg/mL). Serum Se levels were low (20–129 mcg/L, median 62 mcg/L) in ten of these eleven patients. Eight of 10 patients with low Se and high Pro-BNP levels were supplemented with Se 100 mcg/day for a period of 4–33 months (median 6 months) which resulted in improvement in Pro-BNP and/or ECHO findings. These results suggest that Se supplementation may have a role in protection against anthracycline-induced cardiac toxicity.

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