scholarly journals Selenium in the Prevention of Anthracycline-Induced Cardiac Toxicity in Children with Cancer

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Nurdan Tacyildiz ◽  
Derya Ozyoruk ◽  
Guzin Ozelci Kavas ◽  
Gulsan Yavuz ◽  
Emel Unal ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Plasma Level ◽  
Protective Effect ◽  
Pediatric Cancer ◽  
Cardiac Toxicity ◽  
Chemotherapeutic Agents ◽  
Children With Cancer ◽  
Term Adverse Effect ◽  
Pediatric Cancer Patients

High cumulative doses of anthracyclines (300–500 mg/m2) used in the treatment of children with cancer may result in cardiotoxicity, a major long-term adverse effect that limits clinical usefulness of this class of chemotherapeutic agents. We assessed anthracycline-induced cardiotoxicity by measuring Pro-BNP levels and echocardiographic (ECHO) findings and investigated potential protective effect of selenium (Se) supplementation in a group of pediatric cancer patients. Plasma level of Pro-BNP was measured, and ECHO was performed in 67 patients (45 boys, 22 girls; ages 2–18 years; median age 12 years) after they completed anthracycline-containing chemotherapy. Serum Se level was measured in 37 patients. Eleven patients had high Pro-BNP levels and/or cardiac failure with Pro-BNP levels of 10–8,022 pg/mL (median 226.3 pg/mL; laboratory normal level is less than 120 pg/mL). Serum Se levels were low (20–129 mcg/L, median 62 mcg/L) in ten of these eleven patients. Eight of 10 patients with low Se and high Pro-BNP levels were supplemented with Se 100 mcg/day for a period of 4–33 months (median 6 months) which resulted in improvement in Pro-BNP and/or ECHO findings. These results suggest that Se supplementation may have a role in protection against anthracycline-induced cardiac toxicity.

scholarly journals Lymphoedema in patients with lentigo maligna treated with imiquimod: a long-term adverse effect

2018 ◽  
Vol 178 (6) ◽  
pp. 1441-1442 ◽  
Author(s):  
D. Tio ◽  
G. Kirtschig ◽  
R. Hoekzema ◽  
C. van Montfrans
Keyword(s):  
Adverse Effect ◽  
Lentigo Maligna ◽  
Term Adverse Effect

The Disability Discrimination Act 1995: implications for psychiatrists

2003 ◽  
Vol 9 (6) ◽  
pp. 397-404 ◽  
Author(s):  
Liz Sayce ◽  
Jed Boardman
Keyword(s):  
Mental Health ◽  
Adverse Effect ◽  
Educational Opportunities ◽  
Service Users ◽  
Disability Discrimination ◽  
Term Adverse Effect ◽  
Discrimination In Employment ◽  
Disability Discrimination Act ◽  
Employment Rights

The Disability Discrimination Act, passed by Parliament in 1995, is an important piece of legislation with the potential to protect the employment rights of people with disabilities. It covers people with physical or mental impairments that have a substantial and long-term adverse effect on their ability to carry out normal day-to-day activities. The Act has sections regarding protection from discrimination in employment, in the provision of goods, services and facilities, and in education. These parts of the Act have implications for people working in mental health services when they are considering employment and educational opportunities for service users.

scholarly journals Psychological Distress and the Impact of Social Support on Fathers and Mothers of Pediatric Cancer Patients: Long-Term Prospective Results

2005 ◽  
Vol 31 (8) ◽  
pp. 785-792 ◽  
Author(s):  
Barbara J. Wijnberg-Williams ◽  
Willem A. Kamps ◽  
Ed C. Klip ◽  
Josette E. H. M. Hoekstra-Weebers
Keyword(s):  
Social Support ◽  
Psychological Distress ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Pediatric Cancer Patients ◽  
The Impact

scholarly journals Intestinal Colonization and Nosocomial Spread of Clostridium difficile in Pediatric Cancer Patients Under Long-term Hospitalization

2008 ◽  
Vol 82 (5) ◽  
pp. 419-426 ◽  
Author(s):  
Mayumi MURABATA ◽  
Haru KATO ◽  
Hisako YANO ◽  
Masamichi OGURA ◽  
Junko SHIBAYAMA ◽  
...  
Keyword(s):  
Clostridium Difficile ◽  
Cancer Patients ◽  
Pediatric Cancer ◽  
Intestinal Colonization ◽  
Pediatric Cancer Patients

scholarly journals St. Jude Cloud—a Pediatric Cancer Genomic Data Sharing Ecosystem

2020 ◽  
Author(s):  
Clay McLeod ◽  
Alexander M. Gout ◽  
Xin Zhou ◽  
Delaram Rahbarinia ◽  
Andrew Thrasher ◽  
...  
Keyword(s):  
Data Sharing ◽  
Pediatric Cancer ◽  
Genomic Data ◽  
Public Access ◽  
Term Survival ◽  
Cancer Subtypes ◽  
Pediatric Cancer Patients ◽  
Unique Experience ◽  
Long Term Survivors

ABSTRACTEffective data sharing is key to accelerating research that will improve the precision of diagnoses, efficacy of treatments and long-term survival of pediatric cancer and other childhood catastrophic diseases. We present St. Jude Cloud (https://www.stjude.cloud), a cloud-based data sharing ecosystem developed via collaboration between St. Jude Children’s Research Hospital, DNAnexus, and Microsoft, for accessing, analyzing and visualizing genomic data from >10,000 pediatric cancer patients, long-term survivors of pediatric cancer and >800 pediatric sickle cell patients. Harmonized genomic data totaling 1.25 petabyes on St. Jude Cloud include 12,104 whole genomes, 7,697 whole exomes and 2,202 transcriptomes, which are freely available to researchers worldwide. The resource is expanding rapidly with regular data uploads from St. Jude’s prospective clinical genomics programs, providing public access as soon as possible rather than holding data back until publication. Three interconnected apps within the St. Jude Cloud ecosystem—Genomics Platform, Pediatric Cancer Knowledgebase (PeCan) and Visualization Community—provide a unique experience for simultaneously performing advanced data analysis in the cloud and enhancing the pediatric cancer knowledgebase. We demonstrate the value of the St. Jude Cloud ecosystem through use cases that classify 48 pediatric cancer subtypes by gene expression profiling and map mutational signatures across 35 subtypes of pediatric cancer.

scholarly journals LINC-01. COMPLIANCE TO FOLLOW UP IN PEDIATRIC PATIENTS WHO HAVE RECEIVED CRANIOSPINAL IRRADIATION

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii378-iii378
Author(s):  
Khin Pyone ◽  
Thwe Tun ◽  
Yin Win ◽  
Aye Thinn ◽  
Khin Win ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Pediatric Cancer ◽  
Pediatric Patients ◽  
Tertiary Hospital ◽  
Craniospinal Irradiation ◽  
Long Term Effects ◽  
Pediatric Cancer Patients ◽  
Need To Evaluate

Abstract OBJECTIVE Attendance to follow-up after completion of cancer treatment is understudied area. Pediatric cancer patients have sequelae of illness or treatment. Many have no symptom immediately after completion of treatment. Long term follow-up is important to access disease control, early diagnosis of recurrence, second cancer and treatment-related morbidities. Purpose of this study was to evaluate the compliance to follow-up in pediatric patients treated with craniospinal irradiation (CSI). METHODS This was retrospective review of follow-up in pediatric neuro-oncology patients who received (CSI) from January 2017 to June 2018 in the Radiotherapy Department of Yangon General Hospital, Myanmar. RESULT: Twenty-three patients received CSI; majority (43%) were medulloblastoma. Median age was 7.5 years (3–17 years). Only seven patients (30.4%) were attended to follow-up more than 6 months after completion of treatment. More than two-thirds of patients (n=16,69.6%) were lost to follow-up. Patients in active follow-up were diagnosed and treated at earlier age below 10years (n=5,21.7%). Demographically, 5 patients (22%) were living in the region around tertiary hospital. Sixteen patients (69.6%) from rural area had limited transportation and difficulty for accommodation in which they were treated. In socioeconomic points, 18 parents (78.2%) had poor education and financial status, lack of understanding about disease, treatment, long-term effects and follow-up. CONCLUSION Although this was limited data in CSI patients only, loss to follow-up after 6 months was high. We need to evaluate in all pediatric cancer patients and collaborate to provide financial support, childcare centres for lodging, transportation and health education to promote compliance to follow-up.

Sign in / Sign up

Export Citation Format

Share Document