Does the FT3-to-FT4 ratio easily predict the progression of NAFLD and NASH cirrhosis?

Background Factors causing progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis (NASH) and liver cirrhosis remain relatively unknown. We aimed to evaluate the power and effectiveness of the free triiodothyronine (FT3)-to-free thyroxine (FT4) ratio to predict non-alcoholic fatty liver disease (NAFLD)/liver fibrosis and NASH cirrhosis severity. Methods Patients (n = 436) with NASH-associated liver cirrhosis (n = 68), patients with liver biopsy-proven NAFLD (n = 226), or healthy participants (n = 142) were enrolled between January 2010 and January 2020. The aspartate aminotransferase-to-thrombocyte ratio (APRI), NAFLD fibrosis score, albumin–bilirubin score (ALBI), aspartate aminotransferase (AST)-to-alanine aminotransferase (ALT) ratio, FT3-to-FT4 ratio, and Fibrosis-4 (FIB-4) were calculated and evaluated. Results All parameters were significantly higher in NASH cirrhosis than in the healthy group. Body mass index, ALT, fasting insulin, homeostatic model assessment for insulin resistance, and triglyceride levels were significantly higher in liver biopsy-proven NAFLD than in the healthy group. The APRI, NAFLD fibrosis score, ALBI, AST-to-ALT ratio, FT3-to-FT4 ratio, and FIB-4 were significantly higher in the NASH cirrhosis group than in the healthy group. In patients with biopsy-proven NAFLD, the FT3-to-FT4 ratio was significantly lower than in the healthy group. Conclusion The FT3-to-FT4 ratio is an effective and useful indicator to predict NAFLD/liver fibrosis and NASH cirrhosis severity.

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PA.88 TRANSIENT ELASTOGRAPHY IN PATIENTS WITH NON ALCOHOLIC FATTY LIVER DISEASE (NAFLD). CORRELATION WITH LIVER BIOPSY AND NAFLD FIBROSIS SCORE

Digestive and Liver Disease ◽

10.1016/s1590-8658(08)60283-2 ◽

2008 ◽

Vol 40 ◽

pp. S107

Author(s):

A. Grasso ◽

S. Bottone ◽

F. Malfatti ◽

H. Martines ◽

G. Menardo

Keyword(s):

Liver Disease ◽

Liver Biopsy ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Transient Elastography ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Nafld Fibrosis Score ◽

Alcoholic Fatty Liver Disease

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S1182 A New Frontier of Non-Alcoholic Fatty Liver Disease (NAFLD) Fibrosis Estimation: Comparing APRI and NAFLD Fibrosis Score (NFS) to Assess Liver Fibrosis Levels in Patients With and Without Diabetes

The American Journal of Gastroenterology ◽

10.14309/01.ajg.0000706776.35223.f9 ◽

2020 ◽

Vol 115 (1) ◽

pp. S591-S592

Author(s):

Scott Berger ◽

Natalie Nguyen ◽

Allison N. Boden ◽

Javier Sanchez ◽

Ana L. Romero ◽

...

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Nafld Fibrosis Score ◽

New Frontier ◽

Alcoholic Fatty Liver Disease

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The THE ENHANCED LIVER CIRRHOSIS TEST (ELF) ACCURATELY IDENTIFIES CIRRHOSIS IN PATIENTS WITH CHRONIC LIVER DISEASE

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i6.288 ◽

2019 ◽

Vol 3 (6) ◽

Author(s):

Abdulrahman Hefdhallah Amer ◽

Dr. Hitesh N Shah

Keyword(s):

Liver Cirrhosis ◽

Liver Disease ◽

Liver Fibrosis ◽

Liver Biopsy ◽

Fatty Liver Disease ◽

Liver Diseases ◽

Transient Elastography ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Chronic liver disease (CLD) is the leading cause of death worldwide. That caused by Viral Hepatitis B and C (HBV, HCV), Alcoholic Liver Disease (ALD) and Non-Alcoholic Fatty Liver Disease (NAFLD). The present article provides an overview of the literature reporting some relevant biomarkers (ELF test) that have been found to be associated with liver fibrosis and that potentially may be used to predict the onset and/or monitor the progression of liver cirrhosis alternative the liver biopsy. This article provides an overview of the current published evidence on the clinical utility of the ELF test. This review collects the main evidence on the emerging role of Enhanced Liver Fibrosis (ELF) score as a prognostic marker of hepatitis, cirrhosis, and other liver diseases as the marker in cases of intoxication with organ phosphorus compounds and myocardial infarction or acute infections, and evidence that proves to use the Enhanced Liver Fibrosis as clinical practice presents an attractive alternative to both biopsy and imaging modalities that require significant high costs, also trained clinician.The most recent study proves that enhanced liver fibrosis score can be used instead of liver biopsy test and Transient Elastography for diagnosing liver fibrosis. Keywords: Enhanced Liver Fibrosis Score, Transient Elastography, Liver, Liver Biopsy, Liver Diseases Alcoholic Liver Disease (ALD) and Non-Alcoholic Fatty Liver Disease (NAFLD).

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Relationship of serum vaspin, nafld fibrosis score to ultrasonographic detection and quantification of steatosis in nonalcoholic fatty liver disease patients

QJM ◽

10.1093/qjmed/hcab100.122 ◽

2021 ◽

Vol 114 (Supplement_1) ◽

Author(s):

Essam Mohamed Byoumy ◽

Moataz Mohamed Sayed ◽

Shereen Abo Baker Abd El-Rahman ◽

Sara Abd Elkader Al-Nakib ◽

Mohamed Magdy Salama ◽

...

Keyword(s):

Liver Disease ◽

Fatty Liver ◽

Fatty Liver Disease ◽

Liver Steatosis ◽

Control Group ◽

P Value ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Nafld Fibrosis Score ◽

Detection And Quantification

Abstract Background Ectopic hepatic lipid accumulation is closely related to the development of insulin resistance, which is regarded as one of the most significant risk factors of non-alcoholic fatty liver disease (NAFLD). The aim of the study was to evaluate and validate the diagnostic value of serum vaspin, NAFLD Fibrosis Score and sonograghic parameters in detection and quantification of liver steatosis and determining further need for liver biopsy or other means to establish NAFLD diagnosis. Methods This study was carried out on 60 patients having bright liver in ultrasonography and 30 healthy persons as controls. The subjects were divided into the following groups; group A: 30 age and sex matched healthy volunteers (control group), group B: 20 patients with fatty liver grade I, group C: 20 patients with fatty liver grade II and group D: 20 patients with fatty liver grade III. Results serum vaspine levels and NAFLD fibrosis score, were significantly higher in patients than in controls with p-value:<0.001. There was a significant positive correlation between NAFLD fibrosis score and serum vaspin and ultrasonographic findngs of NAFLD with p-value: <0.001. Conclusion Vaspin seem to be the most suitable non-invasive biomarker in predicting both intrahepatic lipid contents in NAFLD group.

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Correlation Between Point Shear Wave Elastography and Liver Function Tests as A Predictor of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

10.53350/pjmhs211571936 ◽

2021 ◽

Vol 15 (7) ◽

pp. 1936-1939

Author(s):

Shahla Mohammed Saeed Rasul ◽

Ali Khalaf Salim ◽

Hiwa Abubakr Hussein

Keyword(s):

Liver Disease ◽

Liver Fibrosis ◽

Liver Function ◽

Fatty Liver ◽

Shear Wave ◽

Fatty Liver Disease ◽

Liver Function Tests ◽

Fibrosis Score ◽

Alcoholic Fatty Liver ◽

Alcoholic Fatty Liver Disease

Background: Nowadays, generating shear waves and simulation of the liver tissue is done using point shear-wave elastographic (pSWE) techniques which uess acoustic radiation force impulse (ARFI). Objective: This study aimed to evaluate the correlation between pSWE and liver function tests (LFTs) to predict liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Materials and methods: It was a cross sectional study conducted in an Ultrasound Clinic in Suleymaniya city. The duration of the study was from 1st of November, 2018 to 30th of June, 2019 which conducted on 50 NAFLD patients. After confirming NAFLD diagnosis, the patients were referred to Ultrasound Clinic to go under pSWE test. Results: The data showed that the mean PSWE of NAFLD patient was 4.12±0.87 Kpa; and 18% of them had high PSWE (> 4.6). Elastography fibrosis score was distributed to F0 (82%), F1 (6%), F2 (8%) and F3 (4%). There was a significant association between high APRI and high Aspartate Aminotransferase/Alanine Aminotransferase(AST/ALT) ratio (p=0.04). There was also a highly significant association between elastography fibrosis score and APRI fibrosis score among NAFLD patients (p<0.001). Conclusion: This study showed that the pSWE is a valuable noninvasive diagnostic technique for predicting liver fibrosis among NAFLD patients and there is significant correlation between APRI and pSWE scores. Keywords: Non-alcoholic fatty liver disease, Point shears wave elastography, Liver fibrosis.

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