A Double-Blind Comparative Study with Dolo-Neurobion® and its Separate Constituents in the Treatment of Polyneuritis

1974 ◽  
Vol 2 (1) ◽  
pp. 32-35 ◽  
Author(s):  
E Reyes-Armijo

A double-blind study was carried out with Dolo-Neurobion® and matching tablets containing: the vitamin B combination, and the metamizol component of the preparation. Forty-five patients suffering from polyneuritis were each treated with eight tablets a day for fourteen days. All fifteen patients who received Dolo-Neurobion were free from pain after treatment but this result was not observed in the patients treated with the vitamin combination alone nor with the metamizol component of the preparation. Dolo-Neurobion also proved more successful after the first half of the treatment (one week), the degree of pain being reduced more significantly than with the other two forms of medication.

1989 ◽  
Vol 17 (1) ◽  
pp. 24-27 ◽  
Author(s):  
L. Ghys ◽  
J.-P. Rihoux

In a double-blind study performed in 81 healthy volunteers, 10 mg cetirizine and 60 mg terfenadine given orally in a single administration significantly inhibited skin reactivity to histamine. Astemizole (10 mg) was completely ineffective. The inhibitory effect of cetirizine was potent and regular whereas 6/28 (21%) volunteers did not respond to terfenadine. The difference observed beween cetirizine and terfenadine might be due to differences in the metabolism of the two drugs after administration: terfenadine is rapidly and extensively metabolized whereas cetirizine is directly active without the need for biotransformation and, indeed is poorly metabolized.


2006 ◽  
Vol 63 (5) ◽  
pp. AB190 ◽  
Author(s):  
Cheol Hee Park ◽  
Jong Hyeok Kim ◽  
Jae One Jung ◽  
Joon Ho Moon ◽  
Woon Geon Shin ◽  
...  

2016 ◽  
Vol 10 (3) ◽  
pp. 602 ◽  
Author(s):  
Yashpal Singh ◽  
BhagyaRanjan Jena ◽  
Anil Paswan ◽  
Sandeep Loha ◽  
AnilPrasad Singh ◽  
...  

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