scholarly journals Comparative Study of Magnesium Sulphate added to Bupivacaine and Ropivacaine Local Infiltration of Wound for Postoperative Analgesia in Patients Undergoing Upper Abdominal Surgery: A Randomized Double Blind Study

Pain ◽  
1994 ◽  
Vol 59 (1) ◽  
pp. 135-140 ◽  
Author(s):  
Pilar Taurà ◽  
Vicente Planella ◽  
Jaume Balust ◽  
Joan Beltran ◽  
Teresa Anglada ◽  
...  

Thorax ◽  
1993 ◽  
Vol 48 (7) ◽  
pp. 693-697 ◽  
Author(s):  
N M Siafakas ◽  
A Stoubou ◽  
M Stathopoulou ◽  
V Haviaras ◽  
N Tzanakis ◽  
...  

1989 ◽  
Vol 17 (1) ◽  
pp. 24-27 ◽  
Author(s):  
L. Ghys ◽  
J.-P. Rihoux

In a double-blind study performed in 81 healthy volunteers, 10 mg cetirizine and 60 mg terfenadine given orally in a single administration significantly inhibited skin reactivity to histamine. Astemizole (10 mg) was completely ineffective. The inhibitory effect of cetirizine was potent and regular whereas 6/28 (21%) volunteers did not respond to terfenadine. The difference observed beween cetirizine and terfenadine might be due to differences in the metabolism of the two drugs after administration: terfenadine is rapidly and extensively metabolized whereas cetirizine is directly active without the need for biotransformation and, indeed is poorly metabolized.


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