Treatment of Patients Aged over 50 Years with Non-Osseous Ewing's Sarcoma Family Tumors: Five Cases and Review of Literature

2008 ◽  
Vol 94 (6) ◽  
pp. 809-812 ◽  
Author(s):  
Gil Bar-Sela ◽  
Avivit Peer ◽  
Shelly Rothschild ◽  
Nissim Haim
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Pediatric Population ◽  
Infectious Complications ◽  
Treatment Modalities ◽  
Review Of Literature ◽  
Poor Prognostic Factor ◽  
Treatment Delays ◽  
Chemotherapy Protocol ◽  
Dose Reductions

Background Most clinical trials on Ewing's sarcoma family of tumors include pediatric and adolescent populations, whereas clinical data on older patients are limited. Patients and Methods We report on 5 patients older than 50 years with a tumor of the Ewing's sarcoma family treated recently in our department. Results Myelosuppression and infectious complications were the main toxicity encountered. Major dose reductions and/or treatment delays were required in all 5 patients. One patient died of septic shock. Complete remission was achieved in the remaining 4 patients with the addition of different treatment modalities. One patient had lung metastasis 3 years after starting chemotherapy, and 3 patients have remained without evidence of recurrent disease for 1–6 years from the onset of chemotherapy. Conclusions There is no definite answer as to whether older age is a poor prognostic factor in patients with a tumor of the Ewing's sarcoma family. In our experience, patients over 50 poorly tolerated the standard chemotherapy protocol used in the pediatric population.

Non Conventional Fractionation in Radiotherapy of the Musculo-Skeletal Sarcomas

1998 ◽  
Vol 84 (2) ◽  
pp. 167-170 ◽  
Author(s):  
Enza Barbieri ◽  
Giovanni Frezza ◽  
Ombretta Martelli ◽  
Stefano Neri ◽  
Mario Mercuri ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Late Effects ◽  
Surgical Complications ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Young Patients ◽  
Soft Tissue Sarcomas ◽  
Treatment Modalities ◽  
Complication Rates ◽  
Bulky Disease

In 1989 we started an accelerated hyperfractionated schedule of radiotherapy (two 1.6 Gy daily fractions) in standard risk localized Ewing's sarcoma of bone, with the aim at reducing late effects in young patients and at improving disease control through a better integration of treatment modalities. From 1991, the same schedule was used in preoperative radiotherapy of adult soft tissue sarcomas of the extremities: the main purpose was to reduce the time to surgery and to evaluate surgical complications in comparison with a previous experience of hypofractionated radiotherapy (one 3 Gy daily fraction). From 1991 to 1997, 76 patients with Ewing's sarcoma and 24 patients with soft tissue sarcoma were treated at our Institution. Results and complication rates are analyzed in comparison with historical data. In Ewing's sarcoma, a correct evaluation of improvement in local control was difficult because of changing treatment policy (bulky disease was not included in the present series). Late effects, as evaluated in patients with a minimum follow-up of 3 years, occurred with similar incidence, but at higher total dose levels in patients treated with accelerated hyperfractionation. In patients with soft tissue sarcomas, incidence of surgical complications is reduced as compared to historical experience. Major problems of wound healing were seen in association with intraoperative brachitherapy boost.

scholarly journals Ewing's Sarcoma of the Cervical Spine

2017 ◽  
Vol 07 (02) ◽  
pp. 086-089
Author(s):  
Meenakshi Bhattacharjee ◽  
Winston Huh ◽  
Vandana Thapar ◽  
Paul Dahm
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Pediatric Population ◽  
Signs And Symptoms ◽  
Neck Mass ◽  
Neurological Deficits ◽  
Resonance Imaging ◽  
Neck Trauma ◽  
Motor Weakness ◽  
Posterior Neck

AbstractIn this article, we present the case of a 6-year-old female presented to the emergency department with progressive ascending motor weakness leading to cardiac arrest. The recent medical history included neck trauma 1 month prior to admission, 2 weeks of subjective fevers, and 1 day of urinary incontinence. After stabilization, and a review of the recent signs and symptoms, a magnetic resonance imaging of the neck revealed a posterior neck mass from C2 to T2. Neurosurgical removal of the mass was consistent with Ewing's sarcoma. Neck pain is a common presentation in the pediatric population, with the most common cause being traumatic. When coupled with neurological deficits, further studies are warranted to evaluate for organic causes.

Ewing's sarcoma of os calcis: Case report with a review of literature

1999 ◽  
Vol 38 (1) ◽  
pp. 61-65 ◽  
Author(s):  
Vikas Gupta ◽  
Ravi Mittal ◽  
S. Rastogi ◽  
J. Khurana
Keyword(s):  
Case Report ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Review Of Literature ◽  
Os Calcis

scholarly journals Tumor Vessel Development and Expansion in Ewing's Sarcoma: A Review of the Vasculogenesis Process and Clinical Trials with Vascular-Targeting Agents

Sarcoma ◽  
2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Keri S. Stewart ◽  
Eugenie S. Kleinerman
Keyword(s):  
Bone Marrow ◽  
Clinical Trials ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Pediatric Population ◽  
Vascular Supply ◽  
Molecular Regulation ◽  
Vascular Targeting ◽  
Tumor Vessel ◽  
Vessel Development

Ewing's sarcoma accounts for a disproportionately high portion of the overall pediatric mortality rate compared to its rare incidence in the pediatric population. Little progress has been made since the introduction of traditional chemotherapies, and understanding the biology of the tumor is critical for developing new therapies. Ewing's sarcomas rely on a functional vascular supply, which is formed by a combination of angiogenesis and vasculogenesis. Recent insights into the molecular regulation of bone marrow (BM) cell participation in vascular development have identified VEGF, SDF-1α, and DLL4 as critical players in the vasculogenesis process. Clinical trials using vascular targeting agents, specifically targeting VEGF or DLL4, are underway.

Calvarial Ewing's sarcoma, a rare childhood tumor: Report and a review of literature

2017 ◽  
Vol 65 (4) ◽  
pp. 904
Author(s):  
Prakash Nair ◽  
Varun Aggarwal ◽  
Krishna Kumar ◽  
Anitha Mathews ◽  
Mathew Abraham ◽  
...  
Keyword(s):  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Review Of Literature

scholarly journals RARE-30. A RARE CASE OF PRIMARY EWING’S SARCOMA OF THE CERVICAL SPINE

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii448-iii448
Author(s):  
Amandeep Kalra ◽  
Jayson Neil ◽  
Sarah Mann ◽  
Pierre Giglio
Keyword(s):  
Cervical Spine ◽  
Neck Pain ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Residual Disease ◽  
Comprehensive Evaluation ◽  
Pediatric Population ◽  
Local Treatment ◽  
Treatment Protocol ◽  
Almost All

Abstract Ewing sarcoma family of tumors predominantly affect the pediatric population in the long bones of the extremities or the pelvis, and only 8% of cases arise within the spine. Primary Ewing’s sarcoma of the cervical spine is extremely rare and less than 30 cases have been reported in the literature thus far. Here we present a case of primary Ewing’s sarcoma of the cervical spine in a 28-year-old female who presented with a three-month history of neck pain and right arm radiculopathy. MRI revealed a homogeneously contrast enhancing, eccentric mass with dural tail at C2-C7. After undergoing a hemilaminectomy, histopathology confirmed extraosseous Ewing’s sarcoma with CD99 positivity. A comprehensive systemic and neuraxis work-up ruled out overt metastasis. We extrapolated data from children’s cooperative group studies and IESS-II clinical trial to formulate a three phase treatment protocol as described below. To date, patient is in remission with no evidence of any residual disease in the cervical spine. In conclusion, although Primary Ewing’s sarcoma of the cervical spine is extremely rare it should be considered a differential diagnosis in patients with neck pain and a spinal mass under the age of thirty. Less than 25% of EFT’s present with overt metastasis and almost all have subclinical metastatic disease at the time of diagnosis, therefore, a comprehensive evaluation and systemic chemotherapy is recommended. We recommend a multidisciplinary approach of surgical decompression to preserve neurological functions, followed by compressed chemotherapy regimens, reevaluation for local treatment, and adjuvant chemotherapy.

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