Prevention of Meningeal CNS Involvement as a Factor Influencing the Duration of Complete Remission and Survival in Childhood Acute Lymphoblastic Leukemia

1977 ◽  
Vol 63 (4) ◽  
pp. 367-372
Author(s):  
Enrico Madon ◽  
Luca Cordero di Montezemolo ◽  
Guido Pastore
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Complete Remission ◽  
Prophylactic Treatment ◽  
Lymphoblastic Leukemia ◽  
Present Series ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cns Involvement

The influence on the duration of CR and survival of 2 modalities (MTX + hydrocortisone IT, with and without TCT) for the prevention of meningeal CNS involvement was assessed in 24 children with acute lymphoblastic leukemia. Of the 9 subjects who received MTX and hydrocortisone only, 42 % were still in CR 33 months after its attainment, as opposed to 75 % of the 15 who also received TCT. Survival at 33 months after diagnosis was 89 % and 82 % in the 2 groups. The results are compared with those obtained in an earlier series of 14 children who received no prophylactic treatment. Here CR at 45 months was 25 % and survival 46 %. Eight subjects died, as opposed to 3 (1 in CR) in the present series.

Nijmegen breakage syndrome (NBS) as a risk factor for CNS involvement in childhood acute lymphoblastic leukemia

2011 ◽  
Vol 57 (1) ◽  
pp. 160-162 ◽  
Author(s):  
Agata Pastorczak ◽  
Malgorzata Stolarska ◽  
Joanna Trelińska ◽  
Joanna Zawitkowska ◽  
Jerzy Kowalczyk ◽  
...  
Keyword(s):  
Risk Factor ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Nijmegen Breakage Syndrome ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cns Involvement

Ocular relapse in the anterior chamber in childhood acute lymphoblastic leukemia.

1987 ◽  
Vol 5 (2) ◽  
pp. 299-303 ◽  
Author(s):  
N Bunin ◽  
G Rivera ◽  
F Goode ◽  
H O Hustu
Keyword(s):  
Radiation Therapy ◽  
Acute Lymphoblastic Leukemia ◽  
Complete Remission ◽  
Anterior Chamber ◽  
Systemic Chemotherapy ◽  
Lymphoblastic Leukemia ◽  
Initial Diagnosis ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Topical Steroids

We reviewed 11 cases of ocular relapse in the anterior chamber in children with acute lymphoblastic leukemia (ALL), representing 0.5% of all primary relapses seen at this center. Nine patients had hypopyon, and two had iris involvement only. Concomitant testicular relapse was present in two children and hematologic relapse in one. Ocular relapse occurred at 12 to 74 months (median, 36 months) from the data of initial diagnosis. Children who relapsed after therapy was discontinued did so within 1 year of completing therapy. Topical steroids and systemic chemotherapy were administered to all patients with ocular relapse; four also received radiation to the involved eye (600 to 1,050 cGy). Four children, each with a prolonged initial complete remission, remain free of disease for 15+, 32+, 34+, and 145+ months following anterior chamber relapse; three had received radiation therapy. Five patients died of recurrent leukemia, and two of infection while in remission. Aggressive retreatment appears warranted in cases of anterior chamber relapse of ALL, as some of these children may attain prolonged new remissions.

scholarly journals Cytogenetic Instability in Childhood Acute Lymphoblastic Leukemia Survivors

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
María Sol Brassesco ◽  
Danilo Jordão Xavier ◽  
Marjori Leiva Camparoto ◽  
Ana Paula Montaldi ◽  
Paulo Roberto D'Auria Vieira de Godoy ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Complete Remission ◽  
Late Effects ◽  
Lymphoblastic Leukemia ◽  
Chromosome Rearrangements ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Peripheral Lymphocytes ◽  
Life Threatening ◽  
Therapy Completion ◽  
Cure Rates

Contemporary anticancer therapies have largely improved the outcome for children with cancer, especially for Acute Lymphoblastic Leukemia (ALL). Actually, between 78% and 85% of patients achieve complete remission and are alive after 5 years of therapy completion. However, as cure rates increase, new concerns about the late effects of genotoxic treatment emerge, being the risk of developing secondary neoplasias, the most serious life-threatening rising problem. In the present paper, we describe and review the cytogenetic findings in peripheral lymphocytes from ALL survivors, and discuss aspects associated to the occurrence of increased chromosome rearrangements in this growing cohort.

High Interleukin-15 Expression Characterizes Childhood Acute Lymphoblastic Leukemia With Involvement of the CNS

2007 ◽  
Vol 25 (30) ◽  
pp. 4813-4820 ◽  
Author(s):  
Gunnar Cario ◽  
Shai Izraeli ◽  
Anja Teichert ◽  
Peter Rhein ◽  
Julia Skokowa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Lymphoblastic Leukemia ◽  
Expression Profiles ◽  
Lymphoblastic Leukemia ◽  
Gene Expression Profiles ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Leukemic Cells ◽  
Cns Involvement ◽  
Childhood All ◽  
Interleukin 15

Purpose Applying current diagnostic methods, overt CNS involvement is a rare event in childhood acute lymphoblastic leukemia (ALL). In contrast, CNS-directed therapy is essential for all patients with ALL because without it, the majority of patients eventually will experience relapse. To approach this discrepancy and to explore potential distinct biologic properties of leukemic cells that migrate into the CNS, we compared gene expression profiles of childhood ALL patients with initial CNS involvement with the profiles of CNS-negative patients. Patients and Methods We evaluated leukemic gene expression profiles from the bone marrow of 17 CNS-positive patients and 26 CNS-negative patients who were frequency matched for risk factors associated with CNS involvement. Results were confirmed by real-time quantitative polymerase chain reaction analysis and validated using independent patient samples. Results Interleukin-15 (IL-15) expression was consistently upregulated in leukemic cells of CNS-positive patients compared with CNS-negative patients. In multivariate analysis, IL-15 expression levels greater than the median were associated with CNS involvement compared with expression equal to or less than the median (odds ratio [OR] = 10.70; 95% CI, 2.95 to 38.81). Diagnostic likelihood ratios for CNS positivity were 0.09 (95% CI, 0.01 to 0.65) for the first and 6.93 (95% CI, 2.55 to 18.83) for the fourth IL-15 expression quartiles. In patients who were CNS negative at diagnosis, IL-15 levels greater than the median were associated with subsequent CNS relapse compared with expression equal to or less than the median (OR = 13.80; 95% CI, 3.38 to 56.31). Conclusion Quantification of leukemic IL-15 expression at diagnosis predicts CNS status and could be a new tool to further tailor CNS-directed therapy in childhood ALL.

Genetic characterization of high hyperdiploidy in childhood acute lymphoblastic leukemia

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
R Vagkopoulou ◽  
C Eckert ◽  
U Ungethüm ◽  
G Körner ◽  
M Stanulla ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Genetic Characterization ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia
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