Nijmegen breakage syndrome (NBS) as a risk factor for CNS involvement in childhood acute lymphoblastic leukemia

2011 ◽  
Vol 57 (1) ◽  
pp. 160-162 ◽  
Author(s):  
Agata Pastorczak ◽  
Malgorzata Stolarska ◽  
Joanna Trelińska ◽  
Joanna Zawitkowska ◽  
Jerzy Kowalczyk ◽  
...  
Keyword(s):  
Risk Factor ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Nijmegen Breakage Syndrome ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cns Involvement

The C282Y Mutation of HFE Is Another Male-Specific Risk Factor for Childhood Acute Lymphoblastic Leukemia

Blood ◽  
1999 ◽  
Vol 94 (11) ◽  
pp. 3957-3958 ◽  
Author(s):  
M. Tevfik Dorak ◽  
Alan K. Burnett ◽  
Mark Worwood ◽  
Anne M. Sproul ◽  
Brenda E.S. Gibson
Keyword(s):  
Risk Factor ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
C282y Mutation ◽  
Specific Risk Factor ◽  
Specific Risk ◽  
Male Specific

Prevention of Meningeal CNS Involvement as a Factor Influencing the Duration of Complete Remission and Survival in Childhood Acute Lymphoblastic Leukemia

1977 ◽  
Vol 63 (4) ◽  
pp. 367-372
Author(s):  
Enrico Madon ◽  
Luca Cordero di Montezemolo ◽  
Guido Pastore
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Complete Remission ◽  
Prophylactic Treatment ◽  
Lymphoblastic Leukemia ◽  
Present Series ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Cns Involvement

The influence on the duration of CR and survival of 2 modalities (MTX + hydrocortisone IT, with and without TCT) for the prevention of meningeal CNS involvement was assessed in 24 children with acute lymphoblastic leukemia. Of the 9 subjects who received MTX and hydrocortisone only, 42 % were still in CR 33 months after its attainment, as opposed to 75 % of the 15 who also received TCT. Survival at 33 months after diagnosis was 89 % and 82 % in the 2 groups. The results are compared with those obtained in an earlier series of 14 children who received no prophylactic treatment. Here CR at 45 months was 25 % and survival 46 %. Eight subjects died, as opposed to 3 (1 in CR) in the present series.

Birth Weight as a Risk Factor for Childhood Acute Lymphoblastic Leukemia

1987 ◽  
Vol 4 (1) ◽  
pp. 63-72 ◽  
Author(s):  
Leslie L. Robison ◽  
Mary Codd ◽  
Paul Gunderson ◽  
Joseph P. Neglia ◽  
W. Anthony Smithson ◽  
...  
Keyword(s):  
Risk Factor ◽  
Birth Weight ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia

Low Incidence of Osteonecrosis in Childhood Acute Lymphoblastic Leukemia Treated With ALL-97 and ALL-02 Study of Japan Association of Childhood Leukemia Study Group

2018 ◽  
Vol 36 (9) ◽  
pp. 900-907 ◽  
Author(s):  
Kenichi Sakamoto ◽  
Toshihiko Imamura ◽  
Kentaro Kihira ◽  
Koji Suzuki ◽  
Hisashi Ishida ◽  
...  
Keyword(s):  
Risk Factor ◽  
Acute Lymphoblastic Leukemia ◽  
Childhood Leukemia ◽  
Lymphoblastic Leukemia ◽  
Significant Risk ◽  
Low Frequency ◽  
Concomitant Administration ◽  
Significant Risk Factor ◽  
Japanese Patients ◽  
Childhood Acute Lymphoblastic Leukemia

Purpose Osteonecrosis (ON) is a serious complication of the treatment of childhood acute lymphoblastic leukemia (ALL); however, data relating to ON in Asian pediatric patients with ALL are scarce. Therefore, we performed a retrospective analysis of cohorts of Japanese patients with ALL to clarify the incidence, clinical characteristics, and risk factors of ON. Patients and Methods The incidence and characteristics of ON were determined in patients with ALL (n = 1,662) enrolled in two studies from the Japan Association of Childhood Leukemia Study (JACLS) group (n = 635 and n = 1,027 patients treated with the ALL-97 and ALL-02 protocols, respectively). Results In total, 24 of 1,662 patients suffered from ON, of which 12 of 635 and 12 of 1,027 patients were treated with the ALL-97 and the ALL-02 protocol, respectively. Of the 24 patients, 23 were older than 10 years. In multivariate analysis, age (≥ 10 years) was the sole significant risk factor for ON ( P < .001). Separate evaluation of patients ≥ 10 years of age indicated a 5-year cumulative incidence of ON of 7.2% (95% CI, 4.0% to 12.6%) and 5.9% (95% CI, 3.3% to 10.4%) in the ALL-97 and the ALL-02 protocol, respectively, which was lower than reported previously, despite an administration of dexamethasone (DEX) similar to that in comparable studies; however, concomitant administration of DEX and l-asparaginase was reduced in the JACLS protocols. Conclusion We identified a low frequency of ON in the JACLS ALL-97 and ALL-02 studies. Although the sole risk factor for ON was age (≥ 10 years), even among high-risk patients, ON incidence was significantly lower than that reported in previous studies. These results suggest that, not only the total amount of DEX, but also how DEX and l-asparaginase are administered, which affects the clearance of DEX, may be associated with ON incidence in patients with ALL.

The C282Y Mutation of HFE Is Another Male-Specific Risk Factor for Childhood Acute Lymphoblastic Leukemia

Blood ◽  
1999 ◽  
Vol 94 (11) ◽  
pp. 3957-3958
Author(s):  
M. Tevfik Dorak ◽  
Alan K. Burnett ◽  
Mark Worwood ◽  
Anne M. Sproul ◽  
Brenda E.S. Gibson
Keyword(s):  
Risk Factor ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
C282y Mutation ◽  
Specific Risk Factor ◽  
Specific Risk ◽  
Male Specific

High Interleukin-15 Expression Characterizes Childhood Acute Lymphoblastic Leukemia With Involvement of the CNS

2007 ◽  
Vol 25 (30) ◽  
pp. 4813-4820 ◽  
Author(s):  
Gunnar Cario ◽  
Shai Izraeli ◽  
Anja Teichert ◽  
Peter Rhein ◽  
Julia Skokowa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Lymphoblastic Leukemia ◽  
Expression Profiles ◽  
Lymphoblastic Leukemia ◽  
Gene Expression Profiles ◽  
Childhood Acute Lymphoblastic Leukemia ◽  
Leukemic Cells ◽  
Cns Involvement ◽  
Childhood All ◽  
Interleukin 15

Purpose Applying current diagnostic methods, overt CNS involvement is a rare event in childhood acute lymphoblastic leukemia (ALL). In contrast, CNS-directed therapy is essential for all patients with ALL because without it, the majority of patients eventually will experience relapse. To approach this discrepancy and to explore potential distinct biologic properties of leukemic cells that migrate into the CNS, we compared gene expression profiles of childhood ALL patients with initial CNS involvement with the profiles of CNS-negative patients. Patients and Methods We evaluated leukemic gene expression profiles from the bone marrow of 17 CNS-positive patients and 26 CNS-negative patients who were frequency matched for risk factors associated with CNS involvement. Results were confirmed by real-time quantitative polymerase chain reaction analysis and validated using independent patient samples. Results Interleukin-15 (IL-15) expression was consistently upregulated in leukemic cells of CNS-positive patients compared with CNS-negative patients. In multivariate analysis, IL-15 expression levels greater than the median were associated with CNS involvement compared with expression equal to or less than the median (odds ratio [OR] = 10.70; 95% CI, 2.95 to 38.81). Diagnostic likelihood ratios for CNS positivity were 0.09 (95% CI, 0.01 to 0.65) for the first and 6.93 (95% CI, 2.55 to 18.83) for the fourth IL-15 expression quartiles. In patients who were CNS negative at diagnosis, IL-15 levels greater than the median were associated with subsequent CNS relapse compared with expression equal to or less than the median (OR = 13.80; 95% CI, 3.38 to 56.31). Conclusion Quantification of leukemic IL-15 expression at diagnosis predicts CNS status and could be a new tool to further tailor CNS-directed therapy in childhood ALL.

Genetic characterization of high hyperdiploidy in childhood acute lymphoblastic leukemia

2009 ◽  
Vol 221 (03) ◽  
Author(s):  
R Vagkopoulou ◽  
C Eckert ◽  
U Ungethüm ◽  
G Körner ◽  
M Stanulla ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Genetic Characterization ◽  
Lymphoblastic Leukemia ◽  
Childhood Acute Lymphoblastic Leukemia
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