Modifications in the Concentrations of Circulating Myoglobin after Treatment with Low Doses of Adriamycin

1985 ◽  
Vol 71 (5) ◽  
pp. 463-468 ◽  
Author(s):  
Giovanni Carulli ◽  
Aldo Clerico ◽  
Alessandra Marini ◽  
Maria Grazia Del Chicca ◽  
Renato Vanacore ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Cancer Patients ◽  
Muscle Damage ◽  
Low Doses ◽  
Skeletal Muscle Damage ◽  
Creatine Kinase Mb

The modifications in the concentration of circulating myoglobin have been studied by means of a radioimmunoassay in 15 cancer patients undergoing polychemotherapy including adriamycin. In 8 patients significant increases in myoglobin levels were found after injection of low doses of the drug (25-50 mg/m2). Moreover, a disturbance of the normal biorhythm of the protein was evident in 12 patients. Creatine kinase-MB was evaluated by means of a radioimmunoassay, but there was no relation between an increase in the isoenzyme and an increase in myoglobin. No ECG modifications were detected. These data indicate that the measurement of myoglobin may offer an indication of myocardial or skeletal muscle damage caused by adriamycin.

Clinical and Analytical Validation of an Enzymometric Assay for Creatine Kinase-Mb isoenzyme

1986 ◽  
Vol 23 (4) ◽  
pp. 463-469 ◽  
Author(s):  
J E B Youens ◽  
J Calvin ◽  
C P Price
Keyword(s):  
Myocardial Infarction ◽  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Catalytic Activity ◽  
Muscle Damage ◽  
Analytical Validation ◽  
Skeletal Muscle Damage ◽  
Specific Measurement ◽  
Creatine Kinase Mb

The analytical validation of an immunoenzymometric technique for the specific measurement of the creatine kinase-MB isoenzyme is described. Its application is shown in the diagnosis of myocardial infarction. A difference in the correlation of the mass and catalytic activity of the CK-MB isoenzyme is shown between patients suffering myocardial infarction and those with skeletal muscle damage.

scholarly journals Comparison of Pro-Regenerative Effects of Carbohydrates and Protein Administrated by Shake and Non-Macro-Nutrient Matched Food Items on the Skeletal Muscle after Acute Endurance Exercise

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 744 ◽  
Author(s):  
Eduard Isenmann ◽  
Franziska Blume ◽  
Daniel Bizjak ◽  
Vera Hundsdörfer ◽  
Sarah Pagano ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Serum Insulin ◽  
Serum Markers ◽  
Serum Creatine Kinase ◽  
Skeletal Muscle Regeneration ◽  
Skeletal Muscle Damage ◽  
Leg Strength ◽  
Exercise Induced

Physical performance and regeneration after exercise is enhanced by the ingestion of proteins and carbohydrates. These nutrients are generally consumed by athletes via whey protein and glucose-based shakes. In this study, effects of protein and carbohydrate on skeletal muscle regeneration, given either by shake or by a meal, were compared. 35 subjects performed a 10 km run. After exercise, they ingested nothing (control), a protein/glucose shake (shake) or a combination of white bread and sour milk cheese (food) in a randomized cross over design. Serum glucose (n = 35), serum insulin (n = 35), serum creatine kinase (n = 15) and myoglobin (n = 15), hematologic parameters, cortisol (n = 35), inflammation markers (n = 27) and leg strength (n = 15) as a functional marker were measured. Insulin secretion was significantly stimulated by shake and food. In contrast, only shake resulted in an increase of blood glucose. Food resulted in a decrease of pro, and stimulation of anti-inflammatory serum markers. The exercise induced skeletal muscle damage, indicated by serum creatine kinase and myoglobin, and exercise induced loss of leg strength was decreased by shake and food. Our data indicate that uptake of protein and carbohydrate by shake or food reduces exercise induced skeletal muscle damage and has pro-regenerative effects.

Enzymatic estimation of skeletal muscle damage by analysis of changes in serum creatine kinase

1988 ◽  
Vol 65 (6) ◽  
pp. 2598-2600 ◽  
Author(s):  
F. S. Apple ◽  
M. Rhodes
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Myocardial Infarct ◽  
Serum Creatine Kinase ◽  
Myocardial Infarct Size ◽  
Distribution Space ◽  
Skeletal Muscle Damage ◽  
Significant Difference ◽  
Theoretical Results

Skeletal muscle damage size (SMDS) was assessed in 35 women and 34 men runners after a 42.2-km race using a method developed for estimation of myocardial infarct size. SMDS was computed according to the following equation: SMDS = (BW) (K) (CKr), where BW is body weight, K is a constant, and CKr is the cumulative amount of creatine kinase (CK) released over time. The method takes into account CK distribution space, fractional disappearance rate of CK, proportion of CK degraded in skeletal muscle, and proportion of CK released into the circulation. Assumptions are made regarding the relative amount of CK lost from skeletal muscle into the circulation. The SMDS in men, 808 +/- 1,229 (SD) CK g-eq was significantly (P less than 0.05) greater than in women, 160 +/- 147 (SD) CK g-eq. The ranges of SMDS (CK g-eq) were 23-5,397 in men and 7-624 in women. A significant difference (P less than 0.05) also remained after correction for body surface area; men 432 +/- 583 (SD), women 100 +/- 63 (SD) CK g-eq/m2. In men and women, no significant correlation existed between SMDS and age or marathon finish time. Although relatively theoretical, results indicate that greater skeletal muscle damage occurred in men vs. women runners after a marathon. Whether the release of CK from skeletal muscle is the result of irreversible and/or reversible injury has not yet been determined.

Isoforms of creatine kinase: MM in the study of skeletal muscle damage

1989 ◽  
Vol 19 (2) ◽  
pp. 185-191 ◽  
Author(s):  
S. PAGE ◽  
M. J. JACKSON ◽  
J. COAKLEY ◽  
R. H. T. EDWARDS
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Muscle Damage ◽  
Skeletal Muscle Damage

scholarly journals Fast skeletal troponin I, but not the slow isoform, is increased in patients under statin therapy: a pilot study

2018 ◽  
Vol 29 (1) ◽  
pp. 68-76
Author(s):  
Alessandro Trentini ◽  
Maria C Manfrinato ◽  
Tiziana Bellini ◽  
Carlo A Volta ◽  
Stefania Hanau ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Statin Therapy ◽  
Muscle Damage ◽  
Troponin I ◽  
Academic Hospital ◽  
Creatine Kinase Mb ◽  
The University ◽  
Fast Twitch ◽  
Muscular Damage

Introduction: Statin therapy is often associated with muscle complaints and increased serum creatine kinase (CK). However, although essential in determining muscle damage, this marker is not specific for skeletal muscle. Recent studies on animal models have shown that slow and fast isoforms of skeletal troponin I (ssTnI and fsTnI, respectively) can be useful markers of skeletal muscle injury. The aim of this study was to evaluate the utility of ssTnI and fsTnI as markers to monitor the statin-induced skeletal muscle damage. Materials and methods: A total of 51 patients (14 using and 37 not using statins) admitted to the intensive care unit of the University of Ferrara Academic Hospital were included in this observational study. Serum activities of CK, aldolase, alanine aminotransferase and myoglobin were determined by spectrophotometric assays or routine laboratory analysis. Isoforms ssTnI and fsTnI were determined by commercially available ELISAs. The creatine kinase MB isoform (CK-MB) and cardiac troponin I (cTnI) were evaluated as biomarkers of cardiac muscle damage by automatic analysers. Results: Among the non-specific markers, only CK was significantly higher in statin users (P = 0.027). Isoform fsTnI, but not ssTnI, was specifically increased in those patients using statins (P = 0.009) evidencing the major susceptibility of fast-twitch fibres towards statins. Sub-clinical increase in fsTnI, but not CK, was more frequent in statin users (P = 0.007). Cardiac markers were not significantly altered by statins confirming the selectivity of the effect on skeletal muscle. Conclusions: Serum fsTnI could be a good marker for monitoring statin-associated muscular damage outperforming traditional markers.

Detection of muscle-specific creatine kinase expression as physiological indicator for Atlantic salmon (Salmo salar L) skeletal muscle damage

Aquaculture ◽  
2018 ◽  
Vol 496 ◽  
pp. 66-72 ◽  
Author(s):  
Verónica Rojas ◽  
Byron Morales-Lange ◽  
Rubén Avendaño-Herrera ◽  
Matías Poblete-Morales ◽  
Diana Tapia-Cammas ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Atlantic Salmon ◽  
Muscle Damage ◽  
Salmo Salar ◽  
Skeletal Muscle Damage ◽  
Atlantic Salmon Salmo Salar ◽  
Kinase Expression ◽  
Physiological Indicator

scholarly journals Transient Creatine Kinase Elevation Followed by Hypocomplementemia in a Case of Rotavirus Myositis

2016 ◽  
Vol 2016 ◽  
pp. 1-2
Author(s):  
Yuka Rokugo ◽  
Satoru Kumaki ◽  
Ryoichi Onuma ◽  
Rie Noguchi ◽  
Saeko Suzuki ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Creatine Kinase ◽  
Case Report ◽  
Serum Albumin ◽  
Muscle Damage ◽  
Complement Activation ◽  
Rare Complication ◽  
Serum Creatine Kinase ◽  
Skeletal Muscle Damage ◽  
Infant Case

We report an infant case of rotavirus myositis, a rare complication of rotavirus infection. Complement levels of the patient were normal when serum creatine kinase (CK) level was at its peak and then decreased when the CK level became normalized. In a previous case report of rotavirus myositis, transient decrease of serum albumin, immunoglobulin, and complement levels was reported. The authors speculated that intravascular complement activation was caused by rotavirus and resulted in the pathogenesis of myositis, although complement levels at onset were not measured by the authors. In this report, however, we demonstrate that the complement activation of our patient is a result of, rather than the cause of, skeletal muscle damage.

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