scholarly journals Classification of Lung Carcinomas in the Dog and Cat

1981 ◽  
Vol 18 (4) ◽  
pp. 513-528 ◽  
Author(s):  
J. E. Moulton ◽  
C. Von Tscharner ◽  
R. Schneider
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Large Cell ◽  
Cell Types ◽  
Small Cell ◽  
Alveolar Cell ◽  
Lung Carcinomas ◽  
Gland Carcinoma ◽  
Bronchial Gland

A total of 218 lung carcinomas from dogs and cats were examined histologically. The tumors were classified into adenocarcinoma, squamous-cell carcinoma, bronchial gland carcinoma, and alveolar-cell carcinoma. We believe that adenocarcinoma should be subdivided into differentiated and undifferentiated types because the two are distinct histologically and vary in frequency in the cat and dog. It is also important to recognize bronchial gland carcinoma, a distinct histological type, and to subdivide alveolar-cell carcinoma into three separate types: anaplastic small-cell and large-cell types, and adenomatosis type.

Synchronous Triple Carcinoma of the Lung in One Patient

1987 ◽  
Vol 73 (5) ◽  
pp. 525-529 ◽  
Author(s):  
Paolo Badiali ◽  
Marco Alloisio ◽  
Luciano Lombardi
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Lower Lobe ◽  
Small Cell ◽  
Simultaneous Occurrence ◽  
Lung Carcinomas ◽  
The Right ◽  
Common Cell

A case is reported of the simultaneous occurrence of a squamous cell carcinoma and a small cell carcinoma, both centrally located, in the right upper lobe and a peripheral adenocarcinoma in the right lower lobe. The simultaneous occurrence of three primary lung carcinomas is discussed in the light of a probable common cell origin.

Lung Cancer - Part I

2019 ◽  
Author(s):  
Jeffrey Crawford ◽  
John Strickler
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Small Cell Lung

In the United States, lung cancer is the second most common cancer, surpassed only by prostate cancer in men and breast cancer in women. But lung cancer is the leading cause of cancer deaths, accounting for 29% and 26% of all cancer-related deaths in men and women, respectively. The four major pathologic cell types of lung cancer are small cell carcinoma, adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Because they have overlapping clinical behaviors and responses to treatment, adenocarcinoma, squamous cell carcinoma, and large cell carcinoma are generally grouped together in the category of non–small cell lung cancer (NSCLC). This review discusses both NSCLC and small cell lung cancer (SCLC), including lung cancer in those who have never smoked, prevention of lung cancer, with sections on diagnosis, biomarkers, treatment, and supportive care.  This review contains 7 figures, 10 tables, and 74 references. Keywords: lung cancer, mediastinoscopy, chemoradiotherapy, TNM staging system, pulmonary parenchyma, segmentectomy

α-Methylacyl CoA Racemase in Pulmonary Adenocarcinoma, Squamous Cell Carcinoma, and Neuroendocrine Tumors: Expression and Survival Analysis

2007 ◽  
Vol 131 (10) ◽  
pp. 1555-1560
Author(s):  
Konstantin Shilo ◽  
Tatiana Dracheva ◽  
Haresh Mani ◽  
Junya Fukuoka ◽  
Isabell A. Sesterhenn ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lung Carcinoma ◽  
Small Cell Lung Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Stage I ◽  
Small Cell Lung ◽  
Cell Lung Carcinoma

Abstract Context.—α-Methylacyl CoA racemase (AMACR) is an oxidative enzyme involved in isomeric transformation of fatty acids entering the beta-oxidation pathway. AMACR serves as a useful marker in establishing a diagnosis of prostatic malignancy; however, limited information is available in regard to its presence in pulmonary neoplasms. Objective.—To investigate AMACR expression within a spectrum of lung carcinomas and its correlation with patients' survival. Design.—Four hundred seventy-seven pulmonary carcinomas, including 150 squamous cell carcinomas, 150 adenocarcinomas, 46 typical carcinoids, 31 atypical carcinoids, 28 large cell neuroendocrine carcinomas, and 72 small cell carcinomas, were studied immunohistochemically using tissue microarray–based samples. Results.—Overall, pulmonary tumors were positive for AMACR in a significant percentage (47%) of cases. Among tumor types, 22% of squamous cell carcinoma, 56% of adenocarcinoma, 72% of typical carcinoid, 52% of atypical carcinoid, 70% of large cell neuroendocrine carcinoma, and 51% of small cell lung carcinoma were positive for AMACR. Furthermore, the Kaplan-Meier analysis revealed that the patients with AMACR-positive small cell carcinoma had better survival (19% vs 5% after 5 years, P = .04) than patients with AMACR-negative tumors. Such survival advantage was seen for patients with stage I–II (P = .01) but not stage III–IV small cell carcinomas (P = .58). Conclusions.—These results indicate that, similar to prostate cancer, the overexpression of AMACR frequently occurs in pulmonary carcinomas. Additionally, its positive correlation with outcome of stage I–II small cell lung carcinoma warrants further investigation of the AMACR role in the prognosis of this tumor.

Lung Cancer - Part I

2019 ◽  
Author(s):  
Jeffrey Crawford ◽  
John Strickler
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Small Cell Lung

In the United States, lung cancer is the second most common cancer, surpassed only by prostate cancer in men and breast cancer in women. But lung cancer is the leading cause of cancer deaths, accounting for 29% and 26% of all cancer-related deaths in men and women, respectively. The four major pathologic cell types of lung cancer are small cell carcinoma, adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Because they have overlapping clinical behaviors and responses to treatment, adenocarcinoma, squamous cell carcinoma, and large cell carcinoma are generally grouped together in the category of non–small cell lung cancer (NSCLC). This review discusses both NSCLC and small cell lung cancer (SCLC), including lung cancer in those who have never smoked, prevention of lung cancer, with sections on diagnosis, biomarkers, treatment, and supportive care.  This review contains 7 figures, 10 tables, and 74 references. Keywords: lung cancer, mediastinoscopy, chemoradiotherapy, TNM staging system, pulmonary parenchyma, segmentectomy

Lung Cancer Part II

2019 ◽  
Author(s):  
Jeffrey Crawford
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Small Cell Lung Cancer ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Lung Cancer ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Small Cell Lung

In the United States, lung cancer is the second most common cancer, surpassed only by prostate cancer in men and breast cancer in women. But lung cancer is the leading cause of cancer deaths, accounting for 29% and 26% of all cancer-related deaths in men and women, respectively. The four major pathologic cell types of lung cancer are small cell carcinoma, adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. Because they have overlapping clinical behaviors and responses to treatment, adenocarcinoma, squamous cell carcinoma, and large cell carcinoma are generally grouped together in the category of non–small cell lung cancer (NSCLC). This review discusses treatment of both NSCLC and small cell lung cancer (SCLC). This review 2 figures, 19 tables, and 90 references. Keywords: lung cancer, mediastinoscopy, chemoradiotherapy, TNM staging system, pulmonary parenchyma, segmentectomy

scholarly journals Histologic variants of urothelial bladder cancer and nonurothelial histology in bladder cancer

2013 ◽  
Vol 3 (6-S4) ◽  
pp. 193 ◽  
Author(s):  
Venu Chalasani ◽  
Joseph L. Chin ◽  
Jonathan I. Izawa
Keyword(s):  
Squamous Cell Carcinoma ◽  
Bladder Cancer ◽  
Cell Carcinoma ◽  
Urothelial Cancer ◽  
Small Cell ◽  
Urothelial Bladder Cancer ◽  
Divergent Differentiation ◽  
Urothelial Bladder ◽  
Worse Prognosis

Bladder cancer can be classified histologically as urothelial ornon-urothelial. Urothelial cancer has a propensity for divergentdifferentiation, which has increasingly been recognized in recentyears due to heightened awareness and improved immunohistochemistrytechniques. Furthermore, the recent World HealthOrganization classification of urothelial cancers improved clarityon this issue, with its listing of 13 histologic variants of urothelialcancer. The divergent differentiation patterns include, amongstothers, squamous, glandular, micropapillary, nested, lymphepithelioma-like, plasmacytoid and sarcomatoid variants of urothelialcancer. Attempts to quantify the amount of divergent differentiationpresent, such as using the nonconventional differentiationnumber, have been made recently, which will improve the abilityto compare publications from different centres. Genetic-basedstudies have indicated that the histologic variants of urothelialcancer arise from a common clonal precursor. Mostly, the currentevidence suggests that urothelial cancer with divergent differentiationhas a worse prognosis when compared with pure urothelialcancer. This article will review the current literature on varianthistologies of urothelial cancer, and well as new developmentsin pure squamous cell carcinoma, small cell carcinoma and adenocarcinomaof the bladder.

scholarly journals A 2-year retrospective review of the effect of cigarette smoking status on the histological cell types of lung carcinoma in the Western Cape

2015 ◽  
Vol 21 (2) ◽  
pp. 23
Author(s):  
A S Pellizzon ◽  
C F N Koegelenberg ◽  
E M Irusen
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cigarette Smoking ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Smoking Status ◽  
Cell Types ◽  
Small Cell ◽  
Western Cape ◽  
Significant Difference

<p><strong>Background.</strong> Cigarette smoking is variably associated with the various histological cell types of lung cancer. The primary aim of this study was to analyse various strengths of association between the common histological cell types of lung cancer and smoking in a Western Cape population. The secondary aim examined whether an association exists between scar carcinoma and smoking.</p><p><strong>Methods</strong>. We retrospectively analysed the records from 386 patients over a 2-year period. Both smokers and non-smokers were subdivided and analysed as two groups, which included those with non-small cell and small cell lung cancer. Smokers and non-smokers were also analysed separately according to the presence or absence of lung scarring.</p><p><strong>Results.</strong> In total, 94.3% of all patients with lung cancer were current or past smokers. There was a disproportionately higher number of patients with adenocarcinoma who were non-smokers compared with all the other cell types (<strong>p</strong>=0.01), whereas patients with squamous cell carcinoma were more likely to be smokers (<strong>p</strong>=0.05). Although the vast majority of patients with and without lung scars were found to be smokers (96.4% v. 93.7% respectively), there was no statistically significant difference found between these two groups (<strong>p</strong>=0.43).</p><p><strong>Conclusion</strong>. In a Western Cape population, patients with adenocarcinoma were more likely to be non-smokers, while those with squamous cell carcinoma were relatively more likely to be smokers. No clear association between scar carcinoma and smoking status was found.</p>

scholarly journals Das anaplastische Lungenkarzinom des Hundes

1973 ◽  
Vol 10 (2) ◽  
pp. 102-113 ◽  
Author(s):  
H. Stünzi
Keyword(s):  
Cell Carcinoma ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Domestic Animals ◽  
Small Cell ◽  
Round Cell ◽  
Histological Criteria ◽  
Pulmonary Tumors ◽  
Pulmonary Neoplasia

Of 86 canine pulmonary tumors five had the histological criteria of undifferentiated small-cell carcinoma and two of undifferentiated large-cell carcinoma. The five small-cell anaplastic careinomas could be divided, as is the case in man, according to strict histological criteria into fusiform, lymphocyte-like, and polygonal subgroups. In the fusiform and round-cell subgroups there were focal sites of equivocal differentiation towards epidermoid careinoma or adenocarcinoma. These local changes must be considered in making a diagnosis, but it was not possible to positively determine the behavior of anaplastic, epidermoid or glandular carcinomas. The classification of pulmonary carcinomas of domestic animals has significance not only for experimental oncology but also for clarification of the cause of pulmonary neoplasia. Anaplastic pulmonary carcinomas have not been found in the cat.

Identification of potential serum biomarkers for simultaneously classifying lung adenocarcinoma, squamous cell carcinoma and small cell carcinoma

2020 ◽  
pp. 1-12
Author(s):  
Jiangqing Yu ◽  
Fen Du ◽  
Liping Yang ◽  
Ling Chen ◽  
Yuanxiang He ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Small Cell ◽  
Serum Biomarkers ◽  
Stepwise Discriminant Analysis ◽  
Mlp Model

BACKGROUND: Histological subtypes of lung cancer are crucial for making treatment decisions. However, multi-subtype classifications including adenocarcinoma (AC), squamous cell carcinoma (SqCC) and small cell carcinoma (SCLC) were rare in the previous studies. This study aimed at identifying and screening potential serum biomarkers for the simultaneous classification of AC, SqCC and SCLC. PATIENTS AND METHODS: A total of 143 serum samples of AC, SqCC and SCLC were analyzed by 1HNMR and UPLC-MS/MS. The stepwise discriminant analysis (DA) and multilayer perceptronMLPwere employed to screen the most efficient combinations of markers for classification. RESULTS: The results of non-targeted metabolomics analysis showed that the changes of metabolites of choline, lipid or amino acid might contribute to the classification of lung cancer subtypes. 17 metabolites in those pathways were further quantified by UPLC-MS/MS. DA screened out that serum xanthine, S-Adenosyl methionine (SAM), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE) and squamous cell carcinoma antigen (SCC) contributed significantly to the classification of AC, SqCC and SCLC. The average accuracy of 92.3% and the area under the receiver operating characteristic curve of 0.97 would be achieved by MLP model when a combination of those five variables as input parameters. CONCLUSION: Our findings suggested that metabolomics was helpful in screening potential serum markers for lung cancer classification. The MLP model established can be used for the simultaneous diagnosis of AC, SqCC and SCLC with high accuracy, which is worthy of further study.

scholarly journals Primary neuroendocrine neoplasm of the esophagus – Report of 14 cases from a single institute and review of the literature

2017 ◽  
Vol 54 (1) ◽  
pp. 4-10 ◽  
Author(s):  
Francisco TUSTUMI ◽  
Flavio Roberto TAKEDA ◽  
Rodrigo Hideki UEMA ◽  
Guilherme Luiz Stelko PEREIRA ◽  
Rubens Antonio Aissar SALLUM ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Neuroendocrine Tumors ◽  
Squamous Cell ◽  
Large Cell ◽  
Small Cell ◽  
Esophageal Neoplasm ◽  
Neuroendocrine Neoplasm ◽  
High Grade ◽  
Esophageal Tumors

ABSTRACT BACKGROUND Most prevalent esophageal neoplasm is squamous cell carcinoma and adenocarcinoma. Other tumors are uncommon and poorly studied. Primary neuroendocrine esophageal neoplasm is a rare carcinoma and most of its therapy management is based on lung neuroendocrine studies. Neuroendocrine tumors can be clustered in the following subtypes: high grade (small cell carcinoma or large cell carcinoma) and low grade (carcinoids). OBJECTIVE The present study aims to assess clinical and pathological neuroendocrine esophageal tumors in a single oncologic center. METHODS A retrospective analysis of patients and review of the literatures was performed. RESULTS Fourteen patients were identified as neuroendocrine tumors, 11 male and 3 female patients. Mean age was 67.3 years old. Ten patients were classified as small cell, 3 as large cell and 1 as carcinoid. Four patients presented squamous cell carcinoma simultaneously and 1 also presented adenocarcinoma. Main sites of metastasis were liver, peritoneum, lung and bones. Most patients died before 2 years of follow-up. Patient with longer survival died at 35 months after diagnosis. CONCLUSION Neuroendocrine esophageal tumors are rare; affect mainly men in their sixties or seventies. High grade tumors can be mixed to other subtypes neoplasms, such as adenocarcinoma and squamous cell carcinoma. Most of these patients have poor overall survival rates.

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