Hydrodynamic Function of a Biostable Polyurethane Flexible Heart Valve after Six Months in Sheep

2001 ◽  
Vol 24 (2) ◽  
pp. 95-101 ◽  
Author(s):  
D.J. Wheatley ◽  
G.M. Bernacca ◽  
M.M. Tolland ◽  
B. O'connor ◽  
J. Fisher ◽  
...  
Keyword(s):  
Heart Valve ◽  
Hydrodynamic Function

scholarly journals TCT-823 In-Vitro Assessment Of The Influence Of Oval Annuli On The Hydrodynamic Function Of Percutaneous Heart Valve Prostheses

2012 ◽  
Vol 60 (17) ◽  
pp. B239
Author(s):  
Maximilian Kuetting ◽  
Alexander Sedaghat ◽  
Marc Utzenrath ◽  
Christoph Schmitz ◽  
Nikos Werner ◽  
...  
Keyword(s):  
Heart Valve ◽  
Heart Valve Prostheses ◽  
In Vitro Assessment ◽  
Valve Prostheses ◽  
Percutaneous Heart Valve ◽  
Hydrodynamic Function

The Influence of Manufacturing Methods on the Function and Performance of a Synthetic Leaflet Heart Valve

1995 ◽  
Vol 209 (1) ◽  
pp. 65-69 ◽  
Author(s):  
M E Leat ◽  
J Fisher
Keyword(s):  
Heart Valve ◽  
Heart Valves ◽  
The Body ◽  
Ventricular Assist Devices ◽  
Ventricular Assist ◽  
Thermal Forming ◽  
Manufacturing Methods ◽  
And Performance ◽  
Hydrodynamic Function

There is considerable interest in polyurethane synthetic leaflet heart valves for both ventricular assist devices and direct implantation in the body. Two different manufacturing methods, thermal forming, and dip casting, of the leaflets have been investigated. There were only small differences in the hydrodynamic function of the valves made by the two methods. However, the durability of dip cast valves was far superior to the thermally formed film fabricated leaflets, with all of the dip cast valves reaching 160 million cycles without failure. This study indicates that a correctly designed and manufactured polyurethane synthetic leaflet heart valve has the potential for long-term implantation in the body.

Polyurethane Heart Valve Durability: Effects of Leaflet Thickness and Material

1997 ◽  
Vol 20 (6) ◽  
pp. 327-331 ◽  
Author(s):  
G.M. Bernacca ◽  
T.G. Mackay ◽  
M.J. Gulbransen ◽  
A.W. Donn ◽  
D.J. Wheatley
Keyword(s):  
Fatigue Test ◽  
Heart Valve ◽  
Major Determinant ◽  
Clinical Use ◽  
Hydrodynamic Properties ◽  
Varying Thickness ◽  
Hydrodynamic Function

A flexible trileaflet polyurethane valve has been made by dip-moulding leaflets directly onto an injection-moulded frame. The durability of this valve is, in part, determined by the thickness of its leaflets. Leaflet thickness is also a major determinant of hydrodynamic function. This study examines valves (n=31) with leaflets made of a polyetherurethane (PEU, n = 22) or a polyetherurethaneurea (PEUE, n = 9), of varying thickness distributions. The valves were subjected to accelerated fatigue test at 37°C and failure monitored. Leaflet thicknesses ranged from 60 to 200 μm. PEU leaflet thickness bore no relationship to durability, which was less than 400 million cycles. PEUE valves, in contrast, exceeded 800 million cycles. Durability in PEUE valves was directly related to leaflet thickness (r = 0.93, p < 0.001), with good durability achieved with median leaflet thicknesses of approximately 150μm. Thus polyurethane valves can be made with good hydrodynamic properties and with sufficient durability to consider potential clinical use.

Choosing A Prosthetic Heart Valve

1991 ◽  
Vol 9 (2) ◽  
pp. 329-338 ◽  
Author(s):  
Jorge A. Wernly ◽  
Michael H. Crawford
Keyword(s):  
Heart Valve ◽  
Prosthetic Heart Valve

Impact of protein coating strategies on the re-endothelialization of biological heart valve scaffolds

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
P Akhyari ◽  
H Ziegler ◽  
P Mambou ◽  
M Barth ◽  
S Hoffmann ◽  
...  
Keyword(s):  
Heart Valve ◽  
Protein Coating

Biological heart valve prosthesis in patients requiring chronic dialysis

2009 ◽  
Vol 56 (S 01) ◽  
Author(s):  
A Böning ◽  
S Haberer ◽  
UP Rosendahl ◽  
I Florath ◽  
JC Ennker
Keyword(s):  
Heart Valve ◽  
Chronic Dialysis ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis

Transcatheter aortic heart valve (THV) implantation of Edwards Sapien™ bioprothesis – using a mobile x-ray-system or a hybrid-OR?

2010 ◽  
Vol 58 (S 01) ◽  
Author(s):  
H Schröfel ◽  
G Schymik ◽  
A Würth ◽  
V Elsner ◽  
BD Gonska ◽  
...  
Keyword(s):  
Heart Valve ◽  
X Ray ◽  
Aortic Heart Valve ◽  
Edwards Sapien

A Comparison of a Moderate with Moderate-high Intensity Oral Anticoagulant Treatment in Patients with Mechanical Heart Valve Prostheses

1997 ◽  
Vol 77 (05) ◽  
pp. 0839-0844 ◽  
Author(s):  
Vittorio Pengo ◽  
Fabio Barbero ◽  
Alberto Banzato ◽  
Elisabetta Garelli ◽  
Franco Noventa ◽  
...  
Keyword(s):  
Heart Valve ◽  
High Intensity ◽  
Oral Anticoagulant ◽  
Oral Anticoagulants ◽  
Mechanical Heart Valve ◽  
Moderate Intensity ◽  
Minor Bleeding ◽  
Anticoagulant Treatment ◽  
Oral Anticoagulant Treatment ◽  
Valve Prostheses

SummaryBackground. The long-term administration of oral anticoagulants to patients with mechanical heart valve prostheses is generally accepted. However, the appropriate intensity of oral anticoagulant treatment in these patients is still controversial.Methods and Results. From March 1991 to March 1994, patients referred to the Padova Thrombosis Center who had undergone mechanical heart valve substitution at least 6 months earlier were randomly assigned to receive oral anticoagulants at moderate intensity (target INR = 3) or moderate-high intensity (target INR = 4). Principal end points were major bleeding, thromboembolism and vascular death. Minor bleeding was a secondary end-point.A total of 104 patients were assigned to the target 3 group and 101 to the target 4 group; they were followed for from 1.5 years to up 4.5 years (mean, 3 years). Principal end-points occurred in 13 patients in the target 3 group (4 per 100 patient-years) and in 20 patients in the target 4 group (6.9 per 100 patient-years). Major hemorrhagic events occurred in 15 patients, 4 in the target 3 group (1.2 per 100 patient-years) and 11 in the target 4 group (3.8 per 100 patient-years) (p = 0.019). The 12 recorded episodes of thromboembolism, 4 of which consisted of a visual deficit, were all transient ischemic attacks, 6 in the target 3 group (1.8 per 100 patient-years) and 6 in the target 4 group (2.1 per 100 patient- years). There were 3 vascular deaths in each group (0.9 and 1 per 100 patient-years for target 3 and target 4 groups, respectively). Minor bleeding episodes occurred 85 times (26 per 100 patient-years) in the target 3 group and 123 times (43 per 100 patient-years) in the target 4 group (p = 0.001).Conclusions. Mechanical heart valve patients on anticoagulant treatment who had been operated on at least 6 months earlier experienced fewer bleeding complications when maintained on a moderate intensity regimen (target INR = 3) than those on a moderate-high intensity regimen (target INR = 4). The number of thromboembolic events and vascular deaths did not differ between the two groups.

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