Prophylactic use of intravenous prostaglandin E1 for radial arterial spasm in uremic patients undergoing construction of arteriovenous hemodialysis fistulas

1994 ◽  
Vol 17 (10) ◽  
pp. 511-514 ◽  
Author(s):  
A. Owada ◽  
H. Saito ◽  
T. Nagai ◽  
H. Iwamoto ◽  
T. Shiigai
Keyword(s):  
Blood Flow ◽  
Arterial Blood Flow ◽  
Prostaglandin E ◽  
Hemodialysis Access ◽  
Arterial Spasm ◽  
Doppler Flowmetry ◽  
Arterial Blood ◽  
Uremic Patients ◽  
Prophylactic Use ◽  
Hemodialysis Fistulas

Radial arterial spasm in uremic patients undergoing construction of internal arteriovenous (AV) dialysis fistulas was investigated transcutaneously using ultrasonic Doppler flowmetry. In 6 of 16 control patients, the radial arterial blood flow was significantly decreased for 20 min after anastomosing, indicating vasospasm. Vasospasm did not occur in 15 patients who were continuously administered prostaglandin E1 (PGE1) intravenously (10 ng/kg/min) during surgery. The arterial blood flow was significantly increased in patients receiving PGE1 in comparison with control patients not receiving PGE1 and in whom vasospasm did not occur. Regarding patency of hemodialysis access, the fistula was obstructed in one control patient with radial arterial spasm, but not in patients with PGE1 infusion. Our study suggests that PGE1 may be effective in preventing vasospasm in patients undergoing placement of internal AV dialysis fistulas.

Comparison of plethysmographic methods with pulsed Doppler blood flowmetry

1979 ◽  
Vol 236 (6) ◽  
pp. H899-H903 ◽  
Author(s):  
B. I. Levy ◽  
W. R. Valladares ◽  
A. Ghaem ◽  
J. P. Martineaud
Keyword(s):  
Blood Flow ◽  
Strain Gauge ◽  
Venous Occlusion ◽  
Arterial Blood Flow ◽  
Pulsed Doppler ◽  
Local Cooling ◽  
Doppler Flowmetry ◽  
Strain Gauge Plethysmography ◽  
Arterial Blood ◽  
Local Warming

Hand blood flow was measured at rest, with local warming, and with local cooling. Three methods were simultaneously used: water plethysmography (WP), mercury-in-rubber strain gauge plethysmography (SG), and pulsed Doppler flowmetry (D). Of these, water plethysmography is the most sensitive and accurate; strain gauge plethysmography is simpler but less accurate; and pulsed Doppler flowmetry precisely measures instantaneous arterial blood flow without venous occlusion.

Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase

2003 ◽  
Vol 90 (07) ◽  
pp. 64-70 ◽  
Author(s):  
J. Kent Leach ◽  
Eugene Patterson ◽  
Yiwei Miao ◽  
Arthur Johnson ◽  
Edgar O’Rear
Keyword(s):  
Blood Flow ◽  
Carotid Artery ◽  
Rabbit Model ◽  
Water Soluble ◽  
Arterial Blood Flow ◽  
Doppler Flowmetry ◽  
Carotid Artery Thrombosis ◽  
Arterial Blood ◽  
Artery Thrombosis ◽  
Autologous Whole Blood

SummaryThe present study compares the efficacy of two formulations of encapsulated streptokinase to streptokinase in a rabbit model of carotid artery thrombosis. Arterial thrombosis followed the injection of thrombin mixed with autologous whole blood into a carotid artery of New Zealand white rabbits. Thirty minutes after the confirmation of an occlusive thrombus, one of four streptokinase formulations was infused at a dosage of 6,000 IU/kg into the jugular vein. Free streptokinase (FREE SK) was compared to identical dosages of streptokinase encapsulated in a liposome (LESK), streptokinase entrapped in a water-soluble polymer (MESK), and free streptokinase admixed with blank microparticles (FREE SK + BLANK). Carotid arterial blood flow was determined by pulsed Doppler flowmetry to confirm clot formation and reperfusion. Two hours after drug infusion, the rabbits were killed and the residual thrombus mass was determined.Compared to FREE SK (74.5 ± 16.9 min; mean ± SEM), LESK demonstrated significantly reduced reperfusion times (19.3 ± 4.6 min) while MESK exhibited even greater improvement (7.3 ± 1.6 min). FREE SK + BLANK showed no statistical improvement versus FREE SK. LESK and MESK also resulted in reduced residual clot mass and greater return of arterial blood flow. These studies suggest that encapsulation of streptokinase offers a potential method of improved fibrinolytic treatment for patients with clot-based disorders. MESK performed slightly better than LESK with improved production and storage characteristics.

scholarly journals Laser Doppler Flowmetry to Differentiate Arterial From Venous Occlusion in Free Tissue Transfer

2019 ◽  
Vol 27 (4) ◽  
pp. 297-304
Author(s):  
Emre Gazyakan ◽  
Huang-Kai Kao ◽  
Ming-Huei Cheng ◽  
Holger Engel
Keyword(s):  
Blood Flow ◽  
Laser Doppler Flowmetry ◽  
Free Tissue Transfer ◽  
Venous Occlusion ◽  
Laser Doppler ◽  
Arterial Blood Flow ◽  
Probe Laser ◽  
Doppler Flowmetry ◽  
Arterial Blood ◽  
Tissue Transfer

Purpose: The differentiation of arterial versus venous occlusion in free tissue transfers has rarely been described. This study investigated changes in blood flow caused by arterial and venous occlusion and the potential for laser Doppler flowmetry to distinguish between these 2 conditions for better clinical assessment and management of free tissue transfer. Methods: Six patients with a mean age of 43.5 years underwent microsurgical free tissue transfer. The venous and arterial blood flow of the vessels and skin flap were monitored using laser Doppler flowmetry with high-frequency pulsed Doppler transducers for vessels and skin before, during, and after clamping the vessels for 10 minutes. Results: The average decreases in blood flow in the artery and vein caused by clamping were 94.4% and 93.8%, respectively. On average, arterial occlusion demonstrated a sudden drop of 67.7% and venous occlusion caused a decrease of 26.6% on laser Doppler flowmetry in free tissue skin. Conclusion: Using a vessel-holding probe, laser Doppler flowmetry could be used to differentiate between arterial and venous occlusion in free tissue transfer, thereby aiding decision-making for better clinical management.

Modeling Elastic Walls in Lattice Boltzmann Simulations of Arterial Blood Flow

2013 ◽  
Vol 23 (2) ◽  
Author(s):  
Xenia Descovich ◽  
Giuseppe Pontrelli ◽  
Sauro Succi ◽  
Simone Melchionna ◽  
Manfred Bammer
Keyword(s):  
Blood Flow ◽  
Lattice Boltzmann ◽  
Arterial Blood Flow ◽  
Arterial Blood ◽  
Lattice Boltzmann Simulations ◽  
Elastic Walls

scholarly journals Sustained Inflation Reduces Pulmonary Blood Flow during Resuscitation with an Intact Cord

Children ◽  
2021 ◽  
Vol 8 (5) ◽  
pp. 353
Author(s):  
Jayasree Nair ◽  
Lauren Davidson ◽  
Sylvia Gugino ◽  
Carmon Koenigsknecht ◽  
Justin Helman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Perinatal Asphyxia ◽  
Arterial Blood Flow ◽  
Positive Pressure ◽  
Optimal Timing ◽  
Delayed Cord Clamping ◽  
Arterial Blood ◽  
Cord Clamping ◽  
Sustained Inflation ◽  
Near Term

The optimal timing of cord clamping in asphyxia is not known. Our aims were to determine the effect of ventilation (sustained inflation–SI vs. positive pressure ventilation–V) with early (ECC) or delayed cord clamping (DCC) in asphyxiated near-term lambs. We hypothesized that SI with DCC improves gas exchange and hemodynamics in near-term lambs with asphyxial bradycardia. A total of 28 lambs were asphyxiated to a mean blood pressure of 22 mmHg. Lambs were randomized based on the timing of cord clamping (ECC—immediate, DCC—60 s) and mode of initial ventilation into five groups: ECC + V, ECC + SI, DCC, DCC + V and DCC + SI. The magnitude of placental transfusion was assessed using biotinylated RBC. Though an asphyxial bradycardia model, 2–3 lambs in each group were arrested. There was no difference in primary outcomes, the time to reach baseline carotid blood flow (CBF), HR ≥ 100 bpm or MBP ≥ 40 mmHg. SI reduced pulmonary (PBF) and umbilical venous (UV) blood flow without affecting CBF or umbilical arterial blood flow. A significant reduction in PBF with SI persisted for a few minutes after birth. In our model of perinatal asphyxia, an initial SI breath increased airway pressure, and reduced PBF and UV return with an intact cord. Further clinical studies evaluating the timing of cord clamping and ventilation strategy in asphyxiated infants are warranted.

Incidence and risk factors of early arterial blood flow stasis during first radioembolization of primary and secondary liver malignancy using resin microspheres: an initial single-center analysis

2015 ◽  
Vol 26 (8) ◽  
pp. 2779-2789 ◽  
Author(s):  
Claus Christian Pieper ◽  
Winfried A. Willinek ◽  
Daniel Thomas ◽  
Hojjat Ahmadzadehfar ◽  
Markus Essler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Flow ◽  
Arterial Blood Flow ◽  
Single Center ◽  
Liver Malignancy ◽  
Arterial Blood ◽  
Resin Microspheres ◽  
Flow Stasis
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