Reduction of Platelet Trapping in Membrane Oxygenators by Transmembraneous Application of Gaseous Nitric Oxide
1996 ◽
Vol 19
(5)
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pp. 291-293
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Keyword(s):
Bleeding during extracorporeal circulation (ECC) is often induced and/or aggravated by thrombocytopenia due to platelet-trapping in hollow fiber membrane oxygenators (HFMO). Nitric oxide (NO) has platelet anti-aggregating and dis-aggregating properties. In a paired system we tested whether gaseous NO, added to the gas compartment of one of two parallel running heparin-bonded HFMO attenuated platelet-trapping. Platelet consumption was markedly reduced in the NO-treated HFMO. These data strongly indicate that the application of gaseous NO could prove a new therapeutical approach to reduce bleeding during ECC, serving as a new way of preventing platelet loss, thus reducing the need for high systemic heparinization.
2018 ◽
Vol 10
(7)
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pp. 1989-2000
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2002 ◽
Vol 19
(6)
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pp. 575-583
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2008 ◽
Vol 36
(6)
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pp. 992-1003
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Keyword(s):
Keyword(s):
2020 ◽
Vol 20
(1)
◽
pp. 78-85
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Keyword(s):
1989 ◽
Vol 35
(3)
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pp. 667-670
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Keyword(s):
1998 ◽
Vol 147
(1)
◽
pp. 87-93
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Keyword(s):
Keyword(s):