Fatal accidental lipid overdose with intravenous composite lipid emulsion in a premature newborn: a case report

Background Tenfold or more overdose of a drug or preparation is a dreadful adverse event in neonatology, often due to an error in programming the infusion pump flow rate. Lipid overdose is exceptional in this context and has never been reported during the administration of a composite intravenous lipid emulsion (ILE). Case presentation Twenty-four hours after birth, a 30 weeks’ gestation infant with a birthweight of 930 g inadvertently received 28 ml of a composite ILE over 4 h. The ILE contained 50% medium-chain triglycerides and 50% soybean oil, corresponding to 6 g/kg of lipids (25 mg/kg/min). The patient developed acute respiratory distress with echocardiographic markers of pulmonary hypertension and was treated with inhaled nitric oxide and high-frequency oscillatory ventilation. Serum triglyceride level peaked at 51.4 g/L, 17 h after the lipid overload. Triple-volume exchange transfusion was performed twice, decreasing the triglyceride concentration to < 10 g/L. The infant’s condition remained critical, with persistent bleeding and shock despite supportive treatment and peritoneal dialysis. Death occurred 69 h after the overdose in a context of refractory lactic acidosis. Conclusions Massive ILE overdose is life-threatening in the early neonatal period, particularly in premature and hypotrophic infants. This case highlights the vigilance required when ILEs are administered separately from other parenteral intakes. Exchange transfusion should be considered at the first signs of clinical or biological worsening to avoid progression to multiple organ failure.

A 2D model for the study of equilibrium glide paths of UiS Subsea Freight-Glider

A planar mathematical model for the analysis of equilibrium glide paths of the UiS subsea freight-glider (USFG) is presented. The model is developed using Simscape Multibody in MATLAB/Simulink to study the ever-changing dynamics of the glider. Motion along the heave and pitch direction is regulated by two separate PID controllers. Controllers are tuned for the optimal bandwidth and phase margin to provide the system with ideal gains which satisfy the system requirements. A wide-ranging sensitivity investigation is carried out on the USFG by changing the two key variables, pump flow rate and ballast fraction. The results reflect the advantages of using higher flow capacity and ballast fraction, which should be preferred according to the application, provided if there are no space and weight restrictions. Finally, different glide paths were simulated to observe that, controller gains obtained from the linear model can be improved to acquire better performance in terms of robustness and stability of the system.

A New Analytical Approach To Calculate a Slippage inside a Progressing Cavity Pump with a Metallic Stator Using a Middle Streamline and a Structural Periodicity

Summary Simplified and 3D models have been studied to predict the performance of progressing cavity pumps (PCPs). Simplified models were mainly made for metallic stator PCP performance. Their purpose was to represent the relationship between pump flow rate and differential pressure. Previous studies proposed to solve the system of mass conservation equations. In these studies, the geometry of the gap area was not clearly represented by neglecting the curvatures of stator and rotor. In addition, only frictional loss was considered, but local loss by gradual contraction or expansion of the gap area was not considered. In this study, we present a new analytical approach considering curvature and local loss. The depth of the gap area and local loss could be calculated analytically by a middle streamline and a curvature. On the basis of periodicity of distribution of cavities, simplified calculation for a slippage was possible without a system of mass conservation equations. Therefore, this model represents clearer geometry and a more simplified approach. The results show that this model shortens the calculating time and facilitates programing; in addition, the model validation is good in matching with experimental data.

Experimental Investigation of a Double-Acting Vane Pump with Integrated Electric Drive

The article presents an innovative design solution of a balanced vane pump integrated with an electric motor that has been developed by the authors. The designed and constructed bench, which enables testing of the system: power supply, converter, ntegrated motor—pump assembly and hydraulic load at different motor speeds and different pressures in the hydraulic system, is described. The electromagnetic and hydraulic processes in the motor-pump unit are investigated, and new, previously unpublished, results of experimental studies at steady and dynamic states are presented. The results of the study showed good dynamics of the integrated motor-pump assembly and proved its suitability to control the pump flow rate, and thus, the speed of the hydraulic cylinder or the speed of the hydraulic motor.

Fabrication of PVA/Carbon-Based Nanofibers Using Electrospinning

Nanofibers are widely used in various fields, including water filtration. In the development of nanofibers as water filtration, a mixture of carbon in a polymer solution is often used. Nanofibers can be made by several methods such as multicomponent fiber spinning techniques, melt blowing, electrospinning. Electrospinning is currently a simple development method but can produce nanofibers with a small fiber diameter, it is easy to develop and many parameters can be controlled. Parameters that affect the results of the nanofibers that are formed include flow rate or syringe pump flow rate and high voltage dc high voltage. Various types of nanofibers can be produced from various types of polymers, both natural polymers and synthetic polymers. Generally, because they have properties and characteristics such as high surface area, small pore size, and the possibility to be developed in various applications. Therefore, this chapter discusses the electrospinning of carbon nanofibers using PVA polymer.

Comparative study of drip irrigation systems using indoor amorphous photovoltaic panels

Solar energy is a clean and renewable energy production option and can be applied to pumping water. Pumping water with photovoltaic solar energy is one of the technologies that has stood out in the country. In this context, the work aimed to evaluate the different methods of a drip irrigation system as a function of the use of an indoor amorphous photovoltaic pumping system, without electrical energy storage. The study was installed at the State University of Western Paraná. Voltage and current data were generated by the photovoltaic panels; solar irradiation was measured by the pyranometer device; the water pump flow rate was determined using the flow meter and in-line drip tube types. Irrigation performance was determined by the water distribution uniformity coefficients (CUD) and Christiansen’s uniformity coefficient (CUC). Tests were performed on open and partially cloudy days. The experiment totaled 40 sampled data, half being collected on sunny days and the other half on partially cloudy days, at 9:45 am; 11:00 am; 1:30 pm and 3:00 pm. The methodology had the greatest influence on the CUD value. For the CUC parameter, the values were approximately 89% for the studied methods. Values remained under control for the Shewhart graph, but with the process capacity index affected.

Non-intrusive data-driven ROM framework for hemodynamics problems

Reduced order modeling (ROM) techniques are numerical methods that approximate the solution of parametric partial differential equation (PED) by properly combining the high-fidelity solutions of the problem obtained for several configurations, i.e. for several properly chosen values of the physical/geometrical parameters characterizing the problem. By starting from a database of high-fidelity solutions related to a certain values of the parameters, we apply the proper orthogonal decomposition with interpolation (PODI) and then reconstruct the variables of interest for new values of the parameters, i.e. different values from the ones included in the database. Furthermore, we present a preliminary web application through which one can run the ROM with a very user-friendly approach, without the need of having expertise in the numerical analysis and scientific computing field. The case study we have chosen to test the efficiency of our algorithm is represented by the aortic blood flow pattern in presence of a left ventricular (LVAD) assist device when varying the pump flow rate.

Impact of Pumping Rate on Contaminant Transport in Groundwater—A Numerical Study

Public supply wells are commonly considered one of the most significant sources of freshwater on Earth. Therefore, potential well water contamination can conceivably be regarded as a crucial issue that is closely correlated with both environmental protection and water demand. In the present study, a three-dimensional numerical model is developed to simulate unsteady and spatially varying groundwater flow, along with contaminant migration. Besides, the proposed model is capable of investigating well water quality by the change of the wells’ pumping rates. The developed model uses a finite-volume time splitting numerical technique to solve governing groundwater flow and soluble contaminant transport equations. Comparison of the numerical simulation results with analytical solutions, as well as experimental and field data, clearly demonstrates the satisfactory performance of the present model. The fundamental aim of the study is to evaluate the effect of pumping rate and its variations on pollution migration through saturated porous media. To meet this purpose, contaminant concentrations and contaminants’ travel time were studied under different pump flow rate conditions. The modeling results revealed that choosing an optimum range for the pumping rate increases contaminant travel time and reduces aquifer vulnerability.

Dynamic simulation of inner flow in a photovoltaic pump based on Simulink and CFD

To study the internal flow characteristics of the photovoltaic pump under the transient change of the solar radiation, the simulation algorithm of the photovoltaic pump system was established by MATLAB/Simulink and CFD for the first time and the results were validated by the test. Firstly, the change rule of pump flow rate and rotation speed under transient solar radiation was obtained by Simulink. Then the results of the change rule were transformed into the boundary condition of CFD by CEL function and the transient flow field in the photovoltaic pump was obtained. The internal flow characteristics and pressure pulsation in the pump were analyzed when the solar radiation increases or decreases transiently. The results demonstrate that the numerical calculation can provide accurate prediction for the characteristics of internal flow in the pump. The numerical results are closed to experimental results, the minimum error of pressure is 0.93% and the maximum error is 1.78%. When the solar radiation increases transiently, the low pressure area at the impeller inlet gets larger obviously and the jet-wake at the impeller outlet becomes more obvious. The pressure pulsation in impeller gradually increases and becomes stable after 0.6 s. The pressure from the impeller outlet to guide vane outlet is stable at 123 kPa. When the solar radiation decreases transiently, the pressure in the impeller takes 1.6 s to be stable. Larger pressure pulsation occurs from the impeller outlet to the guide vane inlet and the maximum differential pressure is 10 kPa. Compared with the transient increase of solar radiation, the pressure in the impeller takes more 0.2 s to stabilize when the solar radiation transient decreases. Meanwhile, the results in this paper can provide references for other transient characteristics research.

Influence of cardiopulmonary bypass set-up and management on clinical outcomes after minimally invasive aortic valve surgery

Introduction: Minimally invasive aortic valve replacement (MIAVR) requires changes in cannulation strategy and cardiopulmonary bypass (CPB) management when compared to the conventional approach (CAVR). We aimed at evaluating if these differences could influence perfusion-related quality parameters and impair postoperative outcomes. Methods: Overall, 339 consecutive patients underwent MIAVR or CAVR between 2014 and 2020 and were analyzed retrospectively. To account for baseline differences, a propensity-matching analysis was performed, obtaining two groups of 97 patients each. Results: MIAVR group had longer CPB time [107 (95–120) vs 95 (86–105) min, p = .003] than CAVR group. Of note, average pump flow rate index [2.4 (2.2–2.5) vs 2.7 (2.4–2.8) l/min/m2, p = .004] was lower in the MIAVR group. Mean arterial pressure was 73 = 9 mmHg vs 62 = 11 mmHg for the MIAVR and CAVR group, respectively (p < .001). Cell-salvaged blood was most commonly used in the MIAVR group (25.8% vs 11.3%, p = .02). Finally, CPB temperature was 32.8°C (32.1–34.8) for MIAVR group vs 34.9°C (33.2–36.1) for the CAVR group (p = .02). Postoperative complications were similar between groups. Conclusions: In conclusion, despite differences in CPB parameters in patients undergoing CAVR and MIAVR, the incidences of adverse outcomes were similar. However, compared to CAVR, MIAVR was associated with shorter durations of mechanical ventilation and hospital stay as well as less transfusion of blood products.