Pumping O2 with no N2: An Overview of Hollow Fiber Membrane Oxygenators with Integrated Arterial Filters

2020 ◽  
Vol 20 (1) ◽  
pp. 78-85 ◽  
Author(s):  
Anxin Liu ◽  
Zhiquan Sun ◽  
Qier Liu ◽  
Ning Zhu ◽  
Shigang Wang
Keyword(s):  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Experimental Studies ◽  
Circulation System ◽  
Fiber Membrane ◽  
Priming Volume ◽  
Membrane Oxygenators ◽  
Set Up

The advancement of cardiac surgery benefits from the continual technological progress of cardiopulmonary bypass (CPB). Every improvement in the CPB technology requires further clinical and laboratory tests to prove its safety and effectiveness before it can be widely used in clinical practice. In order to reduce the priming volume and eliminate a separate arterial filter in the CPB circuit, several manufacturers developed novel hollow-fiber membrane oxygenators with integrated arterial filters (IAF). Clinical and experimental studies demonstrated that an oxygenator with IAF could reduce total priming volume, blood donor exposure and gaseous microemboli delivery to the patient. It can be easily set up and managed, simplifying the CPB circuit without sacrificing safety. An oxygenator with IAF is expected to be more beneficial to the patients with low body weight and when using a minimized extracorporeal circulation system. The aim of this review manuscript was to discuss briefly the concept of integration, the current oxygenators with IAF, and the in-vitro / in-vivo performance of the oxygenators with IAF.

scholarly journals AN69 Hollow Fiber Membrane will Reduce but Not Abolish the Risk of Transmission of Porcine Endogenous Retroviruses

2005 ◽  
Vol 14 (10) ◽  
pp. 749-756 ◽  
Author(s):  
Oleg Pakhomov ◽  
Lionel Martignat ◽  
Jiri Honiger ◽  
Béatrice Clémenceau ◽  
Pierre Säi ◽  
...  
Keyword(s):  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Hollow Fibre ◽  
Human Cells ◽  
Endogenous Retroviruses ◽  
Fiber Membrane ◽  
The Real ◽  
Porcine Endogenous Retrovirus

As the risk of porcine endogenous retrovirus (PERV) infection is a major obstacle to the xenotransplantation of porcine tissue, we investigated whether an AN69 hollow fibre membrane, used for islets of Langerhans transplantation, could prevent the transfer of PERVs and thus reduce the risk of PERV infection. PK15 cells were used as a PERV source. A specific and highly sensitive RCR was used for detection of a PERV provirus DNA (gag region) and a porcine mtDNA. Human U293 cells were incubated in vitro with encapsulated PK15 cells, concentrated encapsulated PK15 supernatant, or concentrated PK15 supernatant as a control. CD1 mice were implanted in vivo with encapsulated PK15 cells or injected with PK15 supernatant. We found no infection in human cells incubated with either encapsulated PK15 supernatant or in 10 out of 11 samples after coincubation with encapsulated PK15 cells. Infection of human cells was, however, detected in 1 out of 11 samples after coincubation with encapsulated PK15 cells. The presence of PERV provirus DNA and porcine mtDNA was detected in all the investigated tissues of the mice injected with PK15 supernatant and in various tissues of the mice implanted with encapsulated PK15 cells. Four weeks after the last injection of PK15 supernatant or a fiber explantation, no mouse showed any presence of PERV provirus DNA or porcine mtDNA. Our results demonstrate that AN69 hollow fiber membrane will reduce but not abolish the risk of PERV infection. Because the real risk of PERV infection still remains unknown, it is necessary to investigate further the real protection that could be provided by hollow fibers to ensure the safety of clinical xenotransplantation.

Hollow fiber membrane applied for Sasirangan wastewater desalination integrated with photocatalysis and pervaporation set-up

2021 ◽  
Author(s):  
Isnasyauqiah ◽  
Muthia Elma ◽  
Eggy A. Pradana ◽  
Muhammad D. Ul-haq ◽  
Erdina L.A. Rampun ◽  
...  
Keyword(s):  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Fiber Membrane ◽  
Set Up

Reduction of Platelet Trapping in Membrane Oxygenators by Transmembraneous Application of Gaseous Nitric Oxide

1996 ◽  
Vol 19 (5) ◽  
pp. 291-293 ◽  
Author(s):  
D. Keh ◽  
M. Gerlach ◽  
I. Kürer ◽  
K.J. Falke ◽  
H. Gerlach
Keyword(s):  
Nitric Oxide ◽  
Extracorporeal Circulation ◽  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Fiber Membrane ◽  
Systemic Heparinization ◽  
Membrane Oxygenators

Bleeding during extracorporeal circulation (ECC) is often induced and/or aggravated by thrombocytopenia due to platelet-trapping in hollow fiber membrane oxygenators (HFMO). Nitric oxide (NO) has platelet anti-aggregating and dis-aggregating properties. In a paired system we tested whether gaseous NO, added to the gas compartment of one of two parallel running heparin-bonded HFMO attenuated platelet-trapping. Platelet consumption was markedly reduced in the NO-treated HFMO. These data strongly indicate that the application of gaseous NO could prove a new therapeutical approach to reduce bleeding during ECC, serving as a new way of preventing platelet loss, thus reducing the need for high systemic heparinization.

scholarly journals Use of a Mathematical Model to Predict Oxygen Transfer Rates in Hollow Fiber Membrane Oxygenators

ASAIO Journal ◽  
1994 ◽  
Vol 40 (4) ◽  
pp. 990-996 ◽  
Author(s):  
Steven N. Vaslef ◽  
Lyle F. Mockros ◽  
Robert W. Anderson ◽  
Ronald J. Leonard
Keyword(s):  
Mathematical Model ◽  
Hollow Fiber ◽  
Oxygen Transfer ◽  
Hollow Fiber Membrane ◽  
Fiber Membrane ◽  
Transfer Rates ◽  
Membrane Oxygenators

Comparison of hollow-fiber membrane oxygenators with different perfusion modes during normothermic and hypothermic CPB in a simulated neonatal model

Perfusion ◽  
2006 ◽  
Vol 21 (6) ◽  
pp. 381-390 ◽  
Author(s):  
Akif Ündar ◽  
Bingyang Ji ◽  
Branka Lukic ◽  
Conrad M Zapanta ◽  
Allen R Kunselman ◽  
...  
Keyword(s):  
Hollow Fiber ◽  
Hollow Fiber Membrane ◽  
Energy Levels ◽  
Repeated Measurements ◽  
Fiber Membrane ◽  
Pressure Drops ◽  
Pump Flow ◽  
Pump Flow Rate ◽  
Membrane Oxygenators ◽  
Pulsatile Perfusion

Purpose: The objectives of this investigation were (1) to compare two hollow-fiber membrane oxygenators (Capiox Baby RX versus Lilliput 1-D901) in terms of pressure drops and surplus hemodynamic energy (SHE) during normothermic and hypothermic cardiopulmonary bypass (CPB) in a simulated neonatal model; and (2) to evaluate pulsatile and non-pulsatile perfusion modes for each oxygenator in terms of SHE levels. Methods: In a simulated patient, CPB was initiated at a constant pump flow rate of 500 mL/min. The circuit was primed with fresh bovine blood. After 5 min of normothermic CPB, the pseudo-patient was cooled down to 25°C for 10 min followed by 30 min of hypothermic CPB. The pseudo-patient then underwent 10 min of rewarming and 5 min of normothermic CPB. At each experimental site (pre- and post-oxygenator and pre-aortic cannula), SHE was calculated using the following formula {SHE (ergs/cm3) = 1332 [((ffpdt)/(ffdt))-mean arterial pressure]} (f = pump flow and p = pressure). A linear mixed-effects model that accounts for the correlation among repeated measurements was fit to the data to assess differences in SHE between oxygenators, pumps, and sites. Tukey’s multiple comparison procedure was used to adjust p-values for post-hoc pairwise comparisons. Results: The pressure drops in the Capiox group compared to the Lilliput group were significantly lower during hypothermic non-pulsatile (21.3∓0.5 versus 50.7∓0.9 mmHg, p B < 0.001) and pulsatile (22∓0.0 versus 53.3∓0.5 mmHg, p < 0.001) perfusion, respectively. Surplus hemodynamic energy levels were significantly higher in the pulsatile group compared to the non-pulsatile group, with Capiox (1655∓92 versus 10 008∓1370 ergs/cm3, p < 0.001) or Lilliput (1506∓112 versus 7531∓483 ergs/cm3, p < 0.001) oxygenators. During normothermic CPB, both oxygenators had patterns similar to those observed under hypothermic conditions. Conclusions: The Capiox oxygenator had a significantly lower pressure drop in both pulsatile and non-pulsatile perfusion modes. For each oxygenator, the SHE levels were significantly higher in the pulsatile mode.

Sign in / Sign up

Export Citation Format

Share Document