Endocavitary Prophylaxis of Superficial Urothelial Bladder Tumours: New Compounds

2009 ◽  
Vol 76 (1) ◽  
pp. 1-9
Author(s):  
R. Bartoletti ◽  
T. Cai

1981 ◽  
Vol 53 (4) ◽  
pp. 324-329 ◽  
Author(s):  
L. HEMMINGSEN ◽  
F. RASMUSSEN ◽  
P. SKAARUP ◽  
H. WOLF


2019 ◽  
Vol 56 (3) ◽  
pp. 254 ◽  
Author(s):  
Avinash Gupta ◽  
Sukhpreet Kaur ◽  
HanniV Gulwani


2015 ◽  
Vol 63 (6) ◽  
pp. 628-634 ◽  
Author(s):  
S. Roperto ◽  
V. Russo ◽  
L. Leonardi ◽  
M. Martano ◽  
F. Corrado ◽  
...  


2017 ◽  
Vol 474 (8) ◽  
pp. 1333-1346 ◽  
Author(s):  
Ahmad Fahim Ismail ◽  
Sevil Oskay Halacli ◽  
Nouf Babteen ◽  
Mario De Piano ◽  
Tracey A. Martin ◽  
...  

Urothelial bladder cancer is a major cause of morbidity and mortality worldwide, causing an estimated 150 000 deaths per year. Whilst non-muscle-invasive bladder tumours can be effectively treated, with high survival rates, many tumours recur, and some will progress to muscle-invasive disease with a much poorer long-term prognosis. Thus, there is a pressing need to understand the molecular transitions occurring within the progression of bladder cancer to an invasive disease. Tumour invasion is often associated with a down-regulation of E-cadherin expression concomitant with a suppression of cell:cell junctions, and decreased levels of E-cadherin expression have been reported in higher grade urothelial bladder tumours. We find that expression of E-cadherin in a panel of bladder cancer cell lines correlated with the presence of cell:cell junctions and the level of PAK5 expression. Interestingly, exogenous PAK5 has recently been described to be associated with cell:cell junctions and we now find that endogenous PAK5 is localised to cell junctions and interacts with an E-cadherin complex. Moreover, depletion of PAK5 expression significantly reduced junctional integrity. These data suggest a role for PAK5 in maintaining junctional stability and we find that, in both our own patient samples and a commercially available dataset, PAK5mRNA levels are reduced in human bladder cancer compared with normal controls. Taken together, the present study proposes that PAK5 expression levels could be used as a novel prognostic marker for bladder cancer progression.



2003 ◽  
Vol 14 (9) ◽  
pp. 1419-1424 ◽  
Author(s):  
L. Santos ◽  
C. Costa ◽  
S. Pereira ◽  
M. Koch ◽  
T. Amaro ◽  
...  


2006 ◽  
Vol 5 (2) ◽  
pp. 36
Author(s):  
F. Descotes ◽  
M. Decaussin ◽  
C. Grenot ◽  
J.L. Campos-Fernandes ◽  
J. Andre ◽  
...  


2007 ◽  
Vol 52 (3) ◽  
pp. 760-768 ◽  
Author(s):  
Johanna M.M. van Oers ◽  
Peter J. Wild ◽  
Maximilian Burger ◽  
Stefan Denzinger ◽  
Robert Stoehr ◽  
...  


1985 ◽  
Vol 28 (1) ◽  
pp. 59-63
Author(s):  
B. Blume ◽  
F. Theuring ◽  
P. Blume ◽  
A. Richter ◽  
F. Rabe


2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Matthew A. Llewellyn ◽  
Naheema S. Gordon ◽  
Ben Abbotts ◽  
Nicholas D. James ◽  
Maurice P. Zeegers ◽  
...  


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