Bovine Papillomavirus Type 13 Expression in the Urothelial Bladder Tumours of Cattle

2015 ◽  
Vol 63 (6) ◽  
pp. 628-634 ◽  
Author(s):  
S. Roperto ◽  
V. Russo ◽  
L. Leonardi ◽  
M. Martano ◽  
F. Corrado ◽  
...  
Keyword(s):  
Bovine Papillomavirus ◽  
Urothelial Bladder ◽  
Bladder Tumours

Urinary Protein Profiles in Patients with Urothelial Bladder Tumours

1981 ◽  
Vol 53 (4) ◽  
pp. 324-329 ◽  
Author(s):  
L. HEMMINGSEN ◽  
F. RASMUSSEN ◽  
P. SKAARUP ◽  
H. WOLF
Keyword(s):  
Urinary Protein ◽  
Protein Profiles ◽  
Urothelial Bladder ◽  
Bladder Tumours

Sigma-2 Receptor Expression in Bovine Papillomavirus-Associated Urinary Bladder Tumours

2010 ◽  
Vol 142 (1) ◽  
pp. 19-26 ◽  
Author(s):  
S. Roperto ◽  
N.A. Colabufo ◽  
C. Inglese ◽  
C. Urraro ◽  
R. Brun ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Receptor Expression ◽  
Bovine Papillomavirus ◽  
Bladder Tumours

Association of bovine papillomavirus type-2 and urinary bladder tumours in cattle from Romania

2008 ◽  
Vol 85 (1) ◽  
pp. 145-148 ◽  
Author(s):  
L.G.F. Balcos ◽  
G. Borzacchiello ◽  
V. Russo ◽  
O. Popescu ◽  
S. Roperto ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Bovine Papillomavirus ◽  
Bladder Tumours

Endocavitary Prophylaxis of Superficial Urothelial Bladder Tumours: New Compounds

2009 ◽  
Vol 76 (1) ◽  
pp. 1-9
Author(s):  
R. Bartoletti ◽  
T. Cai
Keyword(s):  
Urothelial Bladder ◽  
New Compounds ◽  
Bladder Tumours

scholarly journals Detection of bovine papillomavirus type 2 in the peripheral blood of cattle with urinary bladder tumours: possible biological role

2008 ◽  
Vol 89 (12) ◽  
pp. 3027-3033 ◽  
Author(s):  
Sante Roperto ◽  
Roberto Brun ◽  
Francesca Paolini ◽  
Chiara Urraro ◽  
Valeria Russo ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Peripheral Blood ◽  
Bladder Tumour ◽  
Biological Role ◽  
Bovine Papillomavirus ◽  
Simultaneous Presence ◽  
Adult Cattle ◽  
Blood Samples ◽  
Bladder Tumours

Bovine papillomavirus type 2 (BPV-2) infection has been associated with urinary bladder tumours in adult cattle grazing on bracken fern-infested land. In this study, we investigated the simultaneous presence of BPV-2 in whole blood and urinary bladder tumours of adult cattle in an attempt to better understand the biological role of circulating BPV-2. Peripheral blood samples were collected from 78 cattle clinically suffering from a severe chronic enzootic haematuria. Circulating BPV-2 DNA was detected in 61 of them and in two blood samples from healthy cows. Fifty of the affected animals were slaughtered at public slaughterhouses and neoplastic proliferations in the urinary bladder were detected in all of them. BPV-2 DNA was amplified and sequenced in 78 % of urinary bladder tumour samples and in 38.9 % of normal samples as a control. Circulating episomal BPV-2 DNA was detected in 78.2 % of the blood samples. Simultaneous presence of BPV-2 DNA in neoplastic bladder and blood samples was detected in 37 animals. Specific viral E5 mRNA and E5 oncoprotein were also detected in blood by RT-PCR and Western blot/immunocytochemistry, respectively. It is likely that BPV-2 can persist and be maintained in an active status in the bloodstream, in particular in the lymphocytes, as a reservoir of viral infection that, in the presence of co-carcinogens, may cause the development of urinary bladder tumours.

A clinicopathological and immunohistochemical study of non-urothelial bladder tumours

2019 ◽  
Vol 56 (3) ◽  
pp. 254 ◽  
Author(s):  
Avinash Gupta ◽  
Sukhpreet Kaur ◽  
HanniV Gulwani
Keyword(s):  
Immunohistochemical Study ◽  
Urothelial Bladder ◽  
Bladder Tumours

scholarly journals PAK5 mediates cell: cell adhesion integrity via interaction with E-cadherin in bladder cancer cells

2017 ◽  
Vol 474 (8) ◽  
pp. 1333-1346 ◽  
Author(s):  
Ahmad Fahim Ismail ◽  
Sevil Oskay Halacli ◽  
Nouf Babteen ◽  
Mario De Piano ◽  
Tracey A. Martin ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Progression ◽  
Survival Rates ◽  
Invasive Disease ◽  
Cell Junctions ◽  
High Survival ◽  
Urothelial Bladder ◽  
Muscle Invasive ◽  
Bladder Tumours ◽  
E Cadherin

Urothelial bladder cancer is a major cause of morbidity and mortality worldwide, causing an estimated 150 000 deaths per year. Whilst non-muscle-invasive bladder tumours can be effectively treated, with high survival rates, many tumours recur, and some will progress to muscle-invasive disease with a much poorer long-term prognosis. Thus, there is a pressing need to understand the molecular transitions occurring within the progression of bladder cancer to an invasive disease. Tumour invasion is often associated with a down-regulation of E-cadherin expression concomitant with a suppression of cell:cell junctions, and decreased levels of E-cadherin expression have been reported in higher grade urothelial bladder tumours. We find that expression of E-cadherin in a panel of bladder cancer cell lines correlated with the presence of cell:cell junctions and the level of PAK5 expression. Interestingly, exogenous PAK5 has recently been described to be associated with cell:cell junctions and we now find that endogenous PAK5 is localised to cell junctions and interacts with an E-cadherin complex. Moreover, depletion of PAK5 expression significantly reduced junctional integrity. These data suggest a role for PAK5 in maintaining junctional stability and we find that, in both our own patient samples and a commercially available dataset, PAK5mRNA levels are reduced in human bladder cancer compared with normal controls. Taken together, the present study proposes that PAK5 expression levels could be used as a novel prognostic marker for bladder cancer progression.

scholarly journals Association of Bovine Papillomavirus Type 2 (BPV-2) and Urinary Bladder Tumours in Cattle from the Azores Archipelago

2009 ◽  
Vol 141 (4) ◽  
pp. 305
Author(s):  
A.R. Resendes ◽  
S. Roperto ◽  
U. Chiara ◽  
F. Trapani ◽  
F. Roperto ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Bovine Papillomavirus ◽  
Azores Archipelago ◽  
Bladder Tumours

Evidence of Bovine Papillomavirus Type 2 in the Placenta of Cows with Urinary Bladder Tumours

2012 ◽  
Vol 146 (1) ◽  
pp. 58
Author(s):  
S. Roperto ◽  
R. Lucà ◽  
C. Urraro ◽  
I. Esposito ◽  
M. Riccardi ◽  
...  
Keyword(s):  
Urinary Bladder ◽  
Bovine Papillomavirus ◽  
Bladder Tumours

scholarly journals Neovascularisation is a prognostic factor of early recurrence in T1/G2 urothelial bladder tumours

2003 ◽  
Vol 14 (9) ◽  
pp. 1419-1424 ◽  
Author(s):  
L. Santos ◽  
C. Costa ◽  
S. Pereira ◽  
M. Koch ◽  
T. Amaro ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Early Recurrence ◽  
Urothelial Bladder ◽  
Bladder Tumours
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