HLA-DRβ2 and IgM Rheumatoid Factor (RF) Positive Rheumatoid Arthritis (RA)

1988 ◽  
Vol 1 (2) ◽  
pp. 119-122
Author(s):  
G. Haberhauer ◽  
P. Peichl
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Control Subject ◽  
Disease Susceptibility ◽  
Healthy Control Subject ◽  
Chain Gene ◽  
Igm Rheumatoid Factor ◽  
Healthy Control

48 patients suffering from classic erosive RA with conditions persisting for more than 6 years were examined together with 69 healthy control subject with regard to associations to supertypic HLA-D specificities. We found a significant increase of HLA-DRw53 in patients with RF positive RA (22/31 pat. = 71%,Chi2 = 13.2, p<0.01). Our results confirm the hypothesis that the HLA-DRβ2 chain gene is closer related to the disease susceptibility of seropositive RA than the DRβ1 chain gene (DR4).

scholarly journals A spontaneous rheumatoid arthritis-like disease in MRL/l mice.

1982 ◽  
Vol 155 (6) ◽  
pp. 1690-1701 ◽  
Author(s):  
L Hang ◽  
A N Theofilopoulos ◽  
F J Dixon
Keyword(s):  
Rheumatoid Arthritis ◽  
Rheumatoid Factor ◽  
Joint Inflammation ◽  
Close Correlation ◽  
Human Rheumatoid Arthritis ◽  
Igm Rheumatoid Factor ◽  
Joint Pathology ◽  
Old Females

MRL/l mice spontaneously develop an arthritis very similar in many respects to human rheumatoid arthritis. A detailed morphologic and serologic analysis of this disease revealed the following: (a) a 75% incidence of synovial and periarticular inflammation, very similar to human rheumatoid arthritis, in 5-6 mo-old females, (b) close associations between presence of joint inflammation and subsynovial and/or periarticular vasculitis, and (c) a close correlation between presence of circulating IgM rheumatoid factor (RF) and demonstrable synovial and/or joint pathology, i.e., 95% of mice with significant levels of IgMRF had synovitis and/or arthritis.

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