Silicone Gel Implants Associated with Autoimmune/Connective Tissue Disease

1992 ◽  
Vol 9 (4) ◽  
pp. 337-345 ◽  
Author(s):  
Melvin A. Shiffman
Keyword(s):  
Autoimmune Disease ◽  
Connective Tissue ◽  
Autoimmune Diseases ◽  
Connective Tissue Disease ◽  
Occurrence Rate ◽  
Silicone Implants ◽  
Age Group ◽  
Effect Relationship ◽  
Silicone Gel ◽  
Causative Relationship

The association of silicone implants with autoimmune disease is comprehensively reviewed and four new cases presented. In some instances of reported cases there appears to be a cause-and-effect relationship between silicone gel implants and the onset of autoimmune diseases, although in most cases the disease appears to be more likely the expected occurrence rate in females of this age group. Basic criteria for establishing a possible causative relationship are presented.

scholarly journals AB0313 THE CLINICAL CHARACTERISTICS OF PATIENTS WITH IMMUNE-ASSOCIATED ADVERSE PREGNANCY

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 1182.1-1182
Author(s):  
W. Su ◽  
Y. Zhuang ◽  
J. Zhu
Keyword(s):  
Autoimmune Disease ◽  
Connective Tissue ◽  
Autoimmune Diseases ◽  
Connective Tissue Disease ◽  
Lupus Erythematosus ◽  
Clinical Characteristics ◽  
Anticardiolipin Antibody ◽  
Antiphospholipid Antibody ◽  
Positive Rate ◽  
Adverse Pregnancy

Background:Immune-associated adverse pregnancy is the adverse pregnancy outcomes induced by autoimmune factors or autoimmune diseases, including infertility, recurrent spontaneous abortion, failed assisted reproduction, fetal growing restriction. It is helpful to explore the mechanism and improve the management by analyzing the clinical characteristics of patients with immune-associated adverse pregnancy.Objectives:To find the risk factors of Immune-associated adverse pregnancy by analyzing the clinical characteristics of patients with immune-associated adverse pregnancy.Methods:The patients involved in this study were from the multi-department clinic of immune-associated adverse pregnancy, during April 2019 and August 2020. They were diagnosed with autoimmune diseases according to relative classification standards or with autoimmune abnormality. Patients with adverse pregnancy due to anatomic, endocrine, infectious and chromosomal factors were excluded.Results:A total of 107 patients were included. The average age was 29.3 years old. The number of total adverse pregnancy was 115 and the average was 1.07. For the diagnosis, 22 (22.4%) were autoimmune abnormality (with autoantibody but cannot be classified to any autoimmune disease), 30 (28.0%) were antiphospholipid syndrome (APS), 17 (15.9%) were systemic lupus erythematosus (SLE), 13 (12.1%) were mixed connective tissue disease (MCTD), 8 (7.5%) were undifferentiated connective tissue disease, 5 (4.7%) were Sjogren syndrome (SS), other autoimmune disease account for 10 (9.4%). For the antibodies, the positive rate of ANA was 44.8% (48/107), anti-SSA 36.4% (39/107) anti-RNP 15.0% (16/107), anti-dsDNA8.4% (9/107), anti-Sm 9.3% (10/107), anticardiolipin antibody 17.8% (19/107), anti-B2GP1 24.3% (26/107), LA 8.4% (9/107), non-criteria antiphospholipid antibody 3.7% (4/107).Conclusion:Our data showed that autoimmune abnormality, SLE, APS, MTCD and SS impacted immune-associated adverse pregnancy the most. The most crucial antibodies were ANA, anti-SSA, anti-RNP, anti-dsDNA and antiphospholipid antibodies.Disclosure of Interests:None declared

Silicone Implants and Connective Tissue Disease: 5 Cases

2007 ◽  
Vol 6 (1) ◽  
pp. 30-34
Author(s):  
Ayelet Rishpon ◽  
Yonit Wohl ◽  
Yoav Barnea ◽  
Michael Ehrenfeld ◽  
Jerry Weiss ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Silicone Implants

Silicon Analysis of Breast and Capsular Tissue from Patients with Saline or Silicone Gel Breast Implants: II. Correlation with Connective-Tissue Disease

1998 ◽  
Vol 101 (7) ◽  
pp. 1836-1841 ◽  
Author(s):  
Jeffrey Weinzweig ◽  
Paul L. Schnur ◽  
Joseph P. McConnell ◽  
John B. Harris ◽  
Paul M. Petty ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Breast Implants ◽  
Silicone Gel

scholarly journals Serum proteins and paraproteins in women with silicone implants and connective tissue disease: a case–control study

2007 ◽  
Vol 9 (5) ◽  
pp. R95 ◽  
Author(s):  
Gyorgy Csako ◽  
Rene Costello ◽  
Ejaz A Shamim ◽  
Terrance P O'Hanlon ◽  
Anthony Tran ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Case Control Study ◽  
Serum Proteins ◽  
Case Control ◽  
Silicone Implants ◽  
Control Study

scholarly journals Tetramers reveal IL-17–secreting CD4+ T cells that are specific for U1-70 in lupus and mixed connective tissue disease

2015 ◽  
Vol 112 (10) ◽  
pp. 3044-3049 ◽  
Author(s):  
Nicole H. Kattah ◽  
Evan W. Newell ◽  
Justin Ansel Jarrell ◽  
Alvina D. Chu ◽  
Jianming Xie ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Autoimmune Disease ◽  
Connective Tissue ◽  
Connective Tissue Disease ◽  
Mhc Class Ii ◽  
Lupus Erythematosus ◽  
Mixed Connective Tissue Disease ◽  
Cell Populations ◽  
Autoantibody Production

Antigen-specific CD4+ T cells are implicated in the autoimmune disease systemic lupus erythematosus (SLE), but little is known about the peptide antigens that they recognize and their precise function in disease. We generated a series of MHC class II tetramers of I-Ek–containing peptides from the spliceosomal protein U1-70 that specifically stain distinct CD4+ T-cell populations in MRL/lpr mice. The T-cell populations recognize an epitope differing only by the presence or absence of a single phosphate residue at position serine140. The frequency of CD4+ T cells specific for U1-70(131-150):I-Ek (without phosphorylation) correlates with disease severity and anti–U1-70 autoantibody production. These T cells also express RORγt and produce IL-17A. Furthermore, the U1-70–specific CD4+ T cells that produce IL-17A are detected in a subset of patients with SLE and are significantly increased in patients with mixed connective tissue disease. These studies provide tools for studying antigen-specific CD4+ T cells in lupus, and demonstrate an antigen-specific source of IL-17A in autoimmune disease.

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