Branched and Linear Poly(Ethylene Glycol): Influence of the Polymer Structure on Enzymological, Pharmacokinetic, and Immunological Properties of Protein Conjugates

1997 ◽  
Vol 12 (3) ◽  
pp. 196-207 ◽  
Author(s):  
Francesco M. Veronese ◽  
Paolo Caliceti ◽  
Oddone Schiavon
Keyword(s):  
Ethylene Glycol ◽  
Polymer Structure ◽  
Poly Ethylene Glycol ◽  
Immunological Properties ◽  
Protein Conjugates ◽  
Linear Poly ◽  
Poly Ethylene

scholarly journals Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo

2019 ◽  
Vol 5 (2) ◽  
pp. eaav9322 ◽  
Author(s):  
Dali Wang ◽  
Jiaqi Lin ◽  
Fei Jia ◽  
Xuyu Tan ◽  
Yuyan Wang ◽  
...  
Keyword(s):  
Rna Interference ◽  
Ethylene Glycol ◽  
Target Genes ◽  
Area Under The Curve ◽  
Fold Increase ◽  
Small Interfering Rnas ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene

Nonhepatic delivery of small interfering RNAs (siRNAs) remains a challenge for development of RNA interference–based therapeutics. We report a noncationic vector wherein linear poly(ethylene glycol) (PEG), a polymer generally considered as inert and safe biologically but ineffective as a vector, is transformed into a bottlebrush architecture. This topology provides covalently embedded siRNA with augmented nuclease stability and cellular uptake. Consisting almost entirely of PEG and siRNA, the conjugates exhibit a ~25-fold increase in blood elimination half-life and a ~19-fold increase in the area under the curve compared with unmodified siRNA. The improved pharmacokinetics results in greater tumor uptake and diminished liver capture. Despite the structural simplicity these conjugates efficiently knock down target genes in vivo without apparent toxic and immunogenic reactions. Given the benign biological nature of PEG and its widespread precedence in biopharmaceuticals, we anticipate the brush polymer–based technology to have a significant impact on siRNA therapeutics.

Novel Poly(ethylene glycol) Derivatives for Preparation of Ribosome-Inactivating Protein Conjugates

2002 ◽  
Vol 13 (4) ◽  
pp. 757-765 ◽  
Author(s):  
Silvia Arpicco ◽  
Franco Dosio ◽  
Andrea Bolognesi ◽  
Chiara Lubelli ◽  
Paola Brusa ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Ribosome Inactivating Protein ◽  
Protein Conjugates ◽  
Poly Ethylene ◽  
Ethylene Glycol Derivatives

Enzymatically crosslinked hydrogels based on linear poly(ethylene glycol) polymer: performance and mechanism

2017 ◽  
Vol 8 (45) ◽  
pp. 7017-7024 ◽  
Author(s):  
Kaixuan Ren ◽  
Bin Li ◽  
Qinghua Xu ◽  
Chunsheng Xiao ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Horseradish Peroxidase ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene ◽  
Performance And Mechanism

A horseradish peroxidase-catalyzed hydrogel based on a double-end tyramine conjugated linear poly(ethylene glycol) polymer is developed and clarified.

Complexation of Molecular Iodine by Linear Poly (Ethylene Glycol)

1979 ◽  
Vol 12 (7-8) ◽  
pp. 535-541 ◽  
Author(s):  
S. Hemalatha ◽  
B. Chandani ◽  
D. Balasubramanian
Keyword(s):  
Ethylene Glycol ◽  
Molecular Iodine ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene
Sign in / Sign up

Export Citation Format

Share Document