Hyperbranched fluoropolymer and linear poly(ethylene glycol) based amphiphilic crosslinked networks as efficient antifouling coatings: An insight into the surface compositions, topographies, and morphologies

2004 ◽  
Vol 42 (24) ◽  
pp. 6193-6208 ◽  
Author(s):  
Chakravarthy S. Gudipati ◽  
C. Michael Greenlief ◽  
Jeremiah A. Johnson ◽  
Pornpimol Prayongpan ◽  
Karen L. Wooley
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Antifouling Coatings ◽  
Linear Poly ◽  
Crosslinked Networks ◽  
Poly Ethylene ◽  
Insight Into

scholarly journals Bottlebrush-architectured poly(ethylene glycol) as an efficient vector for RNA interference in vivo

2019 ◽  
Vol 5 (2) ◽  
pp. eaav9322 ◽  
Author(s):  
Dali Wang ◽  
Jiaqi Lin ◽  
Fei Jia ◽  
Xuyu Tan ◽  
Yuyan Wang ◽  
...  
Keyword(s):  
Rna Interference ◽  
Ethylene Glycol ◽  
Target Genes ◽  
Area Under The Curve ◽  
Fold Increase ◽  
Small Interfering Rnas ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene

Nonhepatic delivery of small interfering RNAs (siRNAs) remains a challenge for development of RNA interference–based therapeutics. We report a noncationic vector wherein linear poly(ethylene glycol) (PEG), a polymer generally considered as inert and safe biologically but ineffective as a vector, is transformed into a bottlebrush architecture. This topology provides covalently embedded siRNA with augmented nuclease stability and cellular uptake. Consisting almost entirely of PEG and siRNA, the conjugates exhibit a ~25-fold increase in blood elimination half-life and a ~19-fold increase in the area under the curve compared with unmodified siRNA. The improved pharmacokinetics results in greater tumor uptake and diminished liver capture. Despite the structural simplicity these conjugates efficiently knock down target genes in vivo without apparent toxic and immunogenic reactions. Given the benign biological nature of PEG and its widespread precedence in biopharmaceuticals, we anticipate the brush polymer–based technology to have a significant impact on siRNA therapeutics.

Enzymatically crosslinked hydrogels based on linear poly(ethylene glycol) polymer: performance and mechanism

2017 ◽  
Vol 8 (45) ◽  
pp. 7017-7024 ◽  
Author(s):  
Kaixuan Ren ◽  
Bin Li ◽  
Qinghua Xu ◽  
Chunsheng Xiao ◽  
Chaoliang He ◽  
...  
Keyword(s):  
Horseradish Peroxidase ◽  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene ◽  
Performance And Mechanism

A horseradish peroxidase-catalyzed hydrogel based on a double-end tyramine conjugated linear poly(ethylene glycol) polymer is developed and clarified.

Investigation of the role of hydrophilic chain length in amphiphilic perfluoropolyether/poly(ethylene glycol) networks: towards high-performance antifouling coatings

Biofouling ◽  
2011 ◽  
Vol 27 (10) ◽  
pp. 1139-1150 ◽  
Author(s):  
Yapei Wang ◽  
Louis M. Pitet ◽  
John A. Finlay ◽  
Lenora H. Brewer ◽  
Gemma Cone ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Chain Length ◽  
High Performance ◽  
Poly Ethylene Glycol ◽  
Antifouling Coatings ◽  
Poly Ethylene

Synthesis of catechol and zwitterion-bifunctionalized poly(ethylene glycol) for the construction of antifouling surfaces

2016 ◽  
Vol 7 (2) ◽  
pp. 493-501 ◽  
Author(s):  
Li Qun Xu ◽  
Dicky Pranantyo ◽  
Koon-Gee Neoh ◽  
En-Tang Kang ◽  
Serena Lay-Ming Teo ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Antifouling Coatings ◽  
Poly Ethylene

Versatile antifouling coatings from catechol and zwitterion-bifunctionalized poly(ethylene glycol).

Complexation of Molecular Iodine by Linear Poly (Ethylene Glycol)

1979 ◽  
Vol 12 (7-8) ◽  
pp. 535-541 ◽  
Author(s):  
S. Hemalatha ◽  
B. Chandani ◽  
D. Balasubramanian
Keyword(s):  
Ethylene Glycol ◽  
Molecular Iodine ◽  
Poly Ethylene Glycol ◽  
Linear Poly ◽  
Poly Ethylene
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