Prognostic Value of Intratumoral Collagen Quantification in Canine Oral Melanomas

The majority of the melanocytic neoplasms are considered malignant and highly metastatic. However, a subset of the melanocytic tumors has a more favorable prognosis and the identification of precise prognostic markers for this neoplasm may be useful to guide treatment. The collagen architecture and density have been shown to correlate with tumor progression in human breast cancer and canine mast cell tumors. The purpose of the present study was to investigate the prognostic value of the intratumoral collagen index (ICI) as an indicator of postsurgical survival and its relation with other prognostic markers for canine oral melanomas (OMs). Twenty-two cases were tested for intratumoral collagen density using Masson's trichrome stain and morphometry. No differences were found between dogs regarding survival. The ICI was not correlated with proliferative activity or nuclear atypia. The results presented herein indicate that the quantity of intratumoral collagen in canine OMs is not an efficient indicator of postsurgical survival. Complementary studies about the expression and activity of enzymes that are capable of degrading extracellular matrix (ECM) components are necessary.

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Proteomic Portrait of Human Breast Cancer Progression Identifies Novel Prognostic Markers

Cancer Research ◽

10.1158/0008-5472.can-11-3711 ◽

2012 ◽

Vol 72 (9) ◽

pp. 2428-2439 ◽

Cited By ~ 88

Author(s):

Tamar Geiger ◽

Stephen F. Madden ◽

William M. Gallagher ◽

Juergen Cox ◽

Matthias Mann

Keyword(s):

Breast Cancer ◽

Cancer Progression ◽

Human Breast Cancer ◽

Prognostic Markers ◽

Breast Cancer Progression ◽

Human Breast

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The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer

International Seminars in Surgical Oncology ◽

10.1186/1477-7800-5-23 ◽

2008 ◽

Vol 5 (1) ◽

Cited By ~ 35

Author(s):

Jane Lane ◽

Tracey A Martin ◽

Robert E Mansel ◽

Wen G Jiang

Keyword(s):

Breast Cancer ◽

Human Breast Cancer ◽

Prognostic Value ◽

Guanine Nucleotide Exchange Factors ◽

Guanine Nucleotide ◽

Nucleotide Exchange ◽

Human Breast ◽

Guanine Nucleotide Exchange ◽

Nucleotide Exchange Factors

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In Vitro and In Silico Determination of some N-ferrocenylmethylaniline Derivatives as Anti-Proliferative Agents against MCF-7 Human Breast Cancer Cell Lines

Anti-Cancer Agents in Medicinal Chemistry ◽

10.2174/1871520621666210624141712 ◽

2021 ◽

Vol 21 ◽

Author(s):

Nadjiba Zegheb ◽

Cherifa Boubekri ◽

Touhami Lanez ◽

Elhafnaoui Lanez ◽

Tuba Tüylü Küçükkılınç ◽

...

Keyword(s):

Breast Cancer ◽

Cell Lines ◽

Cancer Cell ◽

Breast Cancer Cell ◽

Proliferative Activity ◽

Human Breast Cancer ◽

Breast Cancer Cell Lines ◽

Human Breast ◽

Ferrocene Derivatives ◽

Mcf 7

Background: Since the binding of estradiol to its receptor promotes breast cancer cell proliferation (in the ER+ tumours), many molecules targeting this protein have been synthesized to counteract the estradiol action. Ferrocene derivatives have proved their efficiency against hormone-dependent breast cancer cells (MCF-7). Objective: In this study, we aimed to find new ferrocene derivatives having pharmacochemistry properties as potential drugs against human breast cancer cells. Methods: A series of 29 N-ferrocenylmethylaniline derivatives A0-A28 were synthesised, and their anti-proliferative activity against both hormone-dependent (MCF-7) and independent (MDA-MB 231) human breast cancer cell lines were performed using the MTT test. Molecular docking and drug-likeness prediction were also performed for the five most active derivatives towards MCF-7. A QSAR model was also developed for the perdition of the anti-proliferative activity against MCF-7 cell lines using molecular descriptors and MLR analysis. Results: All studied derivatives demonstrated better cytotoxicity against MCF-7 compared to the MDA-MB-231 cell lines, and compounds A2, A9, A14, A17, and A27 were the most potent ones; however, but still less active than the standard anti-cancer drug crizotinib. The QSAR study revealed good predictive ability as shown by R2cv = 0.848. Conclusion: In vitro and in silico results indicated that derivatives A2, A9, A14, A17, and A27 possess the highest anti-proliferative activity, t. These results can be used to design more potent N-ferrocenylmethylaniline derivatives as anti-proliferative agents.

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