scholarly journals Long non-coding RNAs as prognostic markers in human breast cancer

Oncotarget ◽  
2016 ◽  
Vol 7 (15) ◽  
pp. 20584-20596 ◽  
Author(s):  
Hairong Liu ◽  
Juan Li ◽  
Pratirodh Koirala ◽  
Xianfeng Ding ◽  
Binghai Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Prognostic Markers ◽  
Human Breast ◽  
Non Coding Rnas

scholarly journals Proteomic Portrait of Human Breast Cancer Progression Identifies Novel Prognostic Markers

2012 ◽  
Vol 72 (9) ◽  
pp. 2428-2439 ◽  
Author(s):  
Tamar Geiger ◽  
Stephen F. Madden ◽  
William M. Gallagher ◽  
Juergen Cox ◽  
Matthias Mann
Keyword(s):  
Breast Cancer ◽  
Cancer Progression ◽  
Human Breast Cancer ◽  
Prognostic Markers ◽  
Breast Cancer Progression ◽  
Human Breast

scholarly journals Primate-specific oestrogen-responsive long non-coding RNAs regulate proliferation and viability of human breast cancer cells

Open Biology ◽  
2016 ◽  
Vol 6 (12) ◽  
pp. 150262 ◽  
Author(s):  
Chin-Yo Lin ◽  
Erica L. Kleinbrink ◽  
Fabien Dachet ◽  
Juan Cai ◽  
Donghong Ju ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Viability ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Oestrogen Receptor ◽  
Breast Cancer Cells ◽  
Signalling Pathways ◽  
Human Breast Cancer Cells ◽  
Human Breast ◽  
Non Coding Rnas

Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class of genes which do not code for proteins. LncRNA genes are approximately as numerous as protein-coding genes in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes in the lncRNA transcriptome of oestrogen receptor positive human breast cancer cells following treatment with oestrogen, and identified 127 oestrogen-responsive lncRNAs. Consistent with the emerging evidence that most human lncRNA genes lack homologues outside of primates, our evolutionary analysis revealed primate-specific lncRNAs downstream of oestrogen signalling. We demonstrate, using multiple functional assays to probe gain- and loss-of-function phenotypes in two oestrogen receptor positive human breast cancer cell lines, that two primate-specific oestrogen-responsive lncRNAs identified in this study (the oestrogen-repressed lncRNA BC041455, which reduces cell viability, and the oestrogen-induced lncRNA CR593775, which increases cell viability) exert previously unrecognized functions in cell proliferation and growth factor signalling pathways. The results suggest that oestrogen-responsive lncRNAs are capable of altering the proliferation and viability of human breast cancer cells. No effects on cellular phenotypes were associated with control transfections. As heretofore unappreciated components of key signalling pathways in cancers, including the MAP kinase pathway, lncRNAs hence represent a novel mechanism of action for oestrogen effects on cellular proliferation and viability phenotypes. This finding warrants further investigation in basic and translational studies of breast and potentially other types of cancers, has broad relevance to lncRNAs in other nuclear hormone receptor pathways, and should facilitate exploiting and targeting these cell viability modulating lncRNAs in post-genomic therapeutics.

scholarly journals Genome-wide DNA methylome analysis reveals novel epigenetically dysregulated non-coding RNAs in human breast cancer

2014 ◽  
Author(s):  
Yongsheng Li ◽  
Yunpeng Zhang ◽  
Shengli Li ◽  
Jianping Lu ◽  
Juan Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Target Genes ◽  
Cpg Islands ◽  
Aberrant Methylation ◽  
Breast Cancers ◽  
Human Breast ◽  
Protein Coding ◽  
Methylome Analysis ◽  
Non Coding Rnas

The development of human breast cancer is driven by changes in the genetic and epigenetic landscape of the cell. Despite growing appreciation of the importance of epigenetics in breast cancers, our knowledge of epigenetic alterations of non-coding RNAs (ncRNAs) in breast cancers remains limited. Here, we explored the epigenetic patterns of ncRNAs in breast cancers via a sequencing-based comparative methylome analysis, mainly focusing on two most popular ncRNA biotypes, long non-coding RNAs (lncRNAs) and miRNAs. Besides global hypomethylation and extensive CpG islands (CGIs) hypermethylation, we observed widely aberrant methylation in the promoters of ncRNAs, which was higher than that of protein-coding genes. Specifically, intergenic ncRNAs were observed to contribute a large slice of the aberrantly methylated ncRNA promoters. Moreover, we summarized five patterns of ncRNA promoter aberrant methylation in the context of genomic CGIs, where aberrant methylation occurred not only on the CGIs, but also flanking regions and CGI sparse promoters. Integration with transcriptional datasets, we found that the ncRNA promoter methylation events were associated with transcriptional changes. Furthermore, a panel of ncRNAs were identified as biomarkers that were able to discriminate between disease phenotypes (AUCs>0.90). Finally, the potential functions for aberrantly methylated ncRNAs were predicted based on similar patterns, adjacency and/or target genes, highlighting that ncRNAs and coding genes coordinately mediated pathways dysregulation in the development and progression of breast cancers. This study presents the aberrant methylation patterns of ncRNAs, which will be a highly valuable resource for investigations at understanding epigenetic regulation of breast cancers.

EMT promoting transcription factors as prognostic markers in human breast cancer

2017 ◽  
Vol 295 (4) ◽  
pp. 817-825 ◽  
Author(s):  
Magdalena Matysiak ◽  
Lucyna Kapka-Skrzypczak ◽  
Barbara Jodłowska-Jędrych ◽  
Marcin Kruszewski
Keyword(s):  
Breast Cancer ◽  
Transcription Factors ◽  
Human Breast Cancer ◽  
Prognostic Markers ◽  
Human Breast

scholarly journals Expression of the Multidrug-Resistance Gene Product in Untreated Human Breast Cancer and its Relationship to Prognostic Markers

1994 ◽  
Vol 33 (7) ◽  
pp. 773-777 ◽  
Author(s):  
Manuel de la Torre ◽  
Rolf Larsson ◽  
Peter Nygren ◽  
Anders Lindgren ◽  
Jonas Bergh
Keyword(s):  
Breast Cancer ◽  
Multidrug Resistance ◽  
Resistance Gene ◽  
Gene Product ◽  
Human Breast Cancer ◽  
Prognostic Markers ◽  
Human Breast ◽  
Multidrug Resistance Gene

scholarly journals Comparison of the metastasis-inducing protein S100A4 (p9ka) with other prognostic markers in human breast cancer

2000 ◽  
Vol 89 (2) ◽  
pp. 198-208 ◽  
Author(s):  
Angela M. Platt-Higgins ◽  
Christine A. Renshaw ◽  
Christopher R. West ◽  
John H.R. Winstanley ◽  
Suzete De Silva Rudland ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Prognostic Markers ◽  
Human Breast

scholarly journals Genome-wide DNA methylome analysis reveals epigenetically dysregulated non-coding RNAs in human breast cancer

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Yongsheng Li ◽  
Yunpeng Zhang ◽  
Shengli Li ◽  
Jianping Lu ◽  
Juan Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Breast Cancer ◽  
Human Breast ◽  
Dna Methylome ◽  
Genome Wide ◽  
Methylome Analysis ◽  
Non Coding Rnas
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